Structure–Activity Relationship of Marine Bioactive Compounds
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (20 December 2020) | Viewed by 14892
Special Issue Editor
Interests: marine natural products; isolation and structural elucidation; organic synthesis; biological activity; medicinal chemistry; bacterial iron uptake; siderophores
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Marine organisms constitute a rich source of biologically active and chemically diverse natural products and serve as an invaluable resource in the ongoing search for novel bioactive compounds. A rational study provides information on the design of compounds or the understanding of the mechanism, or clarifies the discovery, design or optimization of new potent compounds as biological agents. The relationship between chemical structure and biological activity is related to the specific action of a bioactive marine natural product. For that reason, the determination of structure–activity relationships of these bioactive molecules is a crucial step in their development as a new drug, agrochemical, cosmetic or other application based on their activity. Studies on the influence on the bioactivity of the size, shape, and degree of ionization of bioactive Marine Natural Products is a topic of growing interest nowadays due to its potential applications with increased potency, greater selectivity, higher stability, and lower toxicity. Current research also focuses on the molecular modifications of reported series that lead to a significantly improved understanding of their structure–activity relationships. As Guest Editor of this Special Issue of Marine Drugs, I invite you to provide recent advances in all the aspects dealing with the structure–activity relationship of marine bioactive compounds.
Prof. Dr. Carlos Jimenez
Guest Editor
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Keywords
- Marine natural products
- Biological activity
- Drug discovery
- Structure–activity relationships
- Synthetic and natural analogs
- Elucidation of pharmacophore
- Biological action mechanism
- Target protein on the bioactive substances
- Quantitative structure–activity relationships (QSAR)
- ADMET studies
- Molecular modeling
- Combinatorial chemistry
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