Journal of Personalized Medicine

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Special Issue Editors

Dr. Yongchu Pan

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Guest Editor

Jiangsu Provincial Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China
Interests: craniofacial developmental anomalies; genetics; mechanism

Dr. Dong Han

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Guest Editor

Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China
Interests: tooth development; tooth agenesis; tooth regeneration
Special Issues, Collections and Topics in MDPI journals

Dr. Miao He

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Guest Editor

Department of Pediatric Dentistry, School of Stomatology, Wuhan University, Wuhan 430072, China
Interests: oral and craniofacial genetics and development

Special Issue Information

Dear Colleagues,

The Journal of Personalized Medicine is currently preparing a Special Issue entitled Genetics, Personalized Diagnosis and Treatment of Oral Disease. Oral Disease is mainly concerned with the study of oral organs (teeth, alveolar bone, lips, cheeks, tongue, palate, pharynx, etc.), facial soft tissue, maxillofacial complex bone structure (maxilla, mandible, etc.), pulpitis, periodontitis, repair of tooth defects, orthodontics of malocclusion, etc. The aim of this series is to provide up-to-date information on the new genetic approaches, personalized diagnosis and therapeutic strategies of oral disease. We are pleased to invite you to contribute a paper on ‘Genetics, Personalized Diagnosis and Treatment of Oral Disease’.

The formatting guidelines and submission instructions can be found on our author guidelines page.

We would be grateful to include your contribution in this Special Issue. Your manuscript will be sent for regular peer review, and a decision will be made for each paper. If you have any other questions, please do not hesitate to contact me.

We look forward to hearing from you.

Best regards,

Dr. Yongchu Pan
Dr. Dong Han
Dr. Miao He
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

oral diseases
molecular genetics
personalized diagnosis
therapeutic strategies
repair of tooth defects
clinical application

Published Papers (2 papers)

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Research

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11 pages, 930 KiB

Open AccessArticle

Relationship between the TGFBR1 Gene and Molar Incisor Hypomineralization

by Laura Georgina-Pérez, David Ribas-Pérez, Alexandra Dehesa-Santos and Asunción Mendoza-Mendoza

J. Pers. Med. 2023, 13(5), 777; https://doi.org/10.3390/jpm13050777 - 30 Apr 2023

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Abstract

Background: Molar Incisor Hypomineralization Syndrome (MIH) is a problem of increasing incidence that represents a new challenge in the dental treatment of many of the children we see in our dental offices. Understanding the etiology of this syndrome (still unknown) will help us to prevent the appearance of this process. Lately a certain genetic relationship has been suggested in the syndrome. The aim of the present study was to explore the relationship between activation of the TGFBR1 gene and the development of MIH, as recent studies suggest that there may be an association in this regard. Materials and Methods: The study sample consisted of 50 children between 6–17 years of age with MIH, each with at least one parent and a sibling with or without MIH, and a group control of 100 children without MIH. The condition of the permanent molars and incisors was evaluated and recorded based on the criteria of Mathu-Muju and Wright. Saliva samples were collected after washing and rinsing of the oral cavity. Genotyping was performed with the saliva samples for the selection of a target polymorphism of the studied gene (TGFBR1). Results: The mean age was 9.7 years (SD 2.36). Of the 50 children with MIH, 56% were boys and 44% girls. The degree of MIH was predominantly severe (58%), with moderate and mild involvement in 22% and 20% of the cases, respectively, according to the classification of Mathu-Muju. The allelic frequencies were seen to behave as expected. The logistic regression analysis aimed to relate each polymorphism to the presence or absence of the factors. These results were inconclusive, with no evidence suggesting an alteration of the TGFBR1 gene to be related to the appearance of MIH. Conclusions: Within the limitations posed by a study of these characteristics, it can be affirmed that no relationship has been found between the TGFBR1 gene and the appearance of molar incisor hypomineralization. Full article

(This article belongs to the Special Issue Genetics, Personalized Diagnosis and Treatment of Oral Disease)

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Other

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16 pages, 485 KiB

Open AccessSystematic Review

Neuroendocrine Influencers and Associated Factors That Shape Jaw Movement and Growth in Temporomandibular Joint Disorder Management: A Systematic Review of Clinical and Radiographic Evidence

by Taseef Hasan Farook and James Dudley

J. Pers. Med. 2023, 13(5), 840; https://doi.org/10.3390/jpm13050840 - 16 May 2023

Cited by 3 | Viewed by 1528

Abstract

Objective. To investigate the influence of endogenous and exogenous neuroendocrine analogues on the range and motion of jaw movement, mandibular growth, and factors affecting condylar guidance in patients with temporomandibular joint disorders using clinical assessment and radiographic imaging. Material and Methods. Eligible articles were extracted from eleven databases in early 2023 and screened following PRISMA protocols. Certainty of evidence and potential biases were assessed using the GRADE approach. Results. Nineteen articles were screened, with four deemed to be of high quality, eight of moderate quality, and the remaining seven of low to very low quality. Corticosteroids improve maximal incisal opening but not TMJ disorder symptoms. Higher doses worsen jaw movement and cause osseous deformity. Growth hormone affects occlusal development, and delayed treatment affects arch width. Sex hormone correlation with TMJ disorder is complex, with some studies showing a correlation between menstrual cycle phases and pain/limited mobility. Conclusions. The evaluation of neuroendocrine influencers in relation to jaw movement in patients with temporomandibular joint disorders involves the complex interplay of potentially confounding factors that each require careful consideration to ensure accurate diagnoses and evaluations. Full article

(This article belongs to the Special Issue Genetics, Personalized Diagnosis and Treatment of Oral Disease)

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