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Marine Waste and By-Products as a Source of High Value Bioproducts

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: 15 August 2026 | Viewed by 1714

Editors


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Guest Editor
Centre for Sustainable Bioproducts, Faculty of Science, Engineering and Built Environment, Deakin University, 75 Pigdons Road, Geelong, VIC 3216, Australia
Interests: marine biotechnology; functional foods; nutraceutical development; lipid chemistry; omega-3 and marine oils; sustainable bioproducts; bioactive extraction and characterization; marine biorefinery; food innovation and industrial translation
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Guest Editor
School of Agriculture, Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC 3010, Australia
Interests: food chemistry; functional foods; plant bioactives; food waste valorization; LC-MS/MS profiling; nutrition and health; sustainable food processing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,                

Marine industries generate large volumes of wastes and by-products during processing, including shells, skins, viscera, seaweed residues, and microalgal biomass. These materials are increasingly recognized as valuable sources of bioactive compounds such as peptides, polyphenols, polysaccharides, lipids, pigments, and enzymes with significant potential for applications in pharmaceuticals, nutraceuticals, functional foods, and sustainable biomaterials.

Despite their potential, marine by-products remain underutilized globally. Their valorization offers substantial environmental and economic benefits while supporting circular bioeconomy and sustainable marine resource management.

This Special Issue aims to present recent advances in the recovery, characterization, and application of high-value compounds derived from marine wastes and by-products. Emphasis will be placed on innovative extraction technologies, bioactivity evaluation, sustainability considerations, and industrial translation.

Topics of interest include, but are not limited to, the following:

  • Extraction and purification of marine bioactive compounds
  • Identification and compositional analysis of marine wastes and by-products
  • Marine peptides, polysaccharides, lipids, pigments, and enzymes
  • Nutraceutical and pharmaceutical applications
  • Functional foods and food ingredient development
  • Green extraction and sustainable processing technologies
  • Fermentation and marine biotechnology approaches
  • Bioactivity, bioavailability, and safety evaluation
  • Circular bioeconomy and marine biorefinery systems
  • Industrial scalability and commercialization pathways

We welcome original research articles, reviews, and communications addressing emerging developments in marine waste valorization and high-value compound development.

Prof. Dr. Colin Barrow
Dr. Hafiz Suleria
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • marine wastes
  • marine by-products
  • bioactive compounds
  • marine peptides
  • polysaccharides
  • marine lipids
  • pigments
  • marine enzymes
  • nutraceuticals
  • functional foods
  • marine biotechnology
  • green extraction technologies
  • marine biorefinery
  • circular bioeconomy
  • metabolomics
  • bioavailability
  • food processing
  • sustainability
  • industrial applications

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Published Papers (2 papers)

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Research

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22 pages, 3669 KB  
Article
In Vitro Gastrointestinal Digestion of Calanus finmarchicus Products: Amino Acid Composition, Degree of Hydrolysis, Antioxidant Capacity, and Antidiabetic Activity
by Ying Wang, Karl-Erik Eilertsen, Edel Oddny Elvevoll, Chun Li and Ida-Johanne Jensen
Mar. Drugs 2026, 24(7), 240; https://doi.org/10.3390/md24070240 - 7 Jul 2026
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Abstract
Marine rest raw materials are often undervalued or wasted despite their nutrient and bioactive composition. Calanus finmarchicus, harvested primarily for its omega-3-rich oil, yields a side-stream protein hydrolysate, C. finmarchicus hydrolysate (CFH), during commercial enzyme-assisted extraction. Although currently used as a feed [...] Read more.
Marine rest raw materials are often undervalued or wasted despite their nutrient and bioactive composition. Calanus finmarchicus, harvested primarily for its omega-3-rich oil, yields a side-stream protein hydrolysate, C. finmarchicus hydrolysate (CFH), during commercial enzyme-assisted extraction. Although currently used as a feed ingredient, CFH contains low-molecular-weight peptides and free amino acids with potential for human health applications. This study evaluated the gastrointestinal stability of CFH and the impact of digestion on bioactivity using a static in vitro gastrointestinal digestion model. Fresh-frozen and freeze-dried C. finmarchicus were included to provide comparative data. Antioxidant capacity was measured by ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays, and antidiabetic activity by dipeptidyl peptidase-IV (DPP-IV) and protein tyrosine phosphatase 1B (PTP1B) inhibition assays. The hydrolysate maintained its antioxidant capacity throughout digestion (at 165 min: FRAP: 27.5 ± 0.6 µmol TE/g dry weight (DW); ORAC: 411 ± 37 µmol TE/g DW). Digestion increased its DPP-IV inhibitory activity, with the inhibitory concentration (IC50) decreased from 3.73 to 1.96 mg/mL (p ≥ 0.05). PTP1B inhibitors were nonselective and detected only at 0 and 30 min. These findings support our hypothesis that CFH may serve as a nutraceutical for humans and provide a rationale for subsequent in vivo studies. However, further identification of bioactive components and in vivo validation are warranted. Full article
(This article belongs to the Special Issue Marine Waste and By-Products as a Source of High Value Bioproducts)
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Review

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47 pages, 3196 KB  
Review
Red Seaweed-Derived Phycobiliproteins: Marine Bioactive Colorants with Functional Health Properties
by Yiming Sun, Yi Zhou, Minyao Wang, Faezeh Ebrahimi, Muhammad Sajid Arshad, Colin J. Barrow and Hafiz Ansar Rasul Suleria
Mar. Drugs 2026, 24(7), 246; https://doi.org/10.3390/md24070246 - 15 Jul 2026
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Abstract
Color is a critical sensory attribute of foods that strongly influences consumer perception, acceptance, and purchasing decisions. As health-oriented consumption increases, natural pigments are progressively replacing synthetic colorants. Red algal phycobiliproteins (PBPs) have gained attention in related industries for their vivid water-soluble colors [...] Read more.
Color is a critical sensory attribute of foods that strongly influences consumer perception, acceptance, and purchasing decisions. As health-oriented consumption increases, natural pigments are progressively replacing synthetic colorants. Red algal phycobiliproteins (PBPs) have gained attention in related industries for their vivid water-soluble colors and potential health-promoting properties. Phycoerythrin (PE), phycocyanin (PC), and allophycocyanin (APC) are key pigment proteins responsible for their characteristic coloration. However, variations in algal species, season, and cultivation environments make PBP composition, yield, and quality difficult to standardize. This review summarizes red algal PBPs, covering algal sources, extraction and purification, physicochemical properties, biological functions, regulatory frameworks, and future directions. Major red seaweed sources, PBP types, and extraction strategies are compared, with cyanobacterial PBP studies incorporated where direct red algal evidence is limited. Evidence suggests that red algal PBPs are promising for clean-label, water-based, and mildly processed foods, including beverages, dairy products, confectionery, and meat alternatives, but their application is constrained by sensitivity to heat, light, oxygen, and pH. Beyond coloration, PBPs exhibit antioxidant, anti-inflammatory, anticancer, antibacterial, and metabolic health-promoting activities. Overall, red algal PBPs have considerable potential as dual-function ingredients, although commercialization requires advances in raw material standardization, stability-enhancement strategies, process optimization, clinical validation, and regulatory harmonization. Full article
(This article belongs to the Special Issue Marine Waste and By-Products as a Source of High Value Bioproducts)
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