Metabolic Adaptations to Environmental Pressure

Dear colleagues,

Energy and nutrient fluctuations require finely regulated metabolic systems. Much of the development and evolution of these systems has taken place in the absence of pressures that we now experience as modern humans, including nutrient overload, lack of physical activity, and exposure to thermoneutral conditions and radiations. Overall, these environmental inputs ignite adaptive responses, which persist dramatically due to both increase in life expectancy and chronic lifetime exposure to stress signals. A metabolic pressure is then generated that, if continuous, may lead to metabolic and immunological failure, thus causing reduced tolerance to glucose and infections. In fact, biological responses are unable to cope with these challenges, and homeostatic systems gradually deteriorate.

For this Life Special Issue, submissions are encouraged to discuss how metabolic workload can modulate stress tolerance and to identify the molecular checkpoints governing the adaptive responses. Novel strategies aimed at restoring metabolic homeostasis under conditions of metabolic pressure are also welcome.

Dr. Daniele Lettieri-Barbato
Guest Editor

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