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Magnetochemistry
Special Issues
Magnetic Nano- and Microparticles in Biotechnology
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Magnetic Nano- and Microparticles in Biotechnology

A special issue of Magnetochemistry (ISSN 2312-7481). This special issue belongs to the section "Magnetic Nanospecies".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 3946

Special Issue Editors

Dr. Ângela Leão Andrade

E-Mail Website
Guest Editor
Departamento de Química, Instituto de Ciências Exatas e Biológicas (ICEB), Universidade Federal de Ouro Preto (UFOP), Ouro Preto 35400-000, MG, Brazil
Interests: magnetic nanoparticles; biomaterials and biocompatible materials
Dr. Rosangela Maria Ferreira da Costa e Silva

E-Mail Website
Guest Editor
Instituto Federal de Educação, Ciência e Tecnologia de Mato Grosso do Sul, Três Lagoas 79641-162, Mato Grosso do Sul, Brazil
Interests: liposomes; magnetoliposomes; bioactive glass; solid oxid fuel cell; magnetite; Equisetum

Special Issue Information

Dear Colleagues,

This Special Issue of Magnetochemistry, entitled "Magnetic Nano- and Microparticles in Biotechnology", aims to explore recent advances in the development and application of magnetic nanoparticles and microparticles in biotechnology, including drug delivery, biomolecular separation and purification, magnetic imaging and therapy.

Due to the growing importance of these materials in biomedical and environmental applications, this Special Issue seeks to compile innovative and high-impact contributions in the field. Experimental and theoretical studies, comprehensive reviews, and original research articles are welcome.

The submission deadline is 30 December 2025. The first authors invited may receive a discount on the publication fees as part of the invitation program.

For further information and more details regarding manuscript submission, please visit the Magnetochemistry website. We look forward to receiving your contributions!

Best regards,

Dr. Ângela Leão Andrade
Dr. Rosangela Maria Ferreira da Costa e Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Magnetochemistry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • microparticles biotechnology
  • including drug delivery
  • biomolecular separation and purification
  • magnetic imaging and therapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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24 pages, 3648 KB  
Article
Ferrofluids Based on Anionic Polysaccharide-Coated Magnetic Nanoparticles for Targeted Magnetocatalytic-Driven Multimodal Anticancer Therapy
by Liliane A. S. Angelo, Alexandra A. P. Mansur, Sandhra M. Carvalho, Klaus Krambrock, Isadora C. Carvalho and Herman S. Mansur
Magnetochemistry 2026, 12(3), 31; https://doi.org/10.3390/magnetochemistry12030031 - 3 Mar 2026
Viewed by 787
Abstract
Regrettably, glioblastoma multiforme (GBM) remains the deadliest form of brain cancer, with a very unfavorable prognosis for life expectancy for the patient. We report, for the first time, the green colloidal synthesis of cobalt-doped magnetic iron oxide nanoparticles (Co-MNPs) as aqueous ferrofluids, using [...] Read more.
Regrettably, glioblastoma multiforme (GBM) remains the deadliest form of brain cancer, with a very unfavorable prognosis for life expectancy for the patient. We report, for the first time, the green colloidal synthesis of cobalt-doped magnetic iron oxide nanoparticles (Co-MNPs) as aqueous ferrofluids, using two anionic polysaccharide biopolymers, hyaluronic acid (HA) and carboxymethyl cellulose (CMC), as surfactants. These ferrofluids based on magnetite nanoparticles (HA@Co-MNP and CMC@Co-MNP) demonstrated superparamagnetic properties and magnetic-to-thermal conversion upon exposure to an alternating magnetic field (AMF), with the extent of conversion dependent on surfactant type. In addition, the ferrophase acted as a nanozyme, mimicking peroxidase-like activity in response to hydrogen peroxide, which is present at higher levels in tumor cells. The coupling of magnetic-heat capabilities with biocatalytic behavior enhances glioblastoma cell elimination and suppresses 3D neurospheroid growth. The results also showed that active targeting based on the HA biopolymer shell, due to its affinity for CD44 membrane receptors overexpressed in GBM, outperformed CMC-coated ferrofluid analogs. These magnetocatalytic-responsive nanoplatforms offer a broad avenue for the diagnosis and therapy of numerous cancers, potentially improving patients’ quality of life and prognoses. Full article
(This article belongs to the Special Issue Magnetic Nano- and Microparticles in Biotechnology)
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19 pages, 2848 KB  
Article
Development of a Cost-Effective Magnetic Microparticle Protocol for DNA Purification in Molecular Diagnosis of Gynecological Infections
by Carolina Otonelo, Carla Layana, Elisa de Sousa, Luciana Juncal, Melina D. Ibarra, Constanza Toledo, Alejo Melamed, Karen L. Salcedo Rodríguez, Patricia L. Schilardi, Lucia Poleri, Carlos Golijow, Sheila Ons, Pedro Mendoza Zélis and Claudia Rodríguez Torres
Magnetochemistry 2026, 12(2), 16; https://doi.org/10.3390/magnetochemistry12020016 - 27 Jan 2026
Viewed by 1098
Abstract
In this work, we evaluate the efficiency of a DNA purification protocol from gynecological samples using locally synthesized Fe3O4@SiO2 magnetic microparticles and a low-cost, guanidinium thiocyanate (GITC)-free lysis buffer. The microparticles were characterized by SEM, EDS, FTIR, and [...] Read more.
In this work, we evaluate the efficiency of a DNA purification protocol from gynecological samples using locally synthesized Fe3O4@SiO2 magnetic microparticles and a low-cost, guanidinium thiocyanate (GITC)-free lysis buffer. The microparticles were characterized by SEM, EDS, FTIR, and magnetic measurements, confirming the formation of compact silica-coated aggregates with suitable magnetic responsiveness for rapid and complete capture. Using this material in combination with a simple, GITC-free lysis buffer, we achieved DNA extraction yields comparable to those obtained with standard methods based on chaotropic salts. The purified DNA showed high compatibility with molecular assays for the detection of Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, and human papilloma virus. Clinical validation demonstrated excellent diagnostic performance, with only a few discrepancies observed in samples near the detection threshold of qPCR, a limitation shared with commercial kits. Overall, the method represents a low-cost, safe, and sustainable alternative for routine clinical and epidemiological applications, compared to methods based on chaotropic salt buffers. Furthermore, it reduces reliance on imported commercial consumables and minimizes the handling of hazardous reagents. Full article
(This article belongs to the Special Issue Magnetic Nano- and Microparticles in Biotechnology)
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Review

