Journal of Personalized Medicine

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Special Issue Editor

Prof. Dr. Yan Zheng

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Guest Editor

1. Second Clinical School of Xi'an Jiaotong University, Xi'an City, Shaanxi Province, China
2. Department of Dermatology, the Second Affiliated Hospital of Xian Jiaotong University, Xi'an City, Shaanxi Province, China
Interests: psoriasis; skin tumors; pathogenesis; treatment

Special Issue Information

Dear Colleagues,

Psoriasis and skin tumors, such as cutaneous squamous cell carcinoma and melanoma, are abnormal skin diseases which bring a great burden to some patients and society. However, the pathogenesis of these diseases is not clear and there is a need for more research on the pathogenesis and new therapies. This special issue of the Journal of Personalized Medicine aims to show some of the latest findings in the field of Psoriasis and skin tumors. Studies include those that explore the pathogenesis or the treatment of Psoriasis and skin tumors using basic science, clinical and other approaches. We welcome your input with either original research articles or reviews. The scientific advances in the field of Psoriasis and skin tumors will continue to pave the path towards personalized treatment for patients.

Prof. Dr. Yan Zheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

psoriasis
skin tumors
cutaneous squamous cell carcinoma
melanoma
pathogenesis
biomarkers
treatment

Published Papers (2 papers)

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Research

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9 pages, 729 KiB

Open AccessArticle

Multisystem Langerhans Cell Histiocytosis in Younger Infants First Presenting in Skin: A Case Series

by Dan Han, Fei Li, Wahid H. Yahya, Rui Ge, Yan Zhao, Bei Liu, Yan Zhou and Zhuoyu Wen

J. Pers. Med. 2022, 12(7), 1024; https://doi.org/10.3390/jpm12071024 - 22 Jun 2022

Cited by 3 | Viewed by 2109

Abstract

Objectives—To investigate the clinical characteristics, managements, outcome, and evaluate the risk factors of Multisystem (MS) Langerhans Cell Histiocytosis (LCH) with diverse skin lesions as the first sign in four young infants. Methods—Their clinical features, disease progression, therapy, and outcomes were reviewed and analyzed retrospectively. Results—The average onset age of skin lesions was about 2 months. Cases 1 and 2 had risk organs involved (RO+) and a lack of bone lesions, and progression could not be reversed by systemic chemotherapy. They both died eventually. Cases 3 and 4 (RO–) had bone involvement and were given systemic chemotherapy for a prolonged duration. Unluckily, Case 3 had a recurrence 2 years later, while Case 4’s recurrence happened nearly one year later, and diabetes insipidus one and a half years later. They both survived and are still in remission. Conclusion—MS-LCH infants with a low age of the first presentation in the skin are prone to dissemination, while RO+ is associated with high mortality. In addition, bone involvement may be a protective factor. Immunohistochemical examination of skin tissue facilitates correct early diagnosis, and adequate follow-up is necessary. Full article

(This article belongs to the Special Issue The Pathogenesis and Treatment of Psoriasis and Skin Tumors)

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Review

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10 pages, 895 KiB

Open AccessReview

Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis

by Jinjing Jia, Yuqian Wang, Xiumei Mo and Dacan Chen

J. Pers. Med. 2022, 12(6), 978; https://doi.org/10.3390/jpm12060978 - 16 Jun 2022

Cited by 3 | Viewed by 2090

Abstract

Psoriasis and skin tumors (such as basal cell carcinoma, squamous cell carcinoma, and melanoma) are chronic diseases that endanger physical and mental health, and yet the causes are largely unknown and treatment options limited. The development of targeted drugs requires a better understanding of the exact pathogenesis of these diseases, and Yes-associated protein (YAP), a member of the Hippo signaling pathway, is believed to play an important role. Psoriasis and skin tumors are characterized by excessive cell proliferation, abnormal differentiation, vasodilation, and proliferation. Here, we review the literature related to YAP-associated disease mechanisms and discuss the latest research. YAP regulates cell apoptosis, proliferation, and differentiation; inhibits cell density and intercellular contacts and angiogenesis; and maintains the three-dimensional structure of the skin. These mechanisms may be associated with the occurrence and development of psoriasis and skin tumors. The results of recent studies have shown that YAP expression is increased in psoriasis and skin tumors. High expression of YAP in psoriasis and skin tumors may indicate its positive functions in skin inflammation and malignancies and may play an important role in disease pathogenesis. The study of new drugs targeting YAP can provide novel approaches for the treatment of skin diseases. Full article

(This article belongs to the Special Issue The Pathogenesis and Treatment of Psoriasis and Skin Tumors)

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