Advancing Anesthesia and Pain Control Through Precision Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy in Clinical Medicine".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1453

Special Issue Editors


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Guest Editor
Department of Anesthesia and Intensive Care Medicine, Gruppo Ospedaliero San Donato, Policlinico Ponte San Pietro, Ponte San Pietro, Italy
Interests: regional anesthesia; pain management; perioperative anesthesia; intensive care; acute postoperative pain

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Guest Editor
Department of Anesthesia and Intensive Care, ASST Nord Milano, Ospedale Bassini, 20097 Cinisello Balsamo, Italy
Interests: intensive care medicine; critical illness; anesthesiology; pain management; critical care; respiratory failure and mechanical ventilation, nutritional support in ICU; lung imaging; muscle ultrasound; sepsi and new biomarkers

Special Issue Information

Dear Colleagues,

Precision medicine is transforming healthcare by enabling personalized and targeted treatments. Its advances have played a key role in enhancing anesthesia and pain management, as tailoring interventions to individual characteristics can significantly improve outcomes and reduce risks. Recent innovations—from cutting-edge anesthesia techniques to novel approaches in pain control—are reshaping clinical practice for both acute and chronic pain, significantly improving patient care.

As the field evolves, it presents new challenges and exciting opportunities to further improve patient outcomes.

This Special Issue aims to investigate advances in anesthetic techniques and pain management strategies across diverse clinical settings, as well as the implementation of personalized, patient-centered approaches. A particular focus will be on how precision medicine can be integrated into these areas to optimize patient care and improve treatment outcomes.

We encourage contributions that explore innovative techniques, therapies, and evidence-based practices, ranging from basic science to clinical trials. We are also interested in practical models for integrating pain services into clinical practice and developing multidisciplinary frameworks to improve patient safety and outcomes.

We welcome original research articles, reviews, case series, and perspective papers from anesthesiologists, pain specialists, palliative care providers, and allied professionals involved in the complex care of patients experiencing acute or chronic pain.

Our goal is to provide a comprehensive platform for the latest research, innovations, and emerging trends in anesthesia and pain control.

We are seeking the following types of manuscripts:

  • Original Research Articles: Investigating novel techniques, interventions, or therapies in anesthesia and pain control.
  • Review articles: Offering comprehensive analyses of current trends, challenges, or breakthroughs in the field.
  • Guidelines, Tutorials, and Best Practices: Providing expert recommendations on improving anesthesia and pain management practices.
  • Other Contributions: Presenting unique clinical scenarios, innovative treatment strategies, insightful commentaries and reflections, or future directions in anesthesiology and pain management.

We encourage you to contribute by submitting your manuscript. Your insights and research will help push the boundaries of knowledge in both basic science and clinical applications, offering patient-centered solutions to clinical challenges in pain management and anesthesia.

Dr. Francesco Vetrone
Dr. Angelo M. Pezzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anesthesia
  • pain control
  • clinical practice
  • innovative techniques
  • evidence-based practice
  • pharmacology
  • personalized medicine
  • perioperative analgesia
  • chronic pain
  • acute pain

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Published Papers (1 paper)

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Review

17 pages, 571 KB  
Review
Personalized Parenteral Nutrition in Critically Ill Patients Undergoing Continuous Renal Replacement Therapy: A Comprehensive Framework for Clinical Practice
by Nicola Sinatra, Antonino Maniaci, Giuseppe Cuttone, Tarek Senussi Testa, Simona Tutino, Daniele Salvatore Paternò, Alessandro Girombelli, Giovanni Ippati, Giorgia Caputo, Massimiliano Sorbello and Luigi La Via
J. Pers. Med. 2025, 15(11), 545; https://doi.org/10.3390/jpm15110545 - 9 Nov 2025
Viewed by 1268
Abstract
Critically ill patients receiving continuous renal replacement therapy (CRRT) face distinct nutritional challenges requiring specialized parenteral nutrition (PN) strategies. This review synthesizes current evidence with clinical expertise to provide a comprehensive nutritional framework for this population. Key findings reveal that CRRT significantly impacts [...] Read more.
Critically ill patients receiving continuous renal replacement therapy (CRRT) face distinct nutritional challenges requiring specialized parenteral nutrition (PN) strategies. This review synthesizes current evidence with clinical expertise to provide a comprehensive nutritional framework for this population. Key findings reveal that CRRT significantly impacts nutrient homeostasis through daily losses of amino acids (14–22 g), water-soluble vitamins, and trace elements via the extracorporeal circuit. Results from observational studies demonstrate that higher protein targets (1.8–2.5 g/kg/day) are necessary to achieve positive nitrogen balance, while energy prescriptions must subtract “hidden” calories from citrate anticoagulation (3–4 kcal/mmol) and propofol (1.1 kcal/mL). Clinical outcome data, though primarily observational, indicate that achieving nutritional adequacy correlates with reduced ICU stays (average reduction 2.1–3.4 days), shorter mechanical ventilation duration, and improved functional recovery. Evidence supports that early PN prescription when indicated, coupled with systematic consideration of therapy modality, extracorporeal losses, oral intake capacity, and mobilization status, optimizes nutritional support. We conclude that successful implementation requires: (1) dynamic adjustment based on CRRT parameters, (2) integration with enteral nutrition when feasible, (3) regular metabolic monitoring, (4) multidisciplinary collaboration, and (5) structured protocols. Future research using point-of-care analysis and AI-driven support systems is needed to establish evidence-based guidelines in this specialized population. Full article
(This article belongs to the Special Issue Advancing Anesthesia and Pain Control Through Precision Medicine)
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