Special Issues

Life publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Knee Biomechanics—2nd Edition
edited by Jason Shearn
submission deadline 22 Jun 2026 | Viewed by 48 | Submission Open
Keywords: knee; tendon; ligament; injury; repair; healing; biomechanics; advanced techniques
(This special issue belongs to the Section Physiology and Pathology)
Reconstruction of Bone Defects submission deadline 23 Jun 2026 | 5 articles | Viewed by 7668 | Submission Open
Keywords: bone and fracture biomechanics; bone healing; critical size bone defects; fracture non-union; inflammation; joint arthroplasty and fracture osteosynthesis; implant designs; materials proprieties; patient selection; primary and revision settings
(This special issue belongs to the Section Medical Research)
Recent Advances in Vascular Biology and Chronic Kidney Disease (CKD)
edited by
submission deadline 26 Jun 2026 | 1 articles | Viewed by 5598 | Submission Open
Keywords: chronic kidney disease; vascular dysfunction; endothelial cells
(This special issue belongs to the Section Medical Research)
Feature Papers in Medical Research: 4th Edition
edited by
submission deadline 26 Jun 2026 | Viewed by 267 | Submission Open
Keywords: dermatological research; cancer research; cardiovascular research; general medicine; gastroenterological research; hematological research; immunological research; infectious diseases research; metabolism and endocrinology; nervous system research; nursing; pediatrics; pulmonary research; psychiatric research; rehabilitation; renal and urinary research; reproductive research and women's health; rheumatological research; skeletal and muscular research; vision research
(This special issue belongs to the Section Medical Research)
Innovations in Thoracic Medicine: Advancements and Challenges—2nd Edition
edited by Paolo Scanagatta
submission deadline 26 Jun 2026 | Viewed by 42 | Submission Open
Keywords: thoracic medicine; lung cancer; artificial intelligence (AI); minimally invasive intervention; thoracic anesthesia; clinical innovation; technological advances
(This special issue belongs to the Section Medical Research)
Advanced Technologies and Clinical Practice of Cancer Radiotherapy
edited by
submission deadline 26 Jun 2026 | Viewed by 30 | Submission Open
Keywords: proton therapy; BNCT; in vivo dose verification in radiotherapy; accelerators for radiation therapy; simulation of radiotherapies
(This special issue belongs to the Section Radiobiology and Nuclear Medicine)
Application of Mass Spectrometry-Based Multi-Omics in Biomedical Research submission deadline 26 Jun 2026 | Viewed by 26 | Submission Open
Keywords: mass spectrometry; multi-omics; proteomics; metabolomics; lipidomics; mass spectrometry imaging (MSI); biomarker discovery; translational research
(This special issue belongs to the Section Medical Research)
Recent Advances in Physiotherapy for Musculoskeletal submission deadline 30 Jun 2026 | 6 articles | Viewed by 12944 | Submission Open
Keywords: musculoskeletal rehabilitation; emerging technologies; virtual reality; artificial intelligence; inflammatory genetics; physiotherapy; sports medicine; functional recovery
(This special issue belongs to the Section Physiology and Pathology)
The Emerging Role of Microbiota in Health and Diseases
edited by Edyta Juszczuk-Kubiak and Katarzyna Góralska
submission deadline 30 Jun 2026 | 6 articles | Viewed by 10149 | Submission Open
Keywords: microbiota; eubiosis; dysbiosis; microbiota– host interaction; microbiota– gut– brain axis; microbiome; bacteria– fungi interactions; microbiota modification; holobiont; cross-feeding; microbiota related diseases; microbiota functions
(This special issue belongs to the Section Microbiology)
Current Advances in Lung Cancer Diagnosis and Treatment
edited by , Daesik Yang and
submission deadline 30 Jun 2026 | 4 articles | Viewed by 7434 | Submission Open
Keywords: lung cancer; underlying lung disease; radiotherapy; systemic therapy; survival outcomes; complication; biomarkers
(This special issue belongs to the Section Medical Research)
Update on Microalgae Metabolites submission deadline 30 Jun 2026 | 2 articles | Viewed by 3251 | Submission Open
Keywords: biosynthesis; culture conditions; bioactive compounds; biological activity; biorefinery; proteins; peptides; antifreeze proteins; enzymes; carbohydrates; exocellular polysaccharides; carbohydrate-binding proteins; lipids; fatty acids; chlorophylls; carotenoids; phycobiliproteins; vitamins; minerals; trace elements; sterols; secondary metabolites; downstream processing; purification; safety; regulatory issues; clinical tests
(This special issue belongs to the Section Microbiology)
Musculoskeletal Imaging: Innovations in Diagnostics and Interventional Therapies
