Comprehensive Care for Critically Ill Children: A Multidisciplinary Approach

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 3266

Special Issue Editor

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Guest Editor
Department of Morphofunctional Sciences I—Pathology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iaşi, Romania
Interests: tumoral and non-tumoral pediatric pathology; pain management; cardiovascular disease

Special Issue Information

Dear Colleagues,

The management of pediatric critical patients is an extremely difficult task, as a child's physiopathology is quite different from an adult's. If we look at pediatric patients from the newborn period, sometimes premature, and up to the age of 16, or from the weight of a few hundred grams up to one-hundred kilograms, we realize the wide and varied spectrum of pediatric critical patients. Such patients can only be treated in the multidisciplinary team, especially since the pediatric pathology is at least as extensive as that of the adult. In this Special Issue on the multidisciplinary management of critically ill pediatric patient, we include original articles, reviews, and even case reports on these important topics, among various others.

  • Managing pediatric multiple injury patients requires a good understanding of the distinct anatomy and pathophysiology of a child compared to those of an adult. Initial evaluation and resuscitation, as well as hospital management, are performed by a multidisciplinary team (including pediatric and trauma surgeons, plastic surgeons, intensive care physicians, radiologists, and psychologists).
  • Pediatric acute respiratory distress syndrome is associated with high morbidity and mortality rates, but, until recently, no pediatric-specific diagnostic and management criteria existed. These children require ventilator support in intensive care units, and the treatment team will include a pediatrician, an intensive care doctor, a radiologist, and sometimes a thoracic surgeon and an infectious disease doctor.
  • Congenital malformations comprise a wide and fascinating field, often associated with prematurity and low birth weights. Long-term hospitalization in neonatal intensive care units is an additional risk factor for morbidity, favoring the occurrence of neonatal sepsis. It is important to mention the need that these patients require treatment in a multidisciplinary team.
  • The multimodal and multidisciplinary treatment of malignant tumors in children is another area that deserves special attention. Cancer is a terrifying disease regardless of age, but when it occurs in a child, the psychosocial and ethical implications are all the more profound.

We invite scientists from all pediatric specialties to express their opinion and to showcase their studies performed on pediatric patients with severe conditions.

Dr. Elena Cojocaru
Guest Editor

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  • pediatric patient
  • neonate
  • congenital malformation
  • sepsis
  • acute respiratory syndrome
  • polytrauma
  • oncology
  • multidisciplinary management

Published Papers (1 paper)

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17 pages, 708 KiB  
Atherosclerosis from Newborn to Adult—Epidemiology, Pathological Aspects, and Risk Factors
by Alina Costina Luca, Simona Georgiana David, Alexandru Gabriel David, Viorel Țarcă, Ioana-Alexandra Pădureț, Dana Elena Mîndru, Solange Tamara Roșu, Eduard Vasile Roșu, Heidrun Adumitrăchioaiei, Jana Bernic, Elena Cojocaru and Elena Țarcă
Life 2023, 13(10), 2056; - 14 Oct 2023
Cited by 9 | Viewed by 2818
Cardiovascular disease is the leading cause of mortality and morbidity throughout the world, accounting for 16.7 million deaths each year. The underlying pathological process for the majority of cardiovascular diseases is atherosclerosis, a slowly progressing, multifocal, chronic, immune-inflammatory disease that involves the intima [...] Read more.
Cardiovascular disease is the leading cause of mortality and morbidity throughout the world, accounting for 16.7 million deaths each year. The underlying pathological process for the majority of cardiovascular diseases is atherosclerosis, a slowly progressing, multifocal, chronic, immune-inflammatory disease that involves the intima of large and medium-sized arteries. The process of atherosclerosis begins in childhood as fatty streaks—an accumulation of lipids, inflammatory cells, and smooth muscle cells in the arterial wall. Over time, a more complex lesion develops into an atheroma and characteristic fibrous plaques. Atherosclerosis alone is rarely fatal; it is the further changes that render fibrous plaques vulnerable to rupture; plaque rupture represents the most common cause of coronary thrombosis. The prevalence of atherosclerosis is increasing worldwide and more than 50% of people with circulatory disease die of it, mostly in modern societies. Epidemiological studies have revealed several environmental and genetic risk factors that are associated with the early formation of a pathogenic foundation for atherosclerosis, such as dyslipidemia, hypertension, diabetes mellitus, obesity, and smoking. The purpose of this review is to bring together the current information concerning the origin and progression of atherosclerosis in childhood as well as the identification of known risk factors for atherosclerotic cardiovascular disease in children. Full article
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