The 15th Anniversary of JFB—Endodontic Biomaterials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 299

Special Issue Editor


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Guest Editor
Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal
Interests: pulp biology and regeneration; biocompatibility; bioactivity; bioceramic materials; endodontics; chlorhexidine; animal models
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Special Issue Information

Dear Colleagues,

The year 2025 marks the 15th anniversary of the Journal of Functional Biomaterials, a peer-reviewed, open access journal containing research relevant to the field of materials for biomedical use. So far, JFB has published more than 1700 papers from more than 9000 authors. We appreciate each author, reviewer, and academic editor whose support has brought us to where we are today.

To celebrate this significant milestone, we are publishing a Special Issue entitled “The 15th Anniversary of JFB—Endodontic Biomaterials”. Endodontics is currently going through one of the most exciting periods of knowledge expansion within the history of the discipline, especially in terms of the future clinical translation of scientific attainments, largely driven by new insights in pulp biology and biomaterial development.

One of the focuses of biomaterials science is to engineer substances to be used in therapeutic procedures, able to interact with the components of living systems and promote specific treatment goals in order to improve the expected clinical outcomes. The immense advances verified over the last two decades with the introduction of breakthrough materials for root canal filling, vital pulp therapy, and regenerative endodontic procedures represent a leap forward in our capacity to simplify current complex therapeutic approaches in the endodontic field. Hopefully this will allow for more conservative treatment options to manage pulpal and periapical pathology and preserve the natural dentition of our patients.

The aim of this Special Issue is to present the various aspects of biomaterials development and testing, from physicochemical evaluations to biological in vitro and in vivo assessments of performance, before their introduction to clinical use.

Dr. João Miguel Marques dos Santos
Guest Editor

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Keywords

  • biocompatibility
  • in vitro testing
  • in vivo testing
  • bioceramics
  • regenerative endodontics
  • vital pulp therapy
  • root canal filling

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Published Papers (1 paper)

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36 pages, 775 KiB  
Systematic Review
Efficacy of Endodontic Files in Root Canal Retreatment: A Systematic Review of In Vitro Studies
by Anna Soler-Doria, José Luis Sanz, Marcello Maddalone and Leopoldo Forner
J. Funct. Biomater. 2025, 16(8), 293; https://doi.org/10.3390/jfb16080293 - 14 Aug 2025
Abstract
The success rate of root canal treatment is high, but it can fail. In these cases, orthograde root canal retreatment is often the treatment of choice, for which numerous biomaterials are available on the market, including endodontic files. This systematic review aimed to [...] Read more.
The success rate of root canal treatment is high, but it can fail. In these cases, orthograde root canal retreatment is often the treatment of choice, for which numerous biomaterials are available on the market, including endodontic files. This systematic review aimed to study the endodontic files available on the market and establish their efficacy in root canal retreatment. An electronic search of six different databases was performed, and in vitro experimental studies that studied root canal cleaning, debris extrusion, retreatment time, or dentinal damage produced with any of the comparison methods were selected. The quality of the studies was assessed with the QUIN scale. In total, 78 studies were included for the analysis, of which 9 had a high risk of bias, 53 had a moderate risk, and 16 had a low risk. The methods used to evaluate the efficacy of endodontic files in root canal retreatment are heterogeneous. Manual files produce more apical extrusion than rotary files. PTUR files are the most studied endodontic files. It is the file system that leaves the least residual filling material in the canal, takes the least time during retreatment, and removes the greatest amount of dentine. However, no file system achieved the complete removal of the root canal filling material. No consistent pattern emerged across studies when comparing rotary files with continuous and reciprocating rotation in terms of the removal of the filling material, the time required for de-obturation, dentine damage produced, or apical extrusion. Full article
(This article belongs to the Special Issue The 15th Anniversary of JFB—Endodontic Biomaterials)
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