Tumor–Host Interaction during Cancer Progression

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".

Deadline for manuscript submissions: closed (20 May 2022) | Viewed by 3219

Special Issue Editors


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Guest Editor
Department of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan
Interests: tumor microenvironment; extracellular vesicles; cancer therapy; biomarkers

E-Mail Website
Guest Editor
Graduate Institute of Medical Science, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
Interests: oncology; epigenetics; noncoding RNAs

Special Issue Information

Dear Colleagues,

The tumor–host interaction in a dynamic tumor microenvironment (TME) modulates therapeutic efficacy and is now the most complex challenge faced in the development of an effective cure for cancer. Although remarkable advances in cancer treatment have been made in recent years, the precise molecular interplay underlying localized cancer subpopulations and tumor-infiltrated host cells is not fully understood. A deeper understanding of TME features is required for developing feasible platforms to detect tumor–host interaction as part of therapeutic schemes, which will lead to a more effective therapeutic strategy to overcome cancer resistance. This Special Issue will summarize the latest translational research, including research articles and comprehensive review articles on molecular and cellular mechanisms involved in tumor–host interaction. Submissions can be focused on tissue samples, animal models or cell experiments. Descriptions of single-cell sequencing, multiplex imaging or other molecular techniques that can be used to help define the tumor–host interaction are of interest. Articles can discuss both leukemia as well as solid tumors.

Keywords

  • tumor microenvironment
  •  tumor-host interaction
  •  cancer therapy
  •  biomarker identification
  •  precision medicine

Published Papers (1 paper)

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Review

18 pages, 1109 KiB  
Review
Macrophages in Glioblastoma Development and Therapy: A Double-Edged Sword
by Mengwan Wu, Ying Shi, Luyi Zhu, Luoyi Chen, Xinchen Zhao and Chuan Xu
Life 2022, 12(8), 1225; https://doi.org/10.3390/life12081225 - 12 Aug 2022
Cited by 5 | Viewed by 2767
Abstract
Glioblastoma (GBM) is one of the leading lethal tumors, featuring aggressive malignancy and poor outcome to current standard temozolomide (TMZ) or radio-based therapy. Developing immunotherapies, especially immune checkpoint inhibitors, have improved patient outcomes in other solid tumors but remain fatigued in GBM patients. [...] Read more.
Glioblastoma (GBM) is one of the leading lethal tumors, featuring aggressive malignancy and poor outcome to current standard temozolomide (TMZ) or radio-based therapy. Developing immunotherapies, especially immune checkpoint inhibitors, have improved patient outcomes in other solid tumors but remain fatigued in GBM patients. Emerging evidence has shown that GBM-associated macrophages (GAMs), comprising brain-resident microglia and bone marrow-derived macrophages, act critically in boosting tumor progression, altering drug resistance, and establishing an immunosuppressive environment. Based on its crucial role, evaluations of the safety and efficacy of GAM-targeted therapy are ongoing, with promising (pre)clinical evidence updated. In this review, we summarized updated literature related to GAM nature, the interplay between GAMs and GBM cells, and GAM-targeted therapeutic strategies. Full article
(This article belongs to the Special Issue Tumor–Host Interaction during Cancer Progression)
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