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Personalized Medicine in Endometriosis
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Personalized Medicine in Endometriosis

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 10 December 2026 | Viewed by 3489

Special Issue Editor

Dr. Christine Bekos

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Medical University of Vienna, 1090 Vienna, Austria
Interests: endometriosis; fatigue; laparoscopic surgery; robotic surgery

Special Issue Information

Dear Colleagues,

Personalized medicine is set to transform endometriosis management through individualized care tailored to genetic, environmental, and lifestyle factors. This Special Issue aims to compile research advancing clinical practice by customizing medication, surgical approaches, and behavioral advice to meet patient needs.

We invite submissions of original research articles and review papers on metagenomics and epigenetics, particularly on how microbiome and epigenetic changes affect treatment options and outcomes. Pharmacogenomics, which adapts drug regimens to genetic profiles for better efficacy and safety, is another area of interest.

We seek research on personalized therapies for endometriosis, focusing on nonspecific complaints such as fatigue, mood disorders, gastrointestinal issues, and stomach complaints. We also welcome studies on the gut microbiome's role in pain perception and symptom management via microbiota manipulation.

The importance of screening and preventive care, along with the development of innovative diagnostic tools and techniques, completes our focus areas.

We look forward to your contributions.

Dr. Christine Bekos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • epigenetics
  • fatigue
  • laparoscopic surgery
  • lifestyle changes
  • endometriosis

