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Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments

1
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland
2
Department of Metabolic Regulation, Faculty of Biology, University of Warsaw, Miecznikowa 1, 02-096 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Life 2020, 10(7), 103; https://doi.org/10.3390/life10070103
Received: 7 April 2020 / Revised: 23 June 2020 / Accepted: 28 June 2020 / Published: 2 July 2020
(This article belongs to the Special Issue Phosphorus in the Origin of Life)
All life on Earth uses one universal biochemistry stemming from one universal common ancestor of all known living organisms. One of the most striking features of this universal biochemistry is its utter dependence on phosphate group transfer between biochemical molecules. Both nucleic acid and peptide biological synthesis relies heavily on phosphate group transfer. Such dependents strongly indicate very early incorporation of phosphate chemistry in the origin of life. Perhaps as early as prebiotic soup stage. We report here on a short cyclic peptide, c(RPDDHR), designed rationally for pyrophosphate interaction, which is able to create a new amide bond dependent on the presence of pyrophosphate. We believe this result to be a first step in the exploration of Phosphate Transfer Catalysts that must have been present and active in prebiotic soup and must have laid down foundations for the universal bioenergetics. View Full-Text
Keywords: origin of life; peptides; pyrophosphate; prebiotic ecology; metallopeptides origin of life; peptides; pyrophosphate; prebiotic ecology; metallopeptides
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Piast, R.W.; Garstka, M.; Misicka, A.; Wieczorek, R.M. Small Cyclic Peptide for Pyrophosphate Dependent Ligation in Prebiotic Environments. Life 2020, 10, 103.

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