Molecular and Cellular Biology of Angiogenesis
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 495
Special Issue Editor
Special Issue Information
Dear Colleagues,
Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. This hypoxia-mediated sprouting of new capillaries is crucial for neovascularization, development, and wound healing. It also plays a significant role in pathological conditions such as cancer, diabetic retinopathy, and rheumatoid arthritis. Understanding the molecular and cellular mechanisms underlying angiogenesis is essential for developing targeted therapies for these diseases. There are critical, well-known molecular players in angiogenesis, which include (but are not limited to) vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), angiopoietins (Ang1 and Ang2), and matrix metalloproteinases (MMPs), that have been studied in different vascular conditions. Moreover, there are essential cellular mechanisms in angiogenesis, such as endothelial cell proliferation, differentiation of tip and stalk cells, blood flow regulation/shear stress, and lumen formation. These mechanisms might be associated with hypoxia-inducible factors (HIFs) and integrins, which are angiogenic regulators. By investigating these molecular and cellular mechanisms, scientists aim to develop targeted therapies that can promote or inhibit angiogenesis, depending on the clinical context. Understanding the balance between pro-angiogenic and anti-angiogenic signals is crucial for managing physiological and pathological blood vessel formation.
In light of the above background, this Special Issue titled “Molecular and Cellular Biology of Angiogenesis" will feature studies that enrich the knowledge and explore therapeutical approaches that promote angiogenesis.
Dr. Roberta Marques Lassance-Soares
Guest Editor
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Keywords
- neovascularization
- endothelial proliferation
- vascular growth
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