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2708 | Submission Open
Keywords: magnetic resonance imaging; bone and bones; computed tomography; sarcoma; interventional radiology
(This special issue belongs to the Section Medical Research)
Latest Updates on Clinical Microbiology and Antimicrobial Resistant Infection
edited by Jun Sung Hong
submission deadline 30 Jun 2026 | 2 articles | Viewed by 2693 | Submission Open
Keywords: enterobacteriaceae; antimicrobial resistance; infection; health
(This special issue belongs to the Section Microbiology)
Microalgae and Their Biotechnological Potential
edited by , Yi Xin and Yuanxue Liang
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2603 | Submission Open
Keywords: microalgae; biofuels; bioproducts; lipid metabolism; synthetic biology; system engineering
(This special issue belongs to the Section Microbiology)
Pathological and Clinical Updates on Eye Diseases
edited by Pier Luigi Surico and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1940 | Submission Open
Keywords: ophthalmology; eye diseases; gene therapy; ocular surface; ocular immunology; cornea
(This special issue belongs to the Section Medical Research)
Advances in Livestock Breeding, Nutrition and Metabolism
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1846 | Submission Open
Keywords: genetic selection; livestock breeding; genome editing; animal nutrition; precision feeding; nutritional additives; feed conversion; metabolism; animal health; sustainability
(This special issue belongs to the Section Animal Science)
Role of Machine and Deep Learning in Drug Screening
edited by and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1323 | Submission Open
Keywords: machine learning in drug screening; deep learning in drug discovery; virtual screening; molecular docking and dynamics; personalized medicine
(This special issue belongs to the Section Pharmaceutical Science)
Research on Gastrointestinal Cancer and Nutritional Health
edited by , Adam Mylonakis and Dimitrios Tsapralis
submission deadline 30 Jun 2026 | 1 articles | Viewed by 1272 | Submission Open
Keywords: dietary patterns; gastrointestinal cancer; clinical nutrition; nutritional status; nutritional assessment; metabolism; gastric cancer; esophageal cancer; pancreatic cancer; colorectal cancer
(This special issue belongs to the Section Medical Research)
Channel Proteins and Transporters in Human Health and Disease submission deadline 30 Jun 2026 | Viewed by 1054 | Submission Open
Keywords: channel proteins; transporters; ion channel
(This special issue belongs to the Section Proteins and Proteomics)
Perspectives on Nutrition and Livestock Health
edited by Liuting Wu, Yan Wang and
submission deadline 30 Jun 2026 | 1 articles | Viewed by 359 | Submission Open
Keywords: nutrition; animal health; animal reproductive; animal welfare; gut microbiome
(This special issue belongs to the Section Animal Science)
Neuroimaging and Integrative Analyses in Psychiatry and Addictive Disorders
edited by Arkadiusz Komorowski
submission deadline 30 Jun 2026 | Viewed by 347 | Submission Open
Keywords: psychiatry; neuroimaging; forensic psychiatry; fMRI; PET; EEG; addiction; substance use disorders (SUD); psychotherapy; treatment-resistant depression (TRD); attention deficit hyperactivity disorder (ADHD)
(This special issue belongs to the Section Physiology and Pathology)
New Advances in the Treatment and Assessment of Temporomandibular Joint Disorders submission deadline 30 Jun 2026 | Viewed by 304 | Submission Open
Keywords: orofacial dysfunction; multifactorial etiology; advanced diagnostic technologies; biomechanical modeling of TMJ; novel imaging techniques; inflammatory and degenerative changes; interdisciplinary management; conservative therapy approaches; occlusal concepts; splint therapy design; physical therapy regimens; long-term implant treatment outcomes; personalized treatment strategies
(This special issue belongs to the Section Medical Research)
Autoimmune Disorders: From Pathophysiology to Therapeutics
edited by and Chiara Mura
submission deadline 30 Jun 2026 | Viewed by 268 | Submission Open
Keywords: autoimmunity; autoimmune diseases; polyglandular autoimmune syndromes; thyroid autoimmune disease; type 1 diabetes
(This special issue belongs to the Section Physiology and Pathology)
Placental Spectrum Disorders and Gynecological Oncology
edited by Gianluca Raffaello Damiani
submission deadline 30 Jun 2026 | Viewed by 155 | Submission Open
Keywords: placenta; trophoblastic tumor; mola; tumors; bleeding
(This special issue belongs to the Section Medical Research)
Advances in Bioorganic and Medicinal Chemistry
edited by Sahar Kandil
submission deadline 30 Jun 2026 | Viewed by 145 | Submission Open
