Green Extraction of High-Value Compounds in Marine Algae

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 619

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Centro de Investigación Traslacional San Alberto Magno (CITSAM), Universidad Católica de Valencia, “San Vicente Mártir”, C/ Quevedo 2, 46001 Valencia, Spain
Interests: biotechnology

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CIIMAR/CIMAR, Interdisciplinary Centre of Marine and Environmental Research, Novo Edifício do Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de Matos, S/N, 4450-208 Matosinhos, Portugal
Interests: antioxidants; free radicals; inflammation; iNOS; LOX; phlorotannins; carotenoids; phenols; seaweeds; HPLC
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Dear Colleagues,

Marine algae, both macro- and micro-, are essential sources of high-value compounds due to their versatility and sustainability as CO2 and nutrient scavengers.

Secondary metabolites from algae have diverse applications, such as emulsifiers, antioxidants, and anti-aging agents, driving a high demand for their efficient extraction in multiple industries. Hence, research in this field is prolific. However, the current demand for products in these industries also requires sustainable extraction methods that maximize the potential of algal biomass while ensuring high yields and purity of the targeted compounds. Innovative extraction methodologies and alternative solvents must be employed to develop environmentally friendly processes that reduce energy inputs and extraction times compared to conventional methods.

This Special Issue invites papers focused on the extraction of high-value compounds from macro- and microalgae, particularly those highlighting sustainability through green solvents or green extraction methodologies.

Dr. Padrón-Sanz Carolina
Dr. Graciliana Lopes
Guest Editors

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Keywords

  • green extraction methods
  • green solvents
  • biorefinery
  • ultrasonic assisted extraction
  • microwave assisted extraction
  • supercritical fluid extraction
  • subcritical water extraction
  • pressurized liquid extraction
  • pulsed electric field
  • ionic liquids

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Published Papers (1 paper)

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Research

12 pages, 1339 KiB  
Article
Optimized Extraction of Sargahydroquinoic Acid, Major Bioactive Substance, from Sargassum yezoense Using Response Surface Methodology
by Suhyeon Baek, Ji-Eun Bae, Yu Miao, Gahyeon Kim, Bomi Ryu, Byung-Hoo Lee and Sanggil Lee
Mar. Drugs 2024, 22(12), 543; https://doi.org/10.3390/md22120543 - 2 Dec 2024
Viewed by 437
Abstract
Sargahydroquinoic acid (SHQA), a bioactive compound found in certain Sargassum species, exhibits significant health benefits. This study optimized the extraction of SHQA from Sargassum yezoense using response surface methodology (RSM) and evaluated its antioxidant effects through in vitro and in vivo assays. A [...] Read more.
Sargahydroquinoic acid (SHQA), a bioactive compound found in certain Sargassum species, exhibits significant health benefits. This study optimized the extraction of SHQA from Sargassum yezoense using response surface methodology (RSM) and evaluated its antioxidant effects through in vitro and in vivo assays. A Box–Behnken design (BBD) was effectively employed to investigate the effects of incubation temperature, time, and ethanol concentration on SHQA yield, achieving a high coefficient of determination (R2 = 0.961). Analysis of variance (ANOVA) validated the model’s reliability (F = 13.86, p = 0.005) and highlighted ethanol concentration as a highly significant factor (p < 0.001). Optimal extraction conditions were identified as 52.8 °C, 8.3 h, and 74.1% ethanol. The SHQA-maximized extract (SME) contained 67.8 ± 0.6 mg SHQA/g and 25.00 ± 1.01 mg phloroglucinol equivalent/g. SME exhibited antioxidant capacity of 26.45 ± 0.66 mg and 28.74 ± 2.30 mg vitamin C equivalent/g in ABTS and DPPH assays, respectively, and 0.29 ± 0.02 mM FeSO4 equivalent/g in the FRAP assay. Additionally, SME at 50 µg/mL and SHQA at 1 µg/mL inhibited reactive oxygen species (ROS) generation in an H2O2-induced zebrafish model. This study presents the first optimization of SHQA extraction using RSM and demonstrates SHQA’s ROS inhibition in a zebrafish model. Full article
(This article belongs to the Special Issue Green Extraction of High-Value Compounds in Marine Algae)
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