Personalized Medicine for Rheumatic Disorders

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: closed (15 September 2022) | Viewed by 4910

Special Issue Editor


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Guest Editor
School of Medicine and Dentistry, University of Rochester Medical Center, 601 Elmwood Ave, Box 695, Rochester, NY 14642, USA
Interests: rheumatoid arthritis; psoriatic arthritis; autoimmune bone diseases

Special Issue Information

Dear Colleagues,

Rheumatic disorders affect many people worldwide. People with rheumatic disorders suffer from chronic pain and functional impairment, and face significant health challenges as well as decreased quality of life. Currently, rheumatic diseases are one of the most common causes of worldwide disability.

In recent decades, significant technological advances resulting in an increased understanding of the critical pathological molecular mechanism of many rheumatic diseases have revolutionized their prognosis and outcome. Such advances include the concepts of tight control, treat-to-target, the development of biologics, and targeted therapies. However, rheumatic disorders are clinically heterogeneous. Each condition further has different subtypes. These disease heterogeneities pose significant challenges to effectively selecting the most suitable treatment strategies among the available treatment options.

Genetics studies, along with the recently developed cutting-edge molecular techniques, advanced imaging modalities, and other novel approaches, are changing the landscape of autoimmune diseases from clinical and serological to biologic and molecular characterization. The ongoing and future molecular and clinical studies assisted by multi-omics approaches will improve our understanding of involved molecular mechanisms active in a specific subset of patients suffering from any particular type of rheumatic disease. These insights will further enable us to select the optimal treatment for each patient based on clinical characteristics in the coming days. 

This Special Issue invites reviews, articles, communications, and protocols about new findings on the epidemiology, pathogenesis, diagnosis, and treatment of rheumatic diseases.

Dr. Ananta Paine
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rheumatic disease
  • arthritis
  • personalized medicine
  • omics
  • pathogenesis
  • immunity
  • targeted therapy

Published Papers (1 paper)

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Review

23 pages, 422 KiB  
Review
Pharmacogenomics of Monoclonal Antibodies for the Treatment of Rheumatoid Arthritis
by Sung Ho Lim, Khangyoo Kim and Chang-Ik Choi
J. Pers. Med. 2022, 12(8), 1265; https://doi.org/10.3390/jpm12081265 - 31 Jul 2022
Cited by 8 | Viewed by 4605
Abstract
Precision medicine refers to a highly individualized and personalized approach to patient care. Pharmacogenomics is the study of how an individual’s genomic profile affects their drug response, enabling stable and effective drug selection, minimizing side effects, and maximizing therapeutic efficacy. Rheumatoid arthritis (RA) [...] Read more.
Precision medicine refers to a highly individualized and personalized approach to patient care. Pharmacogenomics is the study of how an individual’s genomic profile affects their drug response, enabling stable and effective drug selection, minimizing side effects, and maximizing therapeutic efficacy. Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in the joints. It mainly starts in peripheral joints, such as the hands and feet, and progresses to large joints, which causes joint deformation and bone damage due to inflammation of the synovial membrane. Here, we review various pharmacogenetic studies investigating the association between clinical response to monoclonal antibody therapy and their target genetic polymorphisms. Numerous papers have reported that some single nucleotide polymorphisms (SNPs) are related to the therapeutic response of several monoclonal antibody drugs including adalimumab, infliximab, rituximab, and tocilizumab, which target tumor necrosis factor (TNF), CD20 of B-cells, and interleukin (IL)-6. Additionally, there are some pharmacogenomic studies reporting on the association between the clinical response of monoclonal antibodies having various mechanisms, such as IL-1, IL-17, IL-23, granulocyte-macrophage colony-stimulating factor (GM-CSF) and the receptor activator of nuclear factor-kappa B (RANK) inhibition. Biological therapies are currently prescribed on a “trial and error” basis for RA patients. If appropriate drug treatment is not started early, joints may deform, and long-term treatment outcomes may worsen. Pharmacogenomic approaches that predict therapeutic responses for RA patients have the potential to significantly improve patient quality of life and reduce treatment costs. Full article
(This article belongs to the Special Issue Personalized Medicine for Rheumatic Disorders)
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