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Life
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Crosstalk between the Vascular and Nervous Systems: From Development to...
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Crosstalk between the Vascular and Nervous Systems: From Development to Pathology

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 11122

Special Issue Editors

Dr. Ken-ichi Mizutani

E-Mail Website
Guest Editor
Laboratory of Stem Cell Biology, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University, 1-1-3 Minatojima, Chuo-ku, Kobe 650-8586, Japan
Interests: angiogenesis; neurogenesis; neocortex; extracellular matrix; vascular aging; brain aging; Alzheimer's disease
Dr. Satoru Yamagishi

E-Mail Website
Guest Editor
Department of Organ and Tissue Anatomy, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
Interests: axon guidance; neuronal development; neurogensis; Alzheimer's disease; lymphangiogenesis; angiogenesis
Dr. Hiroyasu Kidoya

E-Mail Website
Guest Editor
Department of Integrative Vascular Biology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Yoshida, Fukui 910-1193, Japan
Interests: angiogenesis; tumor vasculature; angiocrine factors; vascular remodeling; infectious diseases
Dr. Kei Nakayama

E-Mail Website
Guest Editor
Laboratory of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 6588558, Japan
Interests: intercellular communication; neurogenesis; cerebral ischemia; inflammation; neurodegenerative diseases

Special Issue Information

Dear Colleagues,

Vascular and neural networks often develop synchronously. The crosstalk between blood vessels and nerves plays essential roles in the regulation of diverse physiological functions. On the other hand, abnormalities in angiogenesis and vascularization are involved in the onset and progression of diseases such as cancer, Alzheimer's disease, and cerebral ischemia. However, to date, our knowledge of neuro-vascular interaction remains limited. Thus, in this Special Issue, we would like to cover new concepts in the crosstalk between the vascular and nervous systems from development to pathology. The submission of original research and review articles is welcome.

Dr. Ken-ichi Mizutani
Dr. Satoru Yamagishi
Dr. Hiroyasu Kidoya
Dr. Kei Nakayama
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  •  angiogenesis
  •  neurogenesis
  •  angiocrine factor
  •  vascular remodeling
  •  axon guidance
  •  neurodegenerative diseases
  •  infectious diseases
  •  tumor vasculature

Published Papers (3 papers)

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Research

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13 pages, 3263 KiB  
Article
Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice
by Chisato Watanabe, Hirotoshi Shibuya, Yusuke Ichiyama, Eiichi Okamura, Setsuko Tsukiyama-Fujii, Tomoyuki Tsukiyama, Shoma Matsumoto, Jun Matsushita, Takuya Azami, Yoshiaki Kubota, Masahito Ohji, Fumihiro Sugiyama, Satoru Takahashi, Seiya Mizuno, Masaru Tamura, Ken-ichi Mizutani and Masatsugu Ema
Life 2022, 12(11), 1730; https://doi.org/10.3390/life12111730 - 28 Oct 2022
Cited by 1 | Viewed by 2051
Abstract
Angiogenesis is a process to generate new blood vessels from pre-existing vessels and to maintain vessels, and plays critical roles in normal development and disease. However, the molecular mechanisms underlying angiogenesis are not fully understood. This study examined the roles of exocyst complex [...] Read more.
Angiogenesis is a process to generate new blood vessels from pre-existing vessels and to maintain vessels, and plays critical roles in normal development and disease. However, the molecular mechanisms underlying angiogenesis are not fully understood. This study examined the roles of exocyst complex component (Exoc) 3-like 2 (Exoc3l2) during development in mice. We found that Exoc3l1, Exoc3l2, Exoc3l3 and Exoc3l4 are expressed abundantly in endothelial cells at embryonic day 8.5. The generation of Exoc3l2 knock-out (KO) mice showed that disruption of Exoc3l2 resulted in lethal in utero. Substantial numbers of Exoc3l2 KO embryos exhibited hemorrhaging. Deletion of Exoc3l2 using Tie2-Cre transgenic mice demonstrated that Exoc3l2 in hematopoietic and endothelial lineages was responsible for the phenotype. Taken together, these findings reveal that Exoc3l2 is essential for cardiovascular and brain development in mice. Full article
(This article belongs to the Special Issue Crosstalk between the Vascular and Nervous Systems: From Development to Pathology)
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Review

