Stem Cells in Regeneration and Diseases
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Cell Biology and Tissue Engineering".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5270
Special Issue Editor
Interests: cancer biology; gene regulation; stem cell culture; stem cell differentiation; stem cells; cell culture; molecular cell biology; gene expression; regenerative medicine; stem cell biology
Special Issue Information
Dear Colleagues,
Stem cells, either embryonic, adult, or of engineered origin (e.g., iPS cells), have been used extensively in many research directions in recent decades. In addition, owing to their unique ability of self-renewal and long-term proliferation as well as differentiation, stem cells have become not only major players in regenerative medicine but also potential targets of diseases. However, despite our efforts in understanding the physiology and pathophysiology of stem cells, the molecular mechanisms underlying the self-renewal, proliferation, and differentiation of each stem cell type are not well-understood. In addition, the double standard in the understanding of stem cell behavior between in vivo (largely quiescent) and in vitro (hyperproliferative in general) settings masks the ‘true face’ of stem cells. The involvement of a ‘stem cell niche’ may help our understanding of a switch that controls the quiescence and proliferation of stem cells. However, positive and negative feedback loop mechanisms between stem cells and stem cell niches also increase the complexity of stem cell regulation.
This Special Issue will address the most advanced knowledge of stem cells and stem cell niches, aiming at presenting the most forefront issues in stem cell research to be discussed. The authors are encouraged to include any conflicting data and concepts in the past and present to promote current and future investigations in stem cell research.
Dr. Makoto Senoo
Guest Editor
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Keywords
- embryonic stem (ES) cell
- adult stem cell
- somatic stem cell
- induced pluripotent stem cells
- self-renewal
- proliferation
- differentiation
- stem cell niche
- regeneration
- stem cell diseases
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