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Life
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Metabolic Plasticity in Cancer
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Metabolic Plasticity in Cancer

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (26 May 2023) | Viewed by 2189

Special Issue Editors

Dr. Alia D. Ghoneum

E-Mail Website
Guest Editor
Departments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Interests: ovarian cancer tumor microenvironment; cancer cell metabolic reprogramming; ovarian cancer stem cells; PI3K-AKT-mTOR pathway; OXPHOS; lipid metabolism; glycolysis
Dr. Fatma Khalil

E-Mail Website
Guest Editor
Department of Histology, South Valley University, Qena, Egypt
Interests: histology; placental stem cells; microfluidic devices; alginate hydrogel; immunomodulation function
Dr. Heba Mohamed Abdou

E-Mail Website
Guest Editor
Department of Zoology, Faculty of Science, Alexandria University, Alexandria, Egypt
Interests: carbohydrate metabolism; oncogenic signaling; neuro-inflammation; oxidative stress; neurotoxicity; DNA damage
Dr. Hewida H. Fadel

E-Mail Website
Guest Editor
Applied Medical Chemistry, Medical Laboratory Department, Faculty of Applied Health Sciences Technology, Pharos University, Alexandria, Egypt
Interests: cancer chemistry; role of genetic mutation and SNP alterations in cancer; role of epigenetic alterations in severity of COVID-19

Special Issue Information

Dear Colleagues,

It is our privilege to invite you to contribute meaningful articles, including original research and reviews, to our Special Issue: Metabolic Plasticity in Cancer. The field of cancer metabolism is rapidly growing, and discoveries related to the plasticity of cancer cells and their innate ability to swiftly use different sources of energy are becoming increasingly important. We encourage contributions that discuss the dynamic metabolic behavior of cancer cells as well as cancer stem cells and their use of various metabolic pathways, including but not limited to oxidative phosphorylation, fatty acid metabolism, and glycolysis.

Dr. Alia D. Ghoneum
Dr. Fatma Khalil
Dr. Heba Mohamed Abdou
Dr. Hewida H. Fadel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic plasticity
  • cancer stem cells
  • OXPHOS, glycolysis
  • lipid metabolism
  • cancer metabolic reprogramming

Published Papers (1 paper)

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Research

16 pages, 5256 KiB  
Article
Extended Opioid Exposure Modulates the Molecular Metabolism of Clear Cell Renal Cell Carcinoma
by Mamatha Garige, Sarah Poncet, Alexis Norris, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Jacob W. Greenberg, Louis Spencer Krane and Carole Sourbier
Life 2023, 13(5), 1196; https://doi.org/10.3390/life13051196 - 17 May 2023
Cited by 1 | Viewed by 1650
Abstract
Opioids are commonly prescribed for extended periods of time to patients with advanced clear cell renal cell carcinoma to assist with pain management. Because extended opioid exposure has been shown to affect the vasculature and to be immunosuppressive, we investigated how it may [...] Read more.
Opioids are commonly prescribed for extended periods of time to patients with advanced clear cell renal cell carcinoma to assist with pain management. Because extended opioid exposure has been shown to affect the vasculature and to be immunosuppressive, we investigated how it may affect the metabolism and physiology of clear cell renal cell carcinoma. RNA sequencing of a limited number of archived patients’ specimens with extended opioid exposure or non-opioid exposure was performed. Immune infiltration and changes in the microenvironment were evaluated using CIBERSORT. A significant decrease in M1 macrophages and T cells CD4 memory resting immune subsets was observed in opioid-exposed tumors, whereas the changes observed in other immune cells were not statistically significant. Further RNA sequencing data analysis showed that differential expression of KEGG signaling pathways was significant between non-opioid-exposed specimens and opioid-exposed specimens, with a shift from a gene signature consistent with aerobic glycolysis to a gene signature consistent with the TCA cycle, nicotinate metabolism, and the cAMP signaling pathway. Together, these data suggest that extended opioid exposure changes the cellular metabolism and immune homeostasis of ccRCC, which might impact the response to therapy of these patients, especially if the therapy is targeting the microenvironment or metabolism of ccRCC tumors. Full article
(This article belongs to the Special Issue Metabolic Plasticity in Cancer)
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