Modern Biological Applications of Nanoparticles: From Targeted Drug Delivery to Nanotheranostic and Beyond

Dear Colleagues,

Recently, the concept of nanomedicine has been of increasing research interest, which has allowed a number of problems to be solved related to the effective therapy of a number of malignant tumors and other diseases. However, the promotion of this concept is impossible without the improvement of our understanding of the peculiarities of the interaction between nanoparticles and living systems. The mechanisms of interaction between nanoparticles and body proteins in the development of targeted nanoparticle delivery remain among these unresolved issues. An important level of interaction for nanoparticles in living systems is the spectrum of possible interactions with different types of cells and systems, especially with the circulatory system. Therefore, in this Special Issue we welcome publications that present current approaches to noninvasive dynamic studies of the vascular system and hemodynamic parameters, which can contribute toward optimizing targeted nanoparticle delivery.

Theranostics is one of the most promising areas in modern biomedicine, combining tumor diagnosis and therapy. To implement this approach, nanoparticles carrying a tag for tumor imaging in addition to an antitumor agent are typically used. At the same time, an important fundamental problem remains the study of the interaction of such nanoparticles with living systems—both at the level of the individual cell and the entire organism. In particular, it is necessary to select such properties of nanoparticles that would ensure their prolonged circulation in the bloodstream, targeted accumulation in the tumor, minimal toxicity to normal cells, high contrast in imaging and significant anti-tumor effect. This Special Issue will therefore also include papers reflecting current advances in the application of nanoscale materials for research.

Dr. Dmitry Khochenkov
Dr. Evgeny Khaydukov
Guest Editors

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• nanoparticles
• theranostics
• biophotonics
• antistokes nanoparticles
• in vivo imaging
• solid tumors
• three-dimensional cell models
• tumor microenvironment