Advancing Personalized Medicine: Targeting Oxidative Stress in Neurodegenerative Diseases
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: 25 December 2025 | Viewed by 743
Special Issue Editor
2. European Brain Research Institute-Fondazione Rita Levi-Montalcini, Rome, Italy
Interests: neurodegeneration; cell death; neuroprotection; neuronal death; intracellular signaling
Special Issue Information
Dear Colleagues,
The rising prevalence of neurodegenerative disorders, significantly influenced by epigenetic factors, underscores the urgent need for personalized medicine approaches that integrate innovative technologies to enhance clinical treatment efficacy. Oxidative stress, which is characterized by an imbalance between reactive oxygen and nitrogen species and antioxidant defenses, plays a pivotal role in the pathogenesis of these disorders. However, the mechanisms underlying this imbalance remain incompletely understood. Addressing these processes through personalized medicine strategies could offer promising therapeutic avenues for various neurodegenerative conditions.
This Special Issue will consolidate efforts from both the medical and research communities to investigate and clarify the contribution of oxidative stress in neurodegenerative diseases. Our objective is to identify novel therapeutic strategies for early detection, diagnosis, risk assessment, and treatment through personalized medicine approaches. Your contributions will be essential in providing new knowledge to tackle neurodegenerative diseases and in making the few available treatments more effective through a personalized medicine approach.
We will consider original research, systematic reviews, and experimental pre-clinical and clinical studies that explore the role of personalized medicine in addressing oxidative stress in neurodegenerative disorders.
Relevant topics include the following:
- Alzheimer's disease;
- Parkinson's disease;
- Amyotrophic lateral sclerosis;
- Huntington's disease;
- Mitochondrial dysfunction;
- Neuroinflammation;
- Neuronal death;
- Impaired protein degradation pathways;
- Novel biomarkers for neurodegenerative diseases;
- Emerging therapies in neurodegenerative diseases;
- Neuroprotective strategies.
We particularly encourage submissions that employ innovative methodologies such as genomics, pharmacogenomics, artificial intelligence-driven predictive models, transcriptomics, proteomics, and machine learning models for patient stratification. These approaches are essential for advancing precision medicine in the context of oxidative stress and neurodegenerative diseases.
Dr. Lucia Buccarello
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- neurodegeneration
- biomarkers
- neuroprotection
- protein oxidation
- neuroinflammation
- protein degradation
- personalized medicine
- intracellular signaling
- neuronal death
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