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Special Issues
Treatment and Management of Sleep Apnea
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Treatment and Management of Sleep Apnea

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2083

Special Issue Editor

Dr. Min Young Seo

E-Mail Website
Guest Editor
Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Ansan 15355, Republic of Korea
Interests: obstructive sleep apnea; endoscopic skull base surgery; olfaction; upper airway infection; chronic rhinosinusitis; allergic rhinitis

Special Issue Information

Dear Colleagues,

This Special Issue aims to gather a diverse range of research articles and reviews focusing on innovative therapies, emerging technologies, and novel approaches to OSA management. Key topics include novel therapeutic interventions, advancements in continuous positive airway pressure (CPAP) therapy, surgical outcomes, pharmacological approaches, technological innovations, and personalized medicine in OSA treatment. Manuscripts adhering to standard guidelines are welcome, encompassing original research, systematic reviews, meta-analyses, and clinical studies. Submission details, including deadlines and guidelines, can be found on our online submission platform. We believe that this Special Issue will contribute significantly to the OSA research landscape, fostering collaboration and knowledge exchange among researchers.

Dr. Min Young Seo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obstructive sleep apnea
  • positive airway pressure treatment
  • upper airway surgery
  • pharmacological treatment
  • behavioral therapy
  • oral appliance

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

21 pages, 5859 KB  
Review
Pediatric OSA—Spectrum of the Disease and Opportunities for Personalized Interventions
by Hui-Leng Tan, Athanasios Kaditis and David Gozal
J. Pers. Med. 2026, 16(5), 259; https://doi.org/10.3390/jpm16050259 - 12 May 2026
Abstract
Pediatric obstructive sleep-disordered breathing encompasses a wide spectrum of diagnostic clusters, including primary snoring, upper airway resistance syndrome, mild, moderate, and severe obstructive sleep apnea, and obstructive hypoventilation. Even within these classifications, the symptomatic presentation involves a large array of variations, reflecting a [...] Read more.
Pediatric obstructive sleep-disordered breathing encompasses a wide spectrum of diagnostic clusters, including primary snoring, upper airway resistance syndrome, mild, moderate, and severe obstructive sleep apnea, and obstructive hypoventilation. Even within these classifications, the symptomatic presentation involves a large array of variations, reflecting a wide phenotypic spectrum. Here, we aim to summarize current diagnostic criteria and explore the spectrum of disease, particularly highlighting the phenotypic variation and its potential relevance to therapeutic decisions and overall outcomes. It has become apparent that polysomnographic (PSG) indices do not correlate well with associated morbidities, even though one-night in-lab PSGs are considered the diagnostic gold standard. Novel approaches, including exploration of plasma and urine biomarkers and data-mining the physiological information embedded within the PSG, may enable the extraction of phenotypic information that can then be interpreted in conjunction with clinical data, including history, physical examination findings, risk factors, and associated disease morbidity, so that an individualized treatment plan can be optimally delineated. Full article
(This article belongs to the Special Issue Treatment and Management of Sleep Apnea)
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Graphical abstract

18 pages, 517 KB  
Review
Advances in Non-CPAP Management of Obstructive Sleep Apnea: Spotlight on Pharmacological Therapies
by Matteo Siciliano, Martina de Scisciolo, Antonio Fratini, Costanza Sottani, Federico Giordani and Valerio Brunetti
J. Pers. Med. 2026, 16(2), 105; https://doi.org/10.3390/jpm16020105 - 10 Feb 2026
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Abstract
Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder associated with significant cardiometabolic morbidity, impaired neurocognitive functioning, daytime sleepiness, and reduced quality of life. Although continuous positive airway pressure (CPAP) therapy remains the cornerstone of treatment for moderate-to-severe OSA, long-term adherence [...] Read more.
Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder associated with significant cardiometabolic morbidity, impaired neurocognitive functioning, daytime sleepiness, and reduced quality of life. Although continuous positive airway pressure (CPAP) therapy remains the cornerstone of treatment for moderate-to-severe OSA, long-term adherence is frequently suboptimal, and a substantial proportion of patients experience residual symptoms despite adequate therapy. These limitations have driven increasing interest in non-CPAP treatment strategies and, more recently, in pharmacological approaches tailored to specific OSA pathophysiological mechanisms. This narrative review provides an updated overview of non-CPAP therapies for OSA, including oral appliances, surgical interventions, positional therapy, hypoglossal nerve stimulation, and behavioral strategies, with a particular focus on emerging and established pharmacological treatment and their role in endotype/phenotype-guided management of OSA. Overall, the expanding pharmacological landscape of OSA reflects a paradigm shift toward personalized, multimodal management. Integrating non-CPAP and pharmacological therapies with patient-specific pathophysiology may improve symptom control, adherence, and long-term outcomes in OSA. Full article
(This article belongs to the Special Issue Treatment and Management of Sleep Apnea)
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