Keywords: medicinal chemistry; drug discovery; biological chemistry; therapeutic targets; therapeutic agents; treatment of diseases; new therapeutic strategies
Post-Concussion Syndrome and Functional Neurological Disorder submission deadline 30 Jun 2026 | Viewed by 140 | Submission Open
Keywords: post-concussion syndrome; functional neurological disorder; mild traumatic brain injury; cognitive dysfunction  ; neuroimaging; biomarkers; neurorehabilitation
(This special issue belongs to the Section Medical Research)
Applications of Dermatoscopy in Skin Diseases: 2nd Edition submission deadline 30 Jun 2026 | Viewed by 120 | Submission Open
Keywords: melanoma; skin cancer; inflammoscopy; trichoscopy; ultraviolet reflectance dermatoscopy; skin of color; basal cell carcinoma; squamous cell carcinoma; nevus; digital dermoscopy
(This special issue belongs to the Section Medical Research)
Transplant Medicine: Updates and Current Challenges
edited by Phillipe Abreu
submission deadline 30 Jun 2026 | Viewed by 97 | Submission Open
Keywords: robotic transplantation; organ transplants; transplant oncology
(This special issue belongs to the Section Medical Research)
Sleep-Disordered Breathing: Key Pathophysiological Mechanisms and Their Clinical Implications
edited by
submission deadline 30 Jun 2026 | Viewed by 91 | Submission Open
Keywords: sleep-disordered breathing; sleep fragmentation; inflammation; cardiovascular disease; insulin resistance
(This special issue belongs to the Section Physiology and Pathology)
Vector-Borne Diseases and One Health
edited by , Shayenne Silva and
submission deadline 30 Jun 2026 | Viewed by 82 | Submission Open
Keywords: vector-borne diseases; One Health; malaria; dengue; Zika; chikungunya; yellow fever; West Nile virus; Lyme disease; leishmaniasis; Chagas
(This special issue belongs to the Section Animal Science)
“Out-of-the-Organics-Box” Reflections On and Scenarios for Life’s Emergence
edited by
submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open
Keywords: emergence of life; thermodynamics; bioenergetics; information theory; early metabolism; metal ions in biochemistry
(This special issue belongs to the Section Origin of Life)
Advances and Challenges in Urothelial and Prostate Cancer: Toward Precision Urologic Oncology
edited by Sashi S. Kommu
submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open
Keywords: urothelial carcinoma; prostate cancer; immunotherapy; genomics and biomarkers; precision imaging (PSMA PET; mpMRI); targeted therapies (PARP; FGFR; DDR); focal therapy and theranostics; tumour microenvironment; quality of life and survivorship; health disparities in cancer care; artificial intelligence
(This special issue belongs to the Section Medical Research)
Physical Rehabilitation for Musculoskeletal Disorders: 2nd Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open
Keywords: physical rehabilitation; musculoskeletal disorders; pain management; range of motion; muscle strengthening; mobility enhancement; physical therapy; manual therapy; AI in rehabilitation
(This special issue belongs to the Section Medical Research)
Neural Mechanisms of Brain–Computer Interfaces
edited by
submission deadline 30 Jun 2026 | Viewed by 54 | Submission Open
Keywords: brain– machine interfaces; neurophysiology; somatosensory cortex; motor cortex
(This special issue belongs to the Section Physiology and Pathology)
Cranial Base Tumors: Pathogenesis, Diagnosis, and Treatments
edited by and Marcin Szymański
submission deadline 30 Jun 2026 | Viewed by 54 | Submission Open
Keywords: skull base tumors; neuro-oncology; endoscopic surgery; cranial nerve preservation; AI-assisted diagnostics; multidisciplinary management
(This special issue belongs to the Section Medical Research)
Mechanisms and Modulation of Pain: From Ion Channels to Translational Therapeutics
edited by Álvaro Yogi
submission deadline 30 Jun 2026 | Viewed by 51 | Submission Open
Keywords: pain; mechanisms; signaling pathways; ion channels; therapeutic targets; neuropathic pain; inflammatory pain; pre-clinical models
(This special issue belongs to the Section Pharmaceutical Science)
Comprehensive Treatment and Precision Medicine Strategies for Heart Disease
edited by Serge Sicouri
submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open
Keywords: precision medicine; artificial intelligence; risk stratification; machine learning; translational research; cardiovascular outcomes
(This special issue belongs to the Section Medical Research)
Extracellular Vesicles: Biology, Mechanisms, and Therapies for Cerebrovascular Disorders
edited by Jinju Wang
submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open
Keywords: extracellular vesicles; cerebrovascular disorders; dementia; extracellular vesicle-based therapy
