Key Achievements of the Last Decade and Future Prospects in Cardiovascular Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (1 June 2022) | Viewed by 2467

Special Issue Editor


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Guest Editor
Department of Internal Medicine I-Medical Semiology I, Universitatea de Medicina si Farmacie Victor Babes din Timisoara, 300041 Timisoara, Romania
Interests: cardiology;cardiovascular disease

Special Issue Information

Dear Colleagues,

In the last decade, cardiology has made many advances with the results of intensive research and evidence-based medicine allowing us to have a more robust knowledge base. Progress is being made both in terms of the diagnosis and understanding of cardiovascular pathology, and in terms of treatment, exemplified by the development of minimally invasive technologies that have enabled more patients to be treated for heart problems successfully. Among the greatest accomplishments have been the replacement of surgical approaches by percutaneous methods for almost all types of structural heart disease.

Progress in treatment was made through the emergence of new drugs or by better understanding old ones. One such treatment is the use of non-vitamin K antagonists in the cardiovascular field for stroke prevention and venous thombo-embolic disease, for which we have now four non-vitamin K oral anticoagulants as alternatives to the only treatment that was previously available, warfarin. Perhaps the most stunning pharmacological developments have been the PCSK9 inhibitors (alirocumab and evolocumab), which dramatically lower LDL-cholesterol and sacubitril/valsartan or SGLT2, which reduces risk of cardiovascular death and heart-failure-related hospitalization as well as GLP-1RA in diabetic patients with cardiovascular pathology.

Recent years have also been marked by the development of new branches such as cardio-oncology to find a balance between the effectiveness of cancer treatment and the prevention of cardiovascular complications, which are currently extremely numerous.

In this Special Issue, we will summarize the achievements of the last decade and forecast the future in cardiovascular disease. We welcome communications, reviews and original research articles.

Prof. Dr. Daniel Lighezan
Guest Editor

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Keywords

  • cardiovascular
  • heart disease
  • anticoagulants
  • dyslipidemia
  • treatment

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Published Papers (1 paper)

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Research

14 pages, 1513 KiB  
Article
B-Cell Activating Factor Increases Related to Adiposity, Insulin Resistance, and Endothelial Dysfunction in Overweight and Obese Subjects
by Diana Carolina Villalpando Sánchez, Sergio Gutiérrez Castellanos, Martha Eva Viveros Sandoval and Anel Gómez García
Life 2022, 12(5), 634; https://doi.org/10.3390/life12050634 - 25 Apr 2022
Cited by 4 | Viewed by 2102
Abstract
Obesity (OB) is a major healthcare problem that results from long-term energy imbalance. Adipokines and pro-inflammatory cytokines facilitate adipose tissue (AT) remodeling to safely store excess nutrients. B-cell activating factor (BAFF) is a newly described adipokine whose role in enhancing adipogenesis has been [...] Read more.
Obesity (OB) is a major healthcare problem that results from long-term energy imbalance. Adipokines and pro-inflammatory cytokines facilitate adipose tissue (AT) remodeling to safely store excess nutrients. B-cell activating factor (BAFF) is a newly described adipokine whose role in enhancing adipogenesis has been reported. The present study aimed to evaluate serum BAFF association with adiposity distribution, serum adipokines, pro-inflammatory cytokines, and metabolic and endothelial dysfunction markers. The study included 124 young Mexican adults with no diagnosed comorbidities, divided according to their BMI. Anthropometric measurements, blood counts, and serum molecules (i.e., glucose, lipid profile, insulin, leptin, pro- and anti-inflammatory cytokines, von Willebrand factor (vWF), and BAFF) were assessed. The analysis showed positive correlation between BAFF and increased fat mass in all anthropometric measurements (p < 0.0001). BAFF augmentation was related to systemic inflammatory environment (p < 0.05), and linked with insulin resistance status (p < 0.05). BAFF increment was also correlated with early endothelial damage markers such as vWF (p < 0.0001). Linear regression analysis showed a role for BAFF in predicting serum vWF concentrations (p < 0.01). In conclusion, our data show that BAFF is an adipokine dynamically related to OB progression, insulin resistance status, and systemic inflammatory environment, and is a predictor of soluble vWF augmentation, in young overweight and obese Mexican subjects. Full article
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