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34 pages, 2311 KB  
Review
Iron Oxide Nanoparticles Enabled Ultrasound-Guided Theranostic Systems
by Thiago Tiburcio Vicente, Prabu Periyathambi, Ariane Franson Sanches, Marina Yuki Azevedo Nakakubo, Nicholas Zufelato, Karina Bezerra Salomão, María Sol Brassesco, Theo Zeferino Pavan, Koiti Araki and Antônio A. O. Carneiro
Magnetochemistry 2026, 12(2), 21; https://doi.org/10.3390/magnetochemistry12020021 - 3 Feb 2026
Viewed by 1489
Abstract
The tumor microenvironment, characterized by higher acidity, hypoxia, and dense cellular structures, plays a pivotal role in cancer progression, therapeutic resistance, and treatment response. Nanoparticle-based contrast agents enable the precise delineation of solid regions within heterogeneous tumors through advanced molecular imaging techniques. Since [...] Read more.
The tumor microenvironment, characterized by higher acidity, hypoxia, and dense cellular structures, plays a pivotal role in cancer progression, therapeutic resistance, and treatment response. Nanoparticle-based contrast agents enable the precise delineation of solid regions within heterogeneous tumors through advanced molecular imaging techniques. Since 1956, ultrasound (US) medical imaging has provided essential anatomical and functional insights about internal organs. More recently, magnetomotive ultrasound (MMUS) has emerged as a promising imaging modality, using a modulated magnetic field to exert force on superparamagnetic iron oxide nanoparticles (SPIONs), inducing motion in the surrounding tissues through mechanical coupling. In parallel, magnetic hyperthermia (MH), which employs localized heating by alternating magnetic fields, has demonstrated significant potential in selectively destroying cancer cells while sparing healthy tissues. This review summarizes the current state of IONP-based contrast agents, with particular emphasis on their use in MH for cancer treatment, as well as their potential in multimodal imaging, including MMUS, and photoacoustic (PA) imaging. The advantages and limitations of IONPs in tumor detection and characterization are discussed, examining the development of surface-functionalized MNPs, and analyzing how material properties and environmental factors affect their diagnostic and therapeutical performance. Finally, strategies for combining MMUS and PA modalities for pre-clinical cancer imaging are proposed. Full article
(This article belongs to the Special Issue Magnetic Nano- and Microparticles in Biotechnology)
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