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Personalized Diagnosis and Treatment of Digestive System Disorders
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Personalized Diagnosis and Treatment of Digestive System Disorders

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: 10 February 2026 | Viewed by 309

Special Issue Editor

Dr. Gengqing Song

E-Mail Website
Guest Editor
Department of Gastroenterology and Hepatology, MetroHealth Medical Center/Case Western Reserve University, Cleveland, OH 44106, USA
Interests: neurogastroenterology; gastrointestinal motility disorders; functional gastrointestinal disorders; precision medicine; personalized gastroenterology; neuromodulation; gastrointestinal disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are delighted to invite you to contribute to a Special Issue of the Journal of Personalized Medicine (JPM) entitled "Personalized Diagnosis and Treatment of Digestive System Disorders". Advances in precision medicine have significantly transformed our approach to gastrointestinal (GI) diseases, providing innovative diagnostic methods and tailored treatments to individual patient profiles. This Special Issue aims to highlight cutting-edge research and clinical applications focused on personalized strategies in diagnosing and treating digestive system disorders, encompassing functional GI disorders, motility issues, inflammatory bowel diseases, hepatobiliary disorders, gastrointestinal oncology, and microbiota-based interventions.

We welcome submissions of original research, comprehensive reviews, other types, and innovative methodologies that elucidate personalized approaches in gastroenterology. Topics may include, but are not limited to the following:

  • Precision diagnostics and biomarkers in gastrointestinal diseases;
  • Personalized treatment modalities in functional gastrointestinal disorders;
  • Advances in gastrointestinal motility diagnostics and tailored therapies;
  • Individualized microbiome interventions;
  • Pharmacogenomics in gastrointestinal therapeutics;
  • Personalized management strategies for inflammatory bowel diseases;
  • Gastrointestinal oncology and targeted personalized therapies;
  • Integration of artificial intelligence in personalized gastroenterology.

We look forward to your valuable contributions that will enhance our understanding and management of digestive system disorders through personalized medicine.

Dr. Gengqing Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • gastrointestinal disorders
  • precision diagnostics
  • functional GI disorders
  • gastrointestinal motility
  • microbiome
  • pharmacogenomics
  • gastrointestinal oncology

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Published Papers (1 paper)

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Research

13 pages, 3532 KB  
Article
The Hidden Burden of Gastroparesis in Chronic Kidney Disease: Evidence from Inpatient and Outpatient Cohorts for Personalized Care
by Xiaoliang Wang, Omar Almetwali, Armando Marino-Melendez, Darwin Tan, Jiayan Wang and Gengqing Song
J. Pers. Med. 2025, 15(12), 600; https://doi.org/10.3390/jpm15120600 - 4 Dec 2025
Viewed by 140
Abstract
Background/Objectives: Patients with chronic kidney disease (CKD) frequently experience upper gastrointestinal (GI) symptoms such as epigastric discomfort, nausea, vomiting, and early satiety. These symptoms can contribute to malabsorption and intermittent dehydration, ultimately accelerating the decline of residual renal function. However, they are often [...] Read more.
Background/Objectives: Patients with chronic kidney disease (CKD) frequently experience upper gastrointestinal (GI) symptoms such as epigastric discomfort, nausea, vomiting, and early satiety. These symptoms can contribute to malabsorption and intermittent dehydration, ultimately accelerating the decline of residual renal function. However, they are often attributed to electrolyte imbalances or fluid overload, and the possibility of underlying gastroparesis is frequently overlooked by both patients and caregivers. This study aimed to provide new insights into the relationship between CKD and gastroparesis through a dual, population-based retrospective analysis that incorporated both inpatient and outpatient data. Methods: From the National Inpatient Sample (NIS) database, 3,579,372 patients diagnosed with gastroparesis, with or without CKD, were identified. From the TriNetX database, 6,263,251 patients presenting to ambulatory clinics with a chief complaint of nausea and vomiting were included. In both datasets, gastroparesis was defined using ICD-10-CM codes. Results: In the inpatient cohort, the prevalence of gastroparesis increased in proportion to CKD severity, with the highest likelihood observed in advanced stages compared to patients without CKD. An increased risk of gastroparesis was also observed in the outpatient CKD cohort from an independent TriNetX database, while the severity-dependent phenotype was not consistent. However, after rigorous propensity score matching, advanced CKD remained significantly associated with higher odds of gastroparesis, with the greatest risk observed in patients with end-stage renal disease (ESRD). Conclusions: These findings, validated across two large and independent datasets representing both inpatient and outpatient populations, demonstrate a consistent association between CKD severity and gastroparesis. They highlight the importance of routine screening and early management of gastroparesis in patients with advanced CKD to improve outcomes and reduce disease burden for CKD patients with sign of early satiety or dyspepsia. Full article
(This article belongs to the Special Issue Personalized Diagnosis and Treatment of Digestive System Disorders)
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