Role of Mitochondria in the Pathophysiology of Cardiovascular Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 145

Special Issue Editors


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Guest Editor
Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA
Interests: cardiac energy metabolism; mitochondrial calcium; mitochondrial dysfunction; mitochondrial ROS; redox homeostasis; calcium handling; calcium alternans; arrhythmias; atrial fibrillation; ischemia–reperfusion injury; heart failure

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Guest Editor
Institute for Obesity Research, Tecnologico de Monterrey, Monterrey, Mexico
Interests: mitochondrial uniporter channel; calcium handling; ischemia–reperfusion injury; heart failure; cardiac metabolism; redox homeostasis; mitochondrial ROS

Special Issue Information

Dear Colleagues,

Cardiovascular diseases (CVDs) are one of the leading causes of death, responsible for a third of all deaths globally. The heart is the most metabolically active organ as cardiac muscle contraction and relaxation both highly demand ATP production, which is mainly supplied by oxidative phosphorylation in the mitochondria. However, mitochondria serve roles beyond ATP biosynthesis, including the regulation of redox homeostasis, reactive oxygen species (ROS) signaling, cell death, ion homeostasis and inflammation.

Mitochondrial dysfunction has been recognized as pivotal in the pathogenesis and progression of CVDs, such as atherosclerosis, cardiac hypertrophy, myocardial infarction, ischemia–reperfusion injury and heart failure. This dysfunction encompasses defects in mitochondrial respiratory chain function, metabolic substrate utilization, mitochondrial network organization and dynamics, mitophagy, biogenesis and redox signaling. Moreover, impaired mitochondrial ROS handling alters cellular ion homeostasis, critical for cardiac electrophysiology, thereby increasing the propensity for cardiac arrhythmias. A deeper understanding of mitochondria and their role in the molecular mechanisms underlying CVDs is imperative for the development of therapeutic strategies.

This Special Issue will focus on the role of mitochondrial dysfunction in the development and progression of CVDs.

Dr. Yuriana Oropeza-Almazán
Dr. Héctor Chapoy-Villanueva
Guest Editors

Manuscript Submission Information

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Keywords

  • cardiovascular diseases (CVDs)
  • mitochondria
  • mitochondrial dysfunction
  • ATP production
  • mitochondrial fission
  • mitochondrial fusion
  • electron transport chain
  • oxidative phosphorylation
  • mitophagy
  • cardiac hypertrophy
  • myocardial infarction
  • IR injury
  • mitochondrial ROS
  • ROS signaling
  • ion homeostasis
  • cardiac arrhythmias

Published Papers

This special issue is now open for submission.
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