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JPM
Special Issues
Novel Challenges and Advances in Thoracic Surgery
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Novel Challenges and Advances in Thoracic Surgery

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (10 February 2025) | Viewed by 554

Special Issue Editor

Dr. Antonio Mazzella

E-Mail Website
Guest Editor
Division of Thoracic Oncology, European Institute of Oncology (IEO), Milano, Italy
Interests: minimally invasive thoracic surgery; robotic surgery; thoracic surgery; thoracic oncology; lung cancer; thoracic neoplasms
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues

We are living in a new era in which progress has involved all branches of oncology and surgery, overturning some of the established cornerstones over the decades.

We aim to publish articles describing novel challenges and advances in thoracic surgery, from minimally invasive and robotic surgery for early or locally advanced lung cancer to more complex cases, including post-neoadjuvant (immuno or biological therapy) surgery. In this Special Issue, we aim to explore electromagnetic navigation bronchoscopy, 3D techniques, and medically innovative treatments.

Thanks to the significant advancement of technology (both in surgery and oncology), the advent of artificial intelligence, and the innovation of new drugs in the treatment of lung cancer, in the last 15 days we witnessed an important improvement in the medical care of patients affected by lung cancer, with extraordinary oncological and medical results.

Investigating all new therapeutic and surgical possibilities in the field of thoracic oncology. Evaluating the potential advantages of minimally invasive surgery, target therapy, and immunotherapy in the treatment of early and advanced lung cancer.

We encourage the submission of manuscripts that describe all novel challenges and advances in the treatment of lung cancer, both surgical and medical.

Dr. Antonio Mazzella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • thoracic surgery
  • robotic surgery
  • minimally invasive surgery
  • target therapy
  • immunotherapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

10 pages, 2831 KiB  
Article
The Actual Role of CPET in Predicting Postoperative Morbidity and Mortality of Patients Undergoing Pneumonectomy
by Antonio Mazzella, Riccardo Orlandi, Patrick Maisonneuve, Clarissa Uslenghi, Matteo Chiari, Monica Casiraghi, Luca Bertolaccini, Giovanni Caffarena and Lorenzo Spaggiari
J. Pers. Med. 2025, 15(4), 136; https://doi.org/10.3390/jpm15040136 - 31 Mar 2025
Viewed by 267
Abstract
This study aims to determine whether maximal oxygen consumption (VO2max) or predicted postoperative (ppo)-VO2max could still reliably predict postoperative complications and deaths in lung cancer patients undergoing pneumonectomy and which values could be more reliably considered as the optimal threshold. Methods: We [...] Read more.
This study aims to determine whether maximal oxygen consumption (VO2max) or predicted postoperative (ppo)-VO2max could still reliably predict postoperative complications and deaths in lung cancer patients undergoing pneumonectomy and which values could be more reliably considered as the optimal threshold. Methods: We retrospectively collected data of consecutive patients undergoing pneumonectomy for primary lung cancer at the European Oncological Institute (April 2019–April 2023). Routine preoperative assessment included cardiopulmonary exercise testing (CPET) and a lung perfusion scan. We evaluated the morbidity and mortality rates; associations between morbidity, mortality, VO2max, and ppoVO2max values were investigated through ANOVA or Fisher’s exact test as appropriate. Receiver operating characteristic (ROC) curves were applied to further explore the relation between VO2max, ppoVO2max values, and 90-day mortality. Results: The cardiopulmonary morbidity rate was 32.2%; the 30-day and 90-day mortality rates were 2.2% and 6.7%. The PpoVO2max values were significantly lower in patients experiencing cardiopulmonary complications or deaths compared to the whole cohort, whereas VO2max, though showing a trend towards lower values, did not reach statistical significance. A VO2max value threshold of 15 mL/kg/min correlated significantly with 90-day mortality, while a ppoVO2max cut-off of 10 mL/kg/min was significantly associated with cardiopulmonary complications and 30-day and 90-day mortality rates. ROC curve analysis revealed ppoVO2max as a better predictor of 90-day mortality compared to VO2max. Conclusions: CPET and a lung perfusion scan are two key elements for the preoperative evaluation of patients undergoing pneumonectomy, since it provides a holistic assessment of cardiopulmonary functionality. We recommend the routine calculation of ppoVO2max, particularly when adopting a 10 mL/kg/min threshold. Full article
(This article belongs to the Special Issue Novel Challenges and Advances in Thoracic Surgery)
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