Antioxidant and Anticancer Activities of Compounds Isolated from Seagrasses and Seaweeds

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 970

Special Issue Editors


E-Mail Website
Guest Editor
Department of Botany, School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: ecophysiology; ecotoxicology and ecology of seagrasses and seaweeds; antioxidant and anticancer activity of seagrasses; seaweeds; marine macrophyte; polyphenols and other natural products

E-Mail Website
Guest Editor
Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece
Interests: antioxidant activity of plant extracts; plant polyphenols and other natural products; physiological adaptive mechanisms of human organism to oxidative stress conditions; chemopreventive (anticarcinogenic) activity of plant extracts, plant polyphenols and other natural products; anti-angiogenic activity of chemical compounds (natural or synthetic)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Since 70% of the earth's surface is covered by seas and oceans, marine organisms are an important source of new bioactive compounds promoting human health. Marine macrophytes, including seagrasses (also called marine angiosperms) and marine macroalgae (also called seaweeds), have various uses for humans, such as food, medicine and biofuels, while their compounds exhibit different bioactivities. In addition, marine macrophytes contain a variety of cellular components such as proteins, cellulose, polysaccharides, minerals, and phenolic compounds, which exhibit beneficial properties for human health. Numerous studies have demonstrated the association between oxidative stress and cancer in humans. Thus, the uptake of antioxidants through diet or as food supplements has been suggested for cancer prevention. Interestingly, several compounds isolated from seagrasses and seaweeds have been shown to possess antioxidant and anticancer activities. Although seagrasses and seaweeds have attracted great attention because of their bioactive properties for human health, they are considered as an underexploited resource.

The present Special Issue aims to collect the latest research findings on the isolation of antioxidant and/or anticancer compounds from seagrasses and seaweeds. The compounds could be either individual chemical substances or chemical mixtures. The bioactive compounds may be polyphenols, polysaccharides and peptides, but they could also belong to other chemical categories. Moreover, contributions to this Special Issue could include both in vitro and in vivo studies relating to different aspects of antioxidant activity of compounds from seagrasses and seaweeds, such as structure–activity relationships, regulation of endogenous antioxidant responses (e.g., Nrf2 pathway) and their role in signaling, metabolism, cell cycle, gene regulation, cellular stress, and prevention of diseases. In addition, the investigation of the anticancer properties of compounds from seagrasses and seaweeds could include studies on the inhibition of cancer cell growth and the molecular mechanisms accounting for this activity (e.g., induction of apoptosis and autophagy, cell cycle arrest, inhibition of topoisomerase and angiogenesis). Apart from research studies, review articles are also welcome.

We look forward to receiving your contributions. 

Dr. Paraskevi Malea
Dr. Dimitrios Stagos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • seagrasses
  • seaweeds
  • marine angiosperm
  • marine macroalgae
  • antioxidants
  • anticancer
  • chemoprevention
  • polyphenols
  • bioactive compounds

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

26 pages, 1073 KiB  
Article
Exploring Bioactive Components and Assessing Antioxidant and Antibacterial Activities in Five Seaweed Extracts from the Northeastern Coast of Algeria
by Nawal Bouzenad, Nesrine Ammouchi, Nadjla Chaib, Mohammed Messaoudi, Walid Bousabaa, Chawki Bensouici, Barbara Sawicka, Maria Atanassova, Sheikh F. Ahmad and Wafa Zahnit
Mar. Drugs 2024, 22(6), 273; https://doi.org/10.3390/md22060273 - 12 Jun 2024
Viewed by 259
Abstract
The main goal of this study was to assess the bioactive and polysaccharide compositions, along with the antioxidant and antibacterial potentials, of five seaweeds collected from the northeastern coast of Algeria. Through Fourier transform infrared spectroscopy analysis and X-ray fluorescence spectroscopy, the study [...] Read more.
The main goal of this study was to assess the bioactive and polysaccharide compositions, along with the antioxidant and antibacterial potentials, of five seaweeds collected from the northeastern coast of Algeria. Through Fourier transform infrared spectroscopy analysis and X-ray fluorescence spectroscopy, the study investigated the elemental composition of these seaweeds and their chemical structure. In addition, this study compared and identified the biochemical makeup of the collected seaweed by using cutting-edge methods like tandem mass spectrometry and ultra-high-performance liquid chromatography, and it searched for new sources of nutritionally valuable compounds. According to the study’s findings, Sargassum muticum contains the highest levels of extractable bioactive compounds, showing a phenolic compound content of 235.67 ± 1.13 µg GAE·mg⁻1 and a total sugar content of 46.43 ± 0.12% DW. Both S. muticum and Dictyota dichotoma have high concentrations of good polyphenols, such as vanillin and chrysin. Another characteristic that sets brown algae apart is their composition. It showed that Cladophora laetevirens has an extracted bioactive compound content of 12.07% and a high capacity to scavenge ABTS+ radicals with a value of 78.65 ± 0.96 µg·mL−1, indicating high antioxidant activity. In terms of antibacterial activity, S. muticum seaweed showed excellent growth inhibition. In conclusion, all five species of seaweed under investigation exhibited unique strengths, highlighting the variety of advantageous characteristics of these seaweeds, especially S. muticum. Full article
11 pages, 2106 KiB  
Article
Fucoidan from Lessonia trabeculata Induces Apoptosis through Caspase Dependent and Caspase-Independent Activation in 4T1 Breast Adenocarcinoma In Vitro
by Raisa Teresa Cruz Riquelme, Erasmo Honorio Colona-Vallejos, Libertad Alzamora-Gonzales and Rosa María Condori Macuri
Mar. Drugs 2024, 22(6), 251; https://doi.org/10.3390/md22060251 - 29 May 2024
Viewed by 470
Abstract
Experiments conducted on triple-negative breast cancer have shown that fucoidan from Lessonia trabeculata (FLt) exhibits cytotoxic and antitumor properties. However, further research is necessary to gain a complete understanding of its bioactivity and level of cytotoxicity. The cytotoxic effect of FLt was determined [...] Read more.
Experiments conducted on triple-negative breast cancer have shown that fucoidan from Lessonia trabeculata (FLt) exhibits cytotoxic and antitumor properties. However, further research is necessary to gain a complete understanding of its bioactivity and level of cytotoxicity. The cytotoxic effect of FLt was determined by the 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Apoptosis was analyzed using annexin V and caspase 3/7 staining kit and DNA fragmentation. In addition, transcriptional expression of antiapoptotic (Bcl-2 and XIAP) and proapoptotic (caspase 8, caspase 9, and AIF) genes were analyzed in TNBC 4T1 cells. After 72 h of culture, the IC50 for FLt was 561 μg/mL, while doxorubicin (Dox) had an IC50 of 0.04 μg/mL. In addition, assays for FLt + Dox were performed. Annexin V and caspase 3/7 revealed that FLt induces early and late-stage apoptosis. DNA fragmentation results support necrotic death of 4T1 cells. Similarly, transcripts that prevent cell death were decreased, while transcripts that promote cell death were increased. This study showed that FLt induces apoptosis by both caspase-dependent and caspase-independent mechanisms. These findings suggest that FLt may have potential applications in breast cancer treatment. Further research will provide more information to elucidate the mechanism of action of FLt. Full article
Show Figures

Graphical abstract

Back to TopTop