Phosphorus in the Origin of Life

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Origin of Life".

Deadline for manuscript submissions: closed (15 February 2020) | Viewed by 3808

Special Issue Editors


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Guest Editor
Department of Geology and Geophysics, Yale University, New Haven, CT 06520, USA
Interests: stable isotope geobiochemistry; geomicrobiology; astrobiology; phosphoenzymes; PO4 biomarkers; deep biosphere and subseafloor life

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Guest Editor
Department of Geology, University of South Florida, Tampa, FL, USA
Interests: astrobiology; geochemistry; cosmochemistry; origins of life; prebiotic chemistry

Special Issue Information

Dear Colleagues,

Life as we know it would not exist without phosphorus (P). From structural to functional, informational, and energetic roles, P is absolutely essential to life. This Special Issue, “Phosphorus in the Origins of Life”, aims to explore the roles that P plays at and leading up to life’s first beginnings. What were the key forms of P (e.g., mineral, meteoric, organic, reduced) in the early Earth environments that led to the basic building blocks for life? What were the crucial steps and mechanisms in their synthesis and catalysis? What are the alternatives and analogues to P-based life? How can our Earth model guide our understanding of the co-evolution of life and P biochemistry on other worlds? These are questions that require an integrated and multidisciplinary approach including but not limited to biochemistry, microbiology, biophysics, geology, astrobiology, mathematical modeling, and astronomy. We invite you to contribute to this Special Issue with an article that addresses one of these questions or a related question on prebiotic P synthesis, alternative sources of P for life, etc.

Prof. Dr. Ruth E. Blake
Dr. Matthew Pasek
Guest Editors

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Keywords

  • phosphorus/phosphate
  • prebiotic synthesis
  • phosphoesters
  • apatite
  • reduced P/phosphite
  • RNA world
  • ATP
  • polyphosphate

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Published Papers (1 paper)

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Research

12 pages, 3103 KiB  
Article
Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments
by Radosław W. Piast, Maciej Garstka, Aleksandra Misicka and Rafał M. Wieczorek
Life 2020, 10(7), 103; https://doi.org/10.3390/life10070103 - 2 Jul 2020
Cited by 4 | Viewed by 3235
Abstract
All life on Earth uses one universal biochemistry stemming from one universal common ancestor of all known living organisms. One of the most striking features of this universal biochemistry is its utter dependence on phosphate group transfer between biochemical molecules. Both nucleic acid [...] Read more.
All life on Earth uses one universal biochemistry stemming from one universal common ancestor of all known living organisms. One of the most striking features of this universal biochemistry is its utter dependence on phosphate group transfer between biochemical molecules. Both nucleic acid and peptide biological synthesis relies heavily on phosphate group transfer. Such dependents strongly indicate very early incorporation of phosphate chemistry in the origin of life. Perhaps as early as prebiotic soup stage. We report here on a short cyclic peptide, c(RPDDHR), designed rationally for pyrophosphate interaction, which is able to create a new amide bond dependent on the presence of pyrophosphate. We believe this result to be a first step in the exploration of Phosphate Transfer Catalysts that must have been present and active in prebiotic soup and must have laid down foundations for the universal bioenergetics. Full article
(This article belongs to the Special Issue Phosphorus in the Origin of Life)
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