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Life
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Advances and Applications of Neuroimaging in Brain Disorder
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Advances and Applications of Neuroimaging in Brain Disorder

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Radiobiology and Nuclear Medicine".

Deadline for manuscript submissions: closed (30 March 2026) | Viewed by 5141

Special Issue Editor

Dr. Julio Plata-Bello

E-Mail Website
Guest Editor
Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Interests: neurosurgery; neuroimaging; brain tumors; magnetic resonance imaging

Special Issue Information

Dear Colleagues,

This Special Issue aims to bring together cutting-edge research that harnesses the power of neuroimaging to unravel the complexities of brain disorders, including, but not limited to, Alzheimer's disease, schizophrenia, autism spectrum disorders, traumatic brain injury and mood disorders.

Through this platform, we invite researchers, clinicians and experts in the field to contribute original research articles, reviews and perspectives that shed light on novel neuroimaging methodologies, innovative data analysis techniques and their clinical applications in diagnosing, monitoring and treating brain disorders.

Our goal is to foster an interdisciplinary collaboration and exchange of ideas, driving forward the frontier of neuroimaging research. By enriching our understanding of brain disorders through advanced imaging technologies, we aim to pave the way for a more precise diagnosis, personalized treatment approaches and ultimately, improved outcomes for individuals affected by these conditions.

Join us in this endeavor to push the boundaries of neuroimaging research and make meaningful strides toward unraveling the mysteries of the brain by embarking on this journey together to transform the landscape of neuroscience and clinical practice.

Dr. Julio Plata-Bello
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuroimaging
  • magnetic resonance imaging
  • positron emission tomography
  • near infrared spectroscopy
  • brain
  • dementia
  • schizophrenia
  • depression
  • brain tumors
  • multiple sclerosis
  • autism

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

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17 pages, 1158 KB  
Review
An Update on DOTA-Peptides PET Imaging and Potential Advancements of Radioligand Therapy in Intracranial Meningiomas
by Viviana Benfante, Ignazio Gaspare Vetrano, Muhammad Ali, Pierpaolo Purpura, Cesare Gagliardo, Paola Feraco, Costanza Longo, Tommaso Vincenzo Bartolotta, Patrizia Toia, Oriana Calisto, Albert Comelli, Massimo Midiri and Pierpaolo Alongi
Life 2025, 15(4), 617; https://doi.org/10.3390/life15040617 - 7 Apr 2025
Cited by 3 | Viewed by 4020
Abstract
Meningiomas arise from the meningeal layers covering the central nervous system structures. Although most are benign, meningiomas can still cause neurological morbidity due to the mass effect and compression of the surrounding parenchyma. The prognosis also depends on several factors such as growth [...] Read more.
Meningiomas arise from the meningeal layers covering the central nervous system structures. Although most are benign, meningiomas can still cause neurological morbidity due to the mass effect and compression of the surrounding parenchyma. The prognosis also depends on several factors such as growth pattern or location. Morphological imaging approaches, such as MRI and CT, that emphasize intracranial calcifications, vascular patterns, or invasion of major vessels act as the basis of the diagnosis; PET/CT imaging is a valuable diagnostic tool for assessing somatostatin receptor activity in tumors. It enables the visualization and quantification of somatostatin receptor expression, providing insights into tumor biology, receptor status, and potential therapeutic targets. Aside from radiosurgery and neurosurgical intervention, peptide receptor radionuclide therapy (PRRT) has also shown promising results. Somatostatin receptors 1 and 2 are nearly universally expressed in meningioma tissue. This characteristic is increasingly exploited to identify patients eligible for adjuvant therapy using DOTA-conjugated somatostatin receptor-targeting peptides PET. In the treatment of relapsed/refractory meningiomas, PRRT is increasingly considered a safe and effective therapeutic option. It is often supported by artificial intelligence strategies for dose optimization and side-effect monitoring. The objective of this study is to evaluate the safety and benefits of these strategies based on the latest findings. Full article
(This article belongs to the Special Issue Advances and Applications of Neuroimaging in Brain Disorder)
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12 pages, 790 KB  
Case Report
A Challenging Differential Diagnosis Between Brain Radionecrosis and Recurrent Metastatic Disease, with Temporary Clinical/Radiological Response to Bevacizumab and Later Imaging Suspicious for Oligoprogression
by Ana Maria Rata, Gabriela Rahnea-Nita, Roxana-Andreea Rahnea-Nita, Mihaela Emilia Dumitru, Alexandru Nechifor, Iulia Chiscop, Dan-Andrei Mitrea, Dorel Firescu, Raluca Barzu and Laura-Florentina Rebegea
Life 2026, 16(4), 552; https://doi.org/10.3390/life16040552 - 27 Mar 2026
Viewed by 424
Abstract
Background: Brain radiation necrosis is a side effect of radiotherapy that can occur months, or even years, after the end of treatment. From an anatomical–pathological perspective, it is characterized by avascular damage, demyelination, and necrosis. Methods: We present a case of a patient [...] Read more.
Background: Brain radiation necrosis is a side effect of radiotherapy that can occur months, or even years, after the end of treatment. From an anatomical–pathological perspective, it is characterized by avascular damage, demyelination, and necrosis. Methods: We present a case of a patient with breast cancer cT2N1M0 and multiple brain metastases occurring at 2 years after diagnosis, who was treated with whole-brain radiotherapy (WBRT) and Stereotactic Radiotherapy (SRT) for tumor progression. Dynamic imaging revealed right parietal post-therapeutic changes in aggravation, requiring differential diagnosis between tumor progression (TP) and brain radionecrosis (BRN). Results: Brain radionecrosis and tumor progression are difficult to differentiate due to their similar radiological and clinical characteristics. MRI perfusion plays an important role in differentiating the two entities. Conclusions: Differentiating radiation necrosis from a recurrent tumor is crucial for appropriate treatment. Medical management includes corticosteroids as first-line treatment, after which bevacizumab is administered as secondary therapy. Full article
(This article belongs to the Special Issue Advances and Applications of Neuroimaging in Brain Disorder)
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