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Life
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Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications
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Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 August 2026 | Viewed by 1515

Special Issue Editor

Dr. Chien-Hung Lin

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Guest Editor
Division of Pediatric Immunology and Nephrology, Department of Pediatrics, Taipei Veterans General Hospital, Taipei 11221, Taiwan
Interests: acute and chronic kidney disease; early prediction; molecular diagnosis; precision therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the pathological features and complications arising in patients undergoing hemodialysis (HD) and peritoneal dialysis (PD). It aims to provide a comprehensive understanding of the structural and functional changes associated with long-term dialysis, with particular attention on cardiovascular complications, vascular pathology including arteriovenous fistula (AVF) alterations, and morphological changes in the peritoneal membrane in chronic PD patients.

We welcome contributions that explore the mechanisms and histopathological findings of dialysis-associated infections, dialysis-related organ damage, and the role of tissue pathology in informing clinical decision-making. By highlighting the intersection between clinical nephrology and pathology, this issue seeks to deliver practical insights for researchers and clinicians involved in the management of dialysis-related complications.

Dr. Chien-Hung Lin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • peritoneal dialysis
  • hemodialysis
  • acute kidney injury (AKI)
  • chronic kidney disease
  • pathology
  • complication

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Published Papers (2 papers)

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Research

15 pages, 269 KB  
Article
Elevated p-Cresyl Sulfate Levels Are Associated with Impaired Endothelial Function in Patients Undergoing Long-Term Peritoneal Dialysis
by I-Min Su, Bang-Gee Hsu, Chin-Hung Liu, Ho-Hsiang Chang and Ming-Chun Chen
Life 2026, 16(5), 787; https://doi.org/10.3390/life16050787 - 8 May 2026
Abstract
p-Cresyl sulfate (PCS) is associated with endothelial injury and adverse cardiovascular outcomes. However, its association with endothelial function in patients on peritoneal dialysis (PD) remains unclear. In this cross-sectional study, 82 patients receiving PD were enrolled. Serum PCS concentrations were quantified using high-performance [...] Read more.
p-Cresyl sulfate (PCS) is associated with endothelial injury and adverse cardiovascular outcomes. However, its association with endothelial function in patients on peritoneal dialysis (PD) remains unclear. In this cross-sectional study, 82 patients receiving PD were enrolled. Serum PCS concentrations were quantified using high-performance liquid chromatography–mass spectrometry. Endothelial function was evaluated by digital thermal monitoring (DTM), and vascular reactivity was stratified based on vascular reactivity index (VRI) values into good (>2.0), intermediate (1.0–1.9), and poor (<1.0). Overall, 46.3%, 43.9%, and 9.8% of participants had poor, intermediate, and good vascular reactivity, respectively. Poor reactivity was associated with a higher prevalence of diabetes (p = 0.018), old age (p < 0.001), higher waist circumference (p = 0.013), serum C-reactive protein levels (p = 0.010), and PCS levels (p < 0.001) and lower diastolic blood pressure (p = 0.032) and serum creatinine levels (p = 0.005). Higher serum log-transformed PCS levels were associated with reduced VRI after adjustment for covariates (p < 0.001). In multivariable models adjusted for potential confounders, PCS was independently associated with poor vascular reactivity (p = 0.029), with consistent findings observed across penalized regression analyses (all p < 0.001). An inverse relationship was observed between serum PCS levels and endothelial function in patients undergoing PD. Full article
(This article belongs to the Special Issue Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications)
10 pages, 419 KB  
Article
Association of Phase Angle with Body Composition in Hemodialysis Patients: A Case–Control Study
by Selma Cvijetić Avdagić, Petra Kovačević Totić, Karla Kovačević Čorak, Antonija Sulimanec and Karmela Altabas
Life 2025, 15(11), 1666; https://doi.org/10.3390/life15111666 - 25 Oct 2025
Cited by 1 | Viewed by 1077
Abstract
Patients on hemodialysis (HD) often experience changes in body composition due to metabolic disorders. Phase angle (PhA) is a marker of tissue integrity and may reflect overall functional condition. This study evaluated body composition and its relationship with PhA in 53 HD patients [...] Read more.
Patients on hemodialysis (HD) often experience changes in body composition due to metabolic disorders. Phase angle (PhA) is a marker of tissue integrity and may reflect overall functional condition. This study evaluated body composition and its relationship with PhA in 53 HD patients (27 women, 26 men) over 40 years old, compared with 106 age- and sex-matched healthy controls. Body composition was assessed using bioelectrical impedance analysis (BIA), measuring skeletal muscle mass (SMM), fat tissue, total bone mass (BM), and PhA. HD patients had significantly lower fat mass and PhA than controls (p < 0.001). The prevalence of low SMM and BM was higher in patients, though not statistically significant. Sex differences were generally not significant, except for a higher prevalence of low BM in female controls (p < 0.001). After adjusting for age and sex, PhA was positively associated with SMM% (p = 0.021) and BM (p = 0.035) in HD patients only. These results indicate that PhA–body composition relationships differ between HD patients and healthy individuals, highlighting PhA as a potential marker of body composition disturbances in HD. Full article
(This article belongs to the Special Issue Advances in Dialysis Pathology: Insights into Peritoneal and Hemodialysis Complications)
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