(This special issue belongs to the Section Physiology and Pathology)
Drug Safety and Outcomes in Respiratory and Critical Care Medicine
edited by
submission deadline 30 Jun 2026 | Viewed by 31 | Submission Open
Keywords: drug safety; adverse drug reactions; pharmacovigilance; critical care medicine; respiratory diseases; clinical outcomes; intensive care pharmacotherapy; drug– drug interactions
(This special issue belongs to the Section Pharmaceutical Science)
Rewiring Bacterial Communication: Extracellular Vesicles and Microbial Signals Across Host Interfaces
edited by Sara Carloni
submission deadline 30 Jun 2026 | Viewed by 23 | Submission Open
Keywords: bacterial extracellular vesicles (bEVs); host– microbe communication; microbiota dynamics; immune modulation; translational applications
(This special issue belongs to the Section Microbiology)
Neurodegeneration Across Mechanisms, Epidemiology, and Emerging Therapies: Inflammation, Metabolism, Aging, and Neuromodulation
edited by Julian Benito Leon
submission deadline 30 Jun 2026 | Viewed by 23 | Submission Open
Keywords: neurodegeneration; neuroinflammation; metabolic dysfunction; aging and inflammaging; epidemiology; biomarkers; neuromodulation; transcranial magnetic stimulation (TMS)
(This special issue belongs to the Section Medical Research)
New Insights into Diagnosis and Therapeutic Strategies for Chronic Liver Diseases
edited by
submission deadline 20 Jul 2026 | 4 articles | Viewed by 7693 | Submission Open
Keywords: chronic liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); drug-induced liver injury (DILI); hepatocellular carcinoma; biomarkers of liver fibrosis; imaging of liver fibrosis; CEUS; novel therapeutic strategies for CLDs
(This special issue belongs to the Section Medical Research)
Herbal Extracts in Skin Health and Disease
edited by
submission deadline 20 Jul 2026 | Viewed by 114 | Submission Open
Keywords: herbal extracts; natural products; skin disorders; skin care
(This special issue belongs to the Section Pharmaceutical Science)
Emerging Knowledge on Human Immunodeficiency Virus submission deadline 22 Jul 2026 | 3 articles | Viewed by 19453 | Submission Open
Keywords: HIV; antiretroviral treatment; long-acting ART; pre-exposure prophylaxis; HIV surveillance; antiretroviral resistance; primary resistance; HIV epidemiology; special populations; cascade of care; HIV diagnosis
(This special issue belongs to the Section Medical Research)
Contemporary Therapeutic Strategies for Solid Tumors
edited by Chohao Lee
submission deadline 26 Jul 2026 | Viewed by 57 | Submission Open
Keywords: therapeutic strategies; survival analysis; solid tumors; cancer treatment; targeted therapy; immunotherapy; precision medicine; clinical outcomes; prognostic factors
(This special issue belongs to the Section Medical Research)
Promising Therapeutic Horizons for Regenerative Medicine in Animals submission deadline 28 Jul 2026 | Viewed by 240 | Submission Open
Keywords: stem cells; induced pluripotent stem cells (iPSCs); soft tissue engineering; in vivo and in vitro investigations; extracellular vesicles; preclinical studies; clinical studies; platelet-rich plasma; platelet-rich fibrin; cell-based therapy; cell-free therapy; orthopedics; cardiology
(This special issue belongs to the Section Animal Science)
Migraine and Headache: From Pathophysiological Aspects
edited by
submission deadline 30 Jul 2026 | 3 articles | Viewed by 3691 | Submission Open
Keywords: migraine; headache; pathophysiology; treatment; medication
(This special issue belongs to the Section Physiology and Pathology)
Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy
edited by Przemysław Kosinski
submission deadline 30 Jul 2026 | Viewed by 1008 | Submission Open
Keywords: fetal medicine; prenatal diagnosis; non-invasive prenatal testing (NIPT); fetal imaging; fetal therapy; fetal surgery; neonatal intensive care; genetic and genomic advances; perinatal outcomes; maternal-fetal health
(This special issue belongs to the Section Reproductive and Developmental Biology)
Recent Advances in Bone Biology
edited by Barbara Peruzzi, and Giulia Battafarano
submission deadline 30 Jul 2026 | Viewed by 328 | Submission Open
Keywords: bone tissue engineering; bone-targeted therapies; genetic bone diseases; bone mechanotransduction; bone cell pathophysiology; bone metabolism
(This special issue belongs to the Section Physiology and Pathology)
Migraine and Headache: From Clinical and Therapeutic Aspects
edited by
submission deadline 30 Jul 2026 | Viewed by 216 | Submission Open
Keywords: migraine; headache; treatment; medication
(This special issue belongs to the Section Medical Research)
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