Marine Siderophores: Structures, Biological Roles and Applications
A special issue of Marine Drugs (ISSN 1660-3397).
Deadline for manuscript submissions: closed (15 November 2021) | Viewed by 4432
Special Issue Editor
Interests: marine natural products; isolation and structural elucidation; organic synthesis; biological activity; medicinal chemistry; bacterial iron uptake; siderophores
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Iron is a crucial nutrient in virtually all living organisms. Due to the very low bioavailability of free ion, one of the major strategies used by bacteria and fungi, and also plants, entailed the use of siderophores which are low molecular weight organic compounds that have extremely high affinity for ferric iron. They are excreted to form a ferric-siderophore complex which is then internalized by the appropriate transport mechanism. While the terrestrial siderophores have been extensively study, the structural features of most marine siderophores have not yet been determined. For pathogenic microorganisms, they are key virulence factors to enhance the infection disease. Iron uptake mechanism mediated by siderophores provides an ideal target for antimicrobial and therapeutic potential applications: siderophore-mediated drug delivery (Trojan horse strategy), iron overload, vaccines, etc. Additionally to medical applications, they can be used effectively for numerous processes such as bioremediation, biofertilization, metals detection (siderosensing), molecular imagining, etc. Current research also focuses on the understanding their ecological roles and on the development of their chemical synthesis to promote new biotechnological applications. As Guest Editor of this Special Issue of Marine Drugs, I invite you to provide recent advances in all the aspects dealing with Marine Siderophores.
Prof. Dr. Carlos Jiménez
Guest Editor
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Keywords
- Siderophores;
- Iron uptake mechanisms;
- Synthesis of natural siderophores and their analogs;
- Siderophore–drug conjugates;
- Siderophore-mediated drug delivery;
- Biotechnological applications
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