Injectable Hydrogels for Cell and Drug Delivery

Abstract submission deadline

30 April 2025

Manuscript submission deadline

30 June 2025

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Topic Information

Dear Colleagues,

Most cells and drugs require appropriate formulation for their successful application as pharmaceuticals. The use of polymer-based hydrogel biomaterials for the delivery of drugs and recruitment of cells to promote tissue regeneration in the body is of growing interest. This Topic will invite original research and review articles focusing primarily on the principles and strategies employed for the design, formulation, characterization, evaluation, and translation of novel injectable hydrogels for pharmaceuticals and tissue engineering applications. It will accomplish this by discussing and/or presenting recent innovative advances in polymers, their building blocks, and the engineering chemistries for their formation, whether by chemical crosslinking reactions or physical interactions. Potential topics include, but are not limited to, the following:

• drug delivery hydrogels
• pharmacokinetics in hydrogels
• stimuli-responsive polymers
• natural polymers
• hydrogel nanoparticles
• injectable hydrogels
• drug encapsulation
• dynamic hydrogels
• sustained drug release
• targeted drug delivery

Dr. Prabir Patra
Prof. Dr. Ziyad S. Haidar
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Cells cells	5.1	9.9	2012	17 Days	CHF 2700	Submit
Materials materials	3.1	5.8	2008	13.9 Days	CHF 2600	Submit
Molecules molecules	4.2	7.4	1996	15.1 Days	CHF 2700	Submit
Pharmaceutics pharmaceutics	4.9	7.9	2009	15.5 Days	CHF 2900	Submit
Separations separations	2.5	3.0	2014	15.1 Days	CHF 2600	Submit
Nanomaterials nanomaterials	4.4	8.5	2010	14.1 Days	CHF 2400	Submit

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Published Papers (1 paper)

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All Cells Materials Molecules Pharmaceutics Separations Nanomaterials

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15 pages, 1446 KiB  

Open AccessArticle

Efficient Hydroxyapatite Extraction from Salmon Bone Waste: An Improved Lab-Scaled Physico-Chemico-Biological Process

by Francisco Muñoz, Ziyad S. Haidar, Andreu Puigdollers, Ignacio Guerra, María Cristina Padilla, Nicole Ortega, Mercedes Balcells and María José García

Molecules 2024, 29(17), 4002; https://doi.org/10.3390/molecules29174002 - 24 Aug 2024

Cited by 3 | Viewed by 1929

Abstract

The demand for novel tissue grafting and regenerative wound care biomaterials is growing as traditional options often fall short in biocompatibility, functional integration with human tissue, associated cost(s), and sustainability. Salmon aquaculture generates significant volumes of waste, offering a sustainable opportunity for biomaterial [...] Read more.

The demand for novel tissue grafting and regenerative wound care biomaterials is growing as traditional options often fall short in biocompatibility, functional integration with human tissue, associated cost(s), and sustainability. Salmon aquaculture generates significant volumes of waste, offering a sustainable opportunity for biomaterial production, particularly in osteo-conduction/-induction, and de novo clinical/surgical bone regeneration. Henceforth, this study explores re-purposing salmon waste through a standardized pre-treatment process that minimizes the biological waste content, followed by a treatment stage to remove proteins, lipids, and other compounds, resulting in a mineral-rich substrate. Herein, we examined various methods—alkaline hydrolysis, calcination, and NaOH hydrolysis—to better identify and determine the most efficient and effective process for producing bio-functional nano-sized hydroxyapatite. Through comprehensive chemical, physical, and biological assessments, including Raman spectroscopy and X-ray diffraction, we also optimized the extraction process. Our modified and innovative alkaline hydrolysis–calcination method yielded salmon-derived hydroxyapatite with a highly crystalline structure, an optimal Ca/P ratio, and excellent biocompatibility. The attractive nano-scale cellular/tissular properties and favorable molecular characteristics, particularly well-suited for bone repair, are comparable to or even surpass those of synthetic, human, bovine, and porcine hydroxyapatite, positioning it as a promising candidate for use in tissue engineering, wound healing, and regenerative medicine indications. Full article

(This article belongs to the Topic Injectable Hydrogels for Cell and Drug Delivery)

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