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

13 pages, 625 KB  
Article
Safety and Reproductive Outcomes of Minimally Invasive Nerve-Sparing Surgery for Deep Endometriosis in Infertile Women: A One-Year Follow-Up Study
by Bruna Rafaela Oliveira, Claudio Peixoto Crispi Jr., Fabio Bastos Russomano, Fernando Maia Peixoto Filho, Nilton de Nadai Filho and Marlon de Freitas Fonseca
J. Pers. Med. 2026, 16(3), 166; https://doi.org/10.3390/jpm16030166 - 17 Mar 2026
Viewed by 554
Abstract
Background/Objectives: Deep endometriosis is a chronic inflammatory disease that significantly affects fertility. The objective was to evaluate the magnitude of the effect of minimally invasive nerve-sparing complete excision of endometriosis on natural conception rate in women with documented infertility. Methods: This [...] Read more.
Background/Objectives: Deep endometriosis is a chronic inflammatory disease that significantly affects fertility. The objective was to evaluate the magnitude of the effect of minimally invasive nerve-sparing complete excision of endometriosis on natural conception rate in women with documented infertility. Methods: This pre-planned interdisciplinary retrospective observational study included 45 patients who wished to conceive naturally (spontaneous pregnancy) and were followed for 12 months after surgery. Results: The spontaneous conception rate was 33.3% (95% CI: 20.0–46.7) and the mean time to conception was 6.7 months. Age, body mass index, and history of infertility showed no significant differences between the success and failure spontaneous pregnancy groups, but annual income was positively associated with reproductive success (p = 0.022). None of the procedures needed to be converted to open surgery, required colostomy/ileostomy, blood transfusion or abdominal drains. No cases of urinary retention were observed across different levels of nerve preservation. In addition, the absence of serious surgical complications (Clavien–Dindo III/IV) supports the safety of this intervention for infertile patients. Conclusions: The absence of serious surgical complications in this cohort supports the concept that minimally invasive nerve-sparing complete excision of endometriosis is a safe intervention when performed by an experienced team. The results underscore the importance of exploring socioeconomic-related factors through an individualized assessment of patients who wish to conceive naturally after minimally invasive nerve-sparing surgery. Future studies focusing on personalized management of endometriosis should attempt to identify socioeconomic-related covariates that influence natural conception. Full article
(This article belongs to the Special Issue Personalized Medicine in Endometriosis)
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14 pages, 298 KB  
Article
The Role of Chronic Endometritis in Endometriosis: A Personalized Diagnostic Tool?
by María Luna Arana, Augusto Pereira Sánchez, Gema Vaquero Argüello, Eva Tejerina González, Milagros Alonso-Iniesta and Tirso Pérez Medina
J. Pers. Med. 2026, 16(2), 73; https://doi.org/10.3390/jpm16020073 - 31 Jan 2026
Cited by 1 | Viewed by 948
Abstract
(1) Background: Endometriosis and chronic endometritis (CE) are pathologies that are positively correlated and have similar paracrine and immunological alterations. This leads us to wonder whether their interrelationship plays a role in the etiopathogenesis or progression of endometriosis. The purpose of this [...] Read more.
(1) Background: Endometriosis and chronic endometritis (CE) are pathologies that are positively correlated and have similar paracrine and immunological alterations. This leads us to wonder whether their interrelationship plays a role in the etiopathogenesis or progression of endometriosis. The purpose of this study is to evaluate whether patients with endometriosis and CE have a more advanced stage of the disease, higher rates of pain, a poorer response to treatment, and a greater association with other pathologies compared to women with endometriosis without CE. (2) Methods: This is a cross-sectional pilot design study of 37 women with endometriosis who underwent endometrial aspiration for the diagnosis of CE and were followed up at the Puerta de Hierro Hospital. (3) Results: All patients with CE in this study had adenomyosis (p = 0.004). There was a relatively homogeneous distribution of CE in the different endometriosis phenotypes. The group of patients with endometriosis and CE indicated higher rates of pain during ovulation and less pain during defecation and sexual intercourse. (4) Conclusions: A high prevalence of CE was observed in patients with endometriosis, as well as a trend suggesting a relationship between CE and adenomyosis that should be studied. The following article attempts to reflect a link found between endometriosis and chronic endometritis, which would be important when prescribing personalized medicine, as it forces us to look for a specific disease in a specific patient profile. Full article
(This article belongs to the Special Issue Personalized Medicine in Endometriosis)
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15 pages, 728 KB  
Article
The Fibrinogen-to-Albumin Ratio in Endometriosis: A Step Toward Personalized Non-Invasive Diagnostics
by Lejla Samson, Theresa Mally, Chiara Paternostro, Alfie Bill, Lorenz Kuessel and Christine Bekos
J. Pers. Med. 2026, 16(1), 20; https://doi.org/10.3390/jpm16010020 - 4 Jan 2026
Viewed by 897
Abstract
Background/Objectives: Endometriosis is a chronic inflammatory disease affecting up to 10–15% of women of reproductive age and is frequently associated with pelvic pain and infertility. Non-invasive biomarkers remain insufficient for accurate diagnosis, often necessitating laparoscopic confirmation. The fibrinogen-to-albumin ratio (FAR), a composite marker [...] Read more.
Background/Objectives: Endometriosis is a chronic inflammatory disease affecting up to 10–15% of women of reproductive age and is frequently associated with pelvic pain and infertility. Non-invasive biomarkers remain insufficient for accurate diagnosis, often necessitating laparoscopic confirmation. The fibrinogen-to-albumin ratio (FAR), a composite marker of systemic inflammation, has been proposed in both oncological and cardiovascular disease but has not yet been evaluated in endometriosis. Methods: We conducted a retrospective monocentric study including 390 women who underwent laparoscopy between January 2015 and December 2021 at the Medical University of Vienna. Of these, 218 had histologically confirmed endometriosis and 172 had benign ovarian cysts. Preoperative laboratory data was collected, and FAR was calculated. Group comparisons were performed using the Mann–Whitney U test. ANOVA was used to compare FAR across revised American Society for Reproductive Medicine (rASRM) stages, and Spearman’s rank correlation assessed associations with disease severity. Subgroup analyses were performed for adenomyosis and deep infiltrating endometriosis (DIE). Results: FAR was significantly higher in women with endometriosis than in controls (median 0.0679, IQR 0.0588–0.0778 vs. 0.0641, IQR 0.0559–0.716; p = 0.0035). Across rASRM stages I–IV, FAR values were comparable (means 0.0691–0.0709) and did not differ significantly (p = 0.822, ANOVA). Spearman’s correlation confirmed no significant association with disease stage (ρ = 0.085, p = 0.24). In exploratory analyses, women with adenomyosis (n = 35) showed a non-significant trend toward a higher median FAR compared to those without adenomyosis (0.0707 vs. 0.0669; p = 0.073, one-sided). No difference in FAR was observed between women with deep infiltrating endometriosis (DIE; n = 144) and those without (0.0680 vs. 0.0672; p = 0.389, one-sided). Conclusions: Although FAR alone cannot replace surgical confirmation, the difference observed between the groups may reflect the systemic inflammatory aspect of endometriosis and should be investigated further in future studies. Given its accessibility and cost-effectiveness, FAR may support the development of non-invasive, personalized diagnostic approaches when combined with other clinical and molecular markers. Full article
(This article belongs to the Special Issue Personalized Medicine in Endometriosis)
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