Mitochondrial Mechanisms of Oxidative Stress and Endothelial Dysfunction
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 11278
Special Issue Editors
Interests: cell metabolism; endothelial physiology and dysfunction; mitochondrial role in response to stress; bioenergetics; mitochondrial network architecture, oxidative stress; inflammatory response; intercellular communication; prosurvival cell response to stress
Interests: metabolism; mitochondria; bioenergetics; calcium signaling; vascular endothelium; muscle differentiation
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Special Issue Information
Dear Colleagues,
The vascular endothelium is a metabolically active tissue that produces and secretes a number of factors responsible for the regulation of blood vessel relaxation/constriction processes. In the endothelium, the oxidative stress that accompanies metabolic defects in a variety of cells affects vascular tone by reducing NO bioavailability. Among the several sources of cellular ROS, the mitochondrial respiratory chain and NAD(P)H oxidase play leading roles. Mitochondria are the main source of ATP in the vast majority of mammalian cells, but in the endothelial ones, ATP is mainly delivered by glycolysis, while the mitochondria have a role in the regulation of cellular signaling, particularly as a source of reactive oxygen species and in the dynamic buffering of calcium ions. Consequently, they modulate NO generation and inflammatory responses, which are among the most critical functions of the endothelium. Therefore, mitochondrial stress or disturbances in mitochondrial metabolism, which often result in excessive ROS generation, may lead to endothelial dysfunction, vascular abnormalities and, eventually, cardiovascular diseases.
This Special Issue aims to gather original research articles and review articles focusing on the mitochondrial mechanisms involved in the response to stress stimuli and the development and progression of a number of pathologies including endothelial dysfunction.
Dr. Dorota Dymkowska
Prof. Dr. Krzysztof Zabłocki
Guest Editors
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Keywords
- mitochondrial metabolism
- reactive oxygen species
- oxidative stress
- mitochondrial response to stress stimuli
- inflammatory response
- endothelial mitochondria
- endothelial dysfunction
- cardiovascular diseases
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