Marine Metabolomics and Microbiomics for Investigations of Secondary Metabolites

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1793

Special Issue Editors


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Guest Editor
UAR 3278 CRIOBE, Université de Perpignan Via Domitia, Perpignan, France
Interests: chemical ecology; specialized metabolites; marine natural products; marine metabolomics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
UAR 3278 CRIOBE, Université de Perpignan Via Domitia, Perpignan, France
Interests: microbiology; ecology; evolution; genomic; metabarcoding; interactions between micro- and macroorganisms

Special Issue Information

Dear Colleagues,                

It is now assumed that marine organisms could be considered as holobionts, consortiums formed by eukaryotic hosts and their associated microorganisms (bacteria, virus, fungi, microalgae, etc.). Host-associated microorganisms (collectively referred to as the microbiome) have sometimes been recognized as producers of secondary bioactive metabolites found in their hosts. From an ecological point of view, little is known concerning the role of holobiont metabolites, and particularly if they contribute to the defense against harmful microbes or the growth or colonization of helpful ones. Thus, understanding interactions between marine organisms, microbiome, and their environment appears as an emerging way of exploring their complex functioning, their ecological roles within ecosystems, and their adaptation to face environmental changes. This global approach can be sustained by the use of “omics” technologies such as metabolomics and microbiomics, and the new strategies developed to highlight correlations between both types of datasets within holobionts.

This Special Issue invites articles from both metabolomics and microbiomics studies performed on marine organisms. We particularly welcome articles that combine these two approaches for the understanding of interactions between marine organisms and their environment, and the discovery of new bioactive endogenous or exogenous compounds produced at the holobiont level.

Dr. Nathalie Tapissier
Dr. Camille Clerissi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome diversity
  • host–microbiome interactions
  • metabolomics
  • multi-omics
  • metabarcoding
  • marine organisms
  • secondary metabolites
  • integrative approach
  • chemical ecology

Published Papers (1 paper)

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Research

21 pages, 4686 KiB  
Article
Metabolic Profiling, Antiviral Activity and the Microbiome of Some Mauritian Soft Corals
by Deeya Jahajeeah, Mala Ranghoo-Sanmukhiya and Georgia Schäfer
Mar. Drugs 2023, 21(11), 574; https://doi.org/10.3390/md21110574 - 31 Oct 2023
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Abstract
Soft corals, recognized as sessile marine invertebrates, rely mainly on chemical, rather than physical defense, by secreting intricate secondary metabolites with plausible pharmaceutical implication. Their ecological niche encompasses a diverse community of symbiotic microorganisms which potentially contribute to the biosynthesis of these bioactive [...] Read more.
Soft corals, recognized as sessile marine invertebrates, rely mainly on chemical, rather than physical defense, by secreting intricate secondary metabolites with plausible pharmaceutical implication. Their ecological niche encompasses a diverse community of symbiotic microorganisms which potentially contribute to the biosynthesis of these bioactive metabolites. The emergence of new viruses and heightened viral resistance underscores the urgency to explore novel pharmacological reservoirs. Thus, marine organisms, notably soft corals and their symbionts, have drawn substantial attention. In this study, the chemical composition of four Mauritian soft corals: Sinularia polydactya, Cespitularia simplex, Lobophytum patulum, and Lobophytum crassum was investigated using LC–MS techniques. Concurrently, Illumina 16S metagenomic sequencing was used to identify the associated bacterial communities in the named soft corals. The presence of unique biologically important compounds and vast microbial communities found therein was further followed up to assess their antiviral effects against SARS-CoV-2 and HPV pseudovirus infection. Strikingly, among the studied soft corals, L. patulum displayed an expansive repertoire of unique metabolites alongside a heightened bacterial consort. Moreover, L. patulum extracts exerted some promising antiviral activity against SARS-CoV-2 and HPV pseudovirus infection, and our findings suggest that L. patulum may have the potential to serve as a therapeutic agent in the prevention of infectious diseases, thereby warranting further investigation. Full article
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