Regeneration: Biology and Medicine

Dear Colleagues,

The role of regeneration in the maintenance of life and the normal functioning of the organism is hard to overestimate. Usually, researchers distinguish two types of regeneration: physiological and reparative. However, the interconnection of these two types is poorly understood. Physiological regeneration is based on proliferation, cellular polyploidy, hypertrophy, and intracellular organelle renewal. A classic example of a reparative type is limb regeneration in amphibians. Regeneration in hydra and planaria has historically been used as examples of classical reparative regeneration; however, it needs to be studied in other models, including mammals. Despite the greater variety of reparative regeneration forms—the participation of macrophages, cellular dedifferentiation, activation of progenitor cells in the damaged organ—all regeneration mechanisms have common features. Macrophages are key players in tissue homeostasis. More and more research is now directed towards reprogramming macrophages to stimulate regeneration. Regenerative medicine is undergoing a surge in research with the discovery of embryonic stem cells, induced pluripotent stem cells and the study of their role in the repair of damaged tissue. In this regard, this Special Issue proposes to provide data on the mechanisms of regeneration of vertebrates and invertebrates. Given the importance of the topic, in addition to fundamental works, the submission of applied works on methods of stimulating regeneration using stem cells, methods of tissue and genetic engineering, and cellular technologies is encouraged.

Dr. Andrey Elchaninov
Dr. Timur Fatkhudinov
Prof. Dr. Egor Yu. Plotnikov
Guest Editors

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