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14 pages, 1671 KiB  
Review
The Multiple Roles of Pericytes in Vascular Formation and Microglial Functions in the Brain
by Yuki Hattori
Life 2022, 12(11), 1835; https://doi.org/10.3390/life12111835 - 09 Nov 2022
Cited by 8 | Viewed by 5247
Abstract
In the capillary walls, vascular endothelial cells are covered with mural cells, such as smooth muscle cells and pericytes. Although pericytes had been thought to play simply a structural role, emerging evidence has highlighted their multiple functions in the embryonic, postnatal, and adult [...] Read more.
In the capillary walls, vascular endothelial cells are covered with mural cells, such as smooth muscle cells and pericytes. Although pericytes had been thought to play simply a structural role, emerging evidence has highlighted their multiple functions in the embryonic, postnatal, and adult brain. As the central nervous system (CNS) develops, the brain’s vascular structure gradually matures into a hierarchical network, which is crucial for the proper development of neural lineage cells by providing oxygen and nutrients. Pericytes play an essential role in vascular formation and regulate blood‒brain barrier (BBB) integrity as a component of the neurovascular unit (NVU), in collaboration with other cells, such as vascular endothelial cells, astrocytes, neurons, and microglia. Microglia, the resident immune cells of the CNS, colonize the brain at embryonic day (E) 9.5 in mice. These cells not only support the development and maturation of neural lineage cells but also help in vascular formation through their extensive migration. Recent studies have demonstrated that pericytes directly contact microglia in the CNS, and their interactions have a profound effect on physiological and pathological aspects. This review summarizes the function of pericytes, focusing on the interplay between pericytes and microglia. Full article
(This article belongs to the Special Issue Crosstalk between the Vascular and Nervous Systems: From Development to Pathology)
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12 pages, 1830 KiB  
Review
Crosstalk between Blood Vessels and Glia during the Central Nervous System Development
by Hidenori Tabata
Life 2022, 12(11), 1761; https://doi.org/10.3390/life12111761 - 01 Nov 2022
Cited by 3 | Viewed by 2578
Abstract
The formation of proper blood vessel patterns in the central nervous system (CNS) is crucial to deliver oxygen and nutrient to neurons efficiently. At the same time, neurons must be isolated from the outer blood circulation by a specialized structure, the blood–brain barrier [...] Read more.
The formation of proper blood vessel patterns in the central nervous system (CNS) is crucial to deliver oxygen and nutrient to neurons efficiently. At the same time, neurons must be isolated from the outer blood circulation by a specialized structure, the blood–brain barrier (BBB), to maintain the microenvironment of brain parenchyma for the survival of neurons and proper synaptic transmission. To develop this highly organized structure, glial cells, a major component of the brain, have been reported to play essential roles. In this review, the crosstalk between the macroglia, including astrocytes and oligodendrocytes, and endothelial cells during the development of CNS will be discussed. First, the known roles of astrocytes in neuro-vascular unit and its development, and then, the requirements of astrocytes for BBB development and maintenance are shown. Then, various genetic and cellular studies revealing the roles of astrocytes in the growth of blood vessels by providing a scaffold, including laminins and fibronectin, as well as by secreting trophic factors, including vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) are introduced. Finally, the interactions between oligodendrocyte progenitors and blood vessels are overviewed. Although these studies revealed the necessity for proper communication between glia and endothelial cells for CNS development, our knowledge about the detailed cellular and molecular mechanisms for them is still limited. The questions to be clarified in the future are also discussed. Full article
(This article belongs to the Special Issue Crosstalk between the Vascular and Nervous Systems: From Development to Pathology)
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