Fungal Biosynthesis

A special issue of Journal of Fungi (ISSN 2309-608X).

Deadline for manuscript submissions: 1 May 2026 | Viewed by 201

Special Issue Editors


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Guest Editor
Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang, College of Life Science, Northeast Forestry University, Harbin 150040, China
Interests: fungal synthetic biology; natural product chemistry; biosynthetic pathway
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Guest Editor
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, China
Interests: fungal natural products; biosynthesis or combinatorial biosynthesis; novel enzymes or catalytic mechanism; natural product (total) synthesis; biological function of natural or semisynthetic products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Fungi, as important biological resources, exhibit broad application potential for their metabolites in fields such as medicine, food, and agriculture. With advancements in genomics and metabolomics, researchers have made significant progress in discovering novel compounds and optimizing synthesis pathways, providing new strategies for practical applications.

This Special Issue focuses on fungal biosynthesis research, exploring the discovery and bioactivity of fungal metabolites, the elucidation of biosynthetic pathways, and the applications of synthetic biology, as well as gene mining and enzyme function analysis.

Topics of Interest

  1. Chemical structures and bioactivity studies of fungal metabolites.
  2. Elucidation of biosynthetic pathways and functional identification of key enzymes.
  3. Applications of synthetic biology techniques in optimizing fungal metabolism.
  4. The role of gene mining and transcriptomics in metabolite synthesis.
  5. Potential application cases of fungal metabolites in medicine and agriculture.

Prof. Dr. Chengwei Liu
Prof. Dr. Xiaolong Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal metabolites
  • biosynthetic pathways
  • synthetic biology
  • gene mining
  • enzyme function

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Published Papers (1 paper)

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Review

27 pages, 3196 KB  
Review
Fungal Sphingolipids: Biosynthesis Pathways, Structural Features and Biological Functions
by Zixin Xue, Liuxi Wang and Chunmei Du
J. Fungi 2026, 12(2), 113; https://doi.org/10.3390/jof12020113 - 5 Feb 2026
Abstract
Sphingolipids are a class of amphipathic lipids characterized by a sphingoid base backbone, which can be classified into glycosphingolipids and sphingomyelins. They exhibit structural complexity and functional diversity, being widely distributed in eukaryotes and some bacterial species. Sphingolipids are important regulators of signal [...] Read more.
Sphingolipids are a class of amphipathic lipids characterized by a sphingoid base backbone, which can be classified into glycosphingolipids and sphingomyelins. They exhibit structural complexity and functional diversity, being widely distributed in eukaryotes and some bacterial species. Sphingolipids are important regulators of signal transduction and cellular homeostasis and are involved in numerous biological processes, including cell polarity establishment, energy metabolism, proliferation, and differentiation. However, research on fungal sphingolipids remains limited. This review provides an overview of sphingolipid species, structural features, and their biosynthesis and degradation in fungi. It also summarizes their essential functions in maintaining cell membrane structure, influencing morphological development, pathogenicity, and homeostasis, and participating in apoptosis. Additionally, the potential of antifungal agents targeting the sphingolipid pathway and their application prospects are discussed. Finally, current challenges and future directions in fungal sphingolipid research are highlighted to support the investigation of their mechanisms and the development of antifungal therapies targeting sphingolipid metabolic pathways. Full article
(This article belongs to the Special Issue Fungal Biosynthesis)
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