Fungal Metabolomics and Genomics, 2nd Edition

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Genomics, Genetics and Molecular Biology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 408

Special Issue Editors


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Guest Editor
Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China
Interests: fungal synthetic biology; natural product chemistry; biosynthetic pathway
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Guest Editor
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 3 Taicheng Road, Yangling 712100, China
Interests: structure identification and activity evaluation of natural active ingredients from macrofungi (mushrooms); biosynthesis and green manufacturing of active ingredients of medicinal fungi; nuclear and mitochondrial genomes of macrofungi, and their inheritance and evolution
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State Key Laboratory of Plateau Ecology and Agriculture, Qinghai Academy of Animal and Veterinary Science, Qinghai University, Xining 810016, China
Interests: plant protection; edible and medicinal fungi resources
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Special Issue Information

Dear Colleagues,

Metabolomics and genomics have had major impacts on fungal research. This Special Issue of the JoF is dedicated to exploring the frontiers of these aspects, highlighting the latest breakthroughs and innovative approaches in these dynamic fields. We aim to present a collection of research that delves into the molecular mechanisms of fungi, providing insights into their genetic makeup, metabolic pathways, and the regulation of these processes.

We encourage contributions from metabolomics- and genomics-related studies, and we welcome studies on transcriptomics and proteomics, as well as multi-omics interactions. Original research, reviews, and communications are all welcome. We are excited to showcase the innovative work of our contributors and hope this Special Issue will bring insights to the scientific community.

Prof. Dr. Chengwei Liu
Dr. Jianzhao Qi
Dr. Xiuzhang Li
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • genomics
  • multi-omics
  • metabolic pathway
  • biosynthesis

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Published Papers (1 paper)

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Research

19 pages, 7841 KiB  
Article
Co-Expression Network Analysis Suggests PacC Transcriptional Factor Involved in Botryosphaeria dothidea Pathogenicity in Chinese Hickory
by Dong Liang, Yiru Jiang, Wei Ai, Yu Zhang, Chengxing Mao, Tianlin Ma and Chuanqing Zhang
J. Fungi 2025, 11(8), 580; https://doi.org/10.3390/jof11080580 - 4 Aug 2025
Viewed by 299
Abstract
Botryosphaeria dothidea is the causative agent of Chinese hickory trunk canker, which poses significant threat to the production of Chinese hickory (Carya cathayensis Sarg.). Previous studies reported that endophytic–pathogenic phase transition, also referred to as latent infection, plays an important role in [...] Read more.
Botryosphaeria dothidea is the causative agent of Chinese hickory trunk canker, which poses significant threat to the production of Chinese hickory (Carya cathayensis Sarg.). Previous studies reported that endophytic–pathogenic phase transition, also referred to as latent infection, plays an important role in the interaction of Botryosphaeria dothidea with various host plants, including Chinese hickory. However, the mechanism underlying this phase transition is not well understood. Here, we employed RNA-Seq to investigate transcriptional changes in B. dothidea during its phase transition upon interaction with Chinese hickory. A co-expression network was generated based on 6391 differentially expressed genes (DEGs) identified from different infection stages and temperature treatments. One co-expressed module was found that highly correlated with temperature treatments which simulated conditions of B. dothidea latent infection in the field. Subsequently, 53 hub genes were detected, and gene ontology (GO) enrichment analysis revealed three categories of enriched GO terms: transmembrane transport or activity, ion homeostasis or transport, and carbohydrate metabolism. One PacC transcriptional factor (BDLA_00001555, an ambient pH regulator), and one endo-β-1,3-glucanase (BDLA_00010249) were specifically upregulated under temperature treatments that corresponded with the activation stage of B. dothidea’s pathogenic state. The knockout mutant strain of BDLA_00001555 demonstrated defective capability upon the activation of the pathogenic state. This confirmed that BDLA_00001555, the PacC transcriptional factor, plays an important role in the latent infection phase of B. dothidea. Our findings provide insights into the pathogenic mechanism of Chinese hickory trunk canker disease. Full article
(This article belongs to the Special Issue Fungal Metabolomics and Genomics, 2nd Edition)
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