Bioengineered Approaches to Oral-Systemic Disease Diagnostics and Therapeutics

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Biomedical Engineering and Biomaterials".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 491

Special Issue Editor


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Guest Editor
Institute of Endodontics, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal
Interests: pulp biology and regeneration; biocompatibility; bioactivity; bioceramic materials; endodontics; chlorhexidine; animal models
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Special Issue Information

Dear Colleagues,

Oral health is increasingly recognized as a critical determinant of systemic health, with a growing body of evidence linking periodontal diseases and other oral conditions to a range of systemic diseases, including cardiovascular disease, diabetes, and respiratory disorders. The advent of bioengineering technologies offers new pathways to enhance the diagnosis and treatment of oral-systemic conditions, moving beyond traditional practices to harness the power of advanced materials, biotechnologies, and precision medicine.

The approaches to diagnosing oral-systemic diseases involve the development of novel biosensors, nanomaterials, and diagnostic devices capable of providing real-time and highly sensitive detection of biomarkers associated with oral health, paving the way for early diagnosis and timely intervention. In addition, therapeutic strategies targeting oral-systemic diseases are also evolving through bioengineering innovation. The use of targeted drug delivery systems, tissue engineering, and regenerative medicine is revolutionizing the treatment landscape for patients suffering from both oral and systemic conditions.

This Special Issue will highlight current knowledge, emerging diagnostic markers, and therapeutic strategies that bridge dentistry and general medicine. Emphasis will be placed on the role of dental professionals in the early detection of systemic illness and the integration of oral healthcare in broader patient management.

Dr. João Miguel Marques dos Santos
Guest Editor

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Keywords

  • bioengineering
  • oral health
  • systemic diseases
  • diagnostics
  • therapeutics
  • biomarkers

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Published Papers (1 paper)

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Research

11 pages, 3262 KiB  
Article
Evaluation of Mandibular Bone Alterations by Panoramic Radiography: A Potential Tool in the Identification of Signs of Osteopenia and Osteoporosis
by Esdras Gabriel Alves-Silva, Betania Fachetti Ribeiro, Camila Fontes Silva, Rita de Kássia-Alves, Rodrigo Arruda-Vasconcelos, Lidiane Mendes Louzada, Rebecca F. Almeida-Gomes, João Miguel Marques Santos and Brenda P. F. A. Gomes
Bioengineering 2025, 12(7), 746; https://doi.org/10.3390/bioengineering12070746 - 9 Jul 2025
Viewed by 403
Abstract
This study aimed to evaluate the validity of panoramic radiography as an auxiliary method for identifying mandibular bone features consistent with a diagnosis of osteopenia or osteoporosis. Ninety panoramic radiographs were analyzed to assess the quality of the mandibular cortical layer below the [...] Read more.
This study aimed to evaluate the validity of panoramic radiography as an auxiliary method for identifying mandibular bone features consistent with a diagnosis of osteopenia or osteoporosis. Ninety panoramic radiographs were analyzed to assess the quality of the mandibular cortical layer below the mental foramen on both sides of the mandible. Scores C1 (normal), C2 (osteopenia), and C3 (osteoporosis) were attributed according to the cortical morphology. The sample consisted of 78 (86%) women aged 45 years or older and 12 (14%) men older than 60 years old. In 39 (43%) cases, the C1 score was evidenced as the lower mandibular cortical layer was normal on the image. The C2 score was identified in 47 (52%) cases, in which the cortical layer showed semilunar defects. Four (5%) cases presented a C3 score, with the cortical layer showing a clearly porous, thinner bone cortex. The presence of risk behaviors (e.g., smoking and alcoholism) as well as some comorbidities (e.g., systemic arterial hypertension, diabetes mellitus and thyroid disorders) was also observed. Mandibular bone changes were observed in association with a set of risk factors using panoramic radiography. Full article
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