The Dynamic Tumor Microenvironment: Mechanisms of Therapy Resistance and Opportunities for Intervention
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".
Deadline for manuscript submissions: 20 January 2027 | Viewed by 117
Special Issue Editors
Interests: combination immunotherapy; tumor immune microenvironment remodeling; in situ vaccination
Special Issues, Collections and Topics in MDPI journals
Interests: cytokines; breast cancer; exosomes; dormancy; aging; glioblastoma; hematopoiesis; miRNA; neural-hematopoiesis axis; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The dynamics of the tumor microenvironment (TME) have recently emerged as critical for understanding the deep mechanisms of therapeutic resistance and have enabled a unique approach, offering novel and more efficient therapeutic strategies. Comprising a complex interplay of tumor cells with many normal cell types, including immune cells, vascular networks, and extracellular matrix, the TME dynamically adapts to therapeutic pressure, fostering resistance through metabolic reprogramming, immune evasion, and altered signaling crosstalk. Recent advances have shown pivotal cellular and molecular interactions within the TME, highlighting how communications between malignant and non-malignant cells sculpt treatment outcomes. Understanding these mechanisms in the TME provides novel perspectives for a better intervention, ranging from adapting cell signalization, immune regulations, to metabolic control. This Special Issue, “The Dynamic Tumor Microenvironment: Mechanisms of Therapy Resistance and Opportunities for Intervention”, aims to assemble new insights on TME-driven resistance and propose novel strategies toward durable and best clinical outcomes.
You may choose our Joint Special Issue in Cells.
Dr. Ahmed Lasfar
Prof. Dr. Pranela Rameshwar
Guest Editors
Manuscript Submission Information
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Keywords
- tumor microenvironment/TME
- therapeutic resistance
- mechanisms
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