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Recent Advances in Tissue Regeneration and Biomaterials Manufacturing
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Recent Advances in Tissue Regeneration and Biomaterials Manufacturing

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 5721

Special Issue Editors

Dr. Feng Wen

E-Mail Website
Guest Editor
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China
Interests: biomaterials; tissue engineering; bioreactor; stem cell
Prof. Dr. Zuyong Wang

E-Mail Website
Guest Editor
College of Materials and Science, Hunan University, Changsha, China
Interests: biomaterials; 3D printing; manufacturing; scaffold; tissue regeneration
Dr. Yingnan Wu

E-Mail Website
Guest Editor
Department of Orthopeadic Surgery, YLL School of Medicine, National University of Singapore, Singapore, Singapore
Interests: biomaterials; tissue engineering; bioreactor; stem cell; exosomes

Special Issue Information

Dear Colleagues,

Tissue reparation and regeneration is the repairing and restoring of tissue defects by using combinations of biomaterials, biomolecules, and cells. This Special Issue will present some new necessary features associated with biomaterial types and design requirements for tissue regeneration applications, and new trends for future implementations as well. Tissue reparation and regeneration mainly depends on biomaterials and scaffold fabrication methods. Therefore, there have been progressive investigations and development of new biomaterials with different formulations to help and achieve necessary requirements for restoring human body functions. However, temporal and spatial control of therapeutics delivery and advanced diagnostic technology will guide tissue growth and necessary clinic intervention.

This Special Issue is dedicated to understanding the biological principles and manufacturing advances, synchronize the physicochemical properties of biomaterials, and explore their applications for tissue regeneration as well as the development of biomaterials for advanced diagnostic technology.

Dr. Feng Wen
Prof. Dr. Zuyong Wang
Dr. Yingnan Wu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D printing and manufacturing techniques
  • biomaterial
  • scaffold
  • tissue engineering and regeneration
  • wearable healthcare device

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

28 pages, 4286 KiB  
Article
The Impact of the Methacrylation Process on the Usefulness of Chitosan as a Biomaterial Component for 3D Printing
by Marta Klak, Katarzyna Kosowska, Milena Czajka, Magdalena Dec, Sylwester Domański, Agnieszka Zakrzewska, Paulina Korycka, Kamila Jankowska, Agnieszka Romanik-Chruścielewska and Michał Wszoła
J. Funct. Biomater. 2024, 15(9), 251; https://doi.org/10.3390/jfb15090251 - 30 Aug 2024
Cited by 1 | Viewed by 2160
Abstract
Chitosan is a very promising material for tissue model printing. It is also known that the introduction of chemical modifications to the structure of the material in the form of methacrylate groups makes it very attractive for application in the bioprinting of tissue [...] Read more.
Chitosan is a very promising material for tissue model printing. It is also known that the introduction of chemical modifications to the structure of the material in the form of methacrylate groups makes it very attractive for application in the bioprinting of tissue models. The aim of this work is to study the characteristics of biomaterials containing chitosan (BCH) and its methacrylated equivalent (BCM) in order to identify differences in their usefulness in 3D bioprinting technology. It has been shown that the BCM material containing methacrylic chitosan is three times more viscous than its non-methacrylated BCH counterpart. Additionally, the BCM material is characterized by stability in a larger range of stresses, as well as better printability, resolution, and fiber stability. The BCM material has higher mechanical parameters, both mechanical strength and Young’s modulus, than the BCH material. Both materials are ideal for bioprinting, but BCM has unique rheological properties and significant mechanical resistance. In addition, biological tests have shown that the addition of chitosan to biomaterials increases cell proliferation, particularly in 3D-printed models. Moreover, modification in the form of methacrylation encourages reduced toxicity of the biomaterial in 3D constructs. Our investigation demonstrates the suitability of a chitosan-enhanced biomaterial, specifically methacrylate-treated, for application in tissue engineering, and particularly for tissues requiring resistance to high stress, i.e., vascular or cartilage models. Full article
(This article belongs to the Special Issue Recent Advances in Tissue Regeneration and Biomaterials Manufacturing)
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17 pages, 5928 KiB  
Article
Fibrinogen-Based Bioink for Application in Skin Equivalent 3D Bioprinting
by Aida Cavallo, Tamer Al Kayal, Angelica Mero, Andrea Mezzetta, Lorenzo Guazzelli, Giorgio Soldani and Paola Losi
J. Funct. Biomater. 2023, 14(9), 459; https://doi.org/10.3390/jfb14090459 - 5 Sep 2023
Cited by 14 | Viewed by 2864
Abstract
Three-dimensional bioprinting has emerged as an attractive technology due to its ability to mimic native tissue architecture using different cell types and biomaterials. Nowadays, cell-laden bioink development or skin tissue equivalents are still at an early stage. The aim of the study is [...] Read more.
Three-dimensional bioprinting has emerged as an attractive technology due to its ability to mimic native tissue architecture using different cell types and biomaterials. Nowadays, cell-laden bioink development or skin tissue equivalents are still at an early stage. The aim of the study is to propose a bioink to be used in skin bioprinting based on a blend of fibrinogen and alginate to form a hydrogel by enzymatic polymerization with thrombin and by ionic crosslinking with divalent calcium ions. The biomaterial ink formulation, composed of 30 mg/mL of fibrinogen, 6% of alginate, and 25 mM of CaCl2, was characterized in terms of homogeneity, rheological properties, printability, mechanical properties, degradation rate, water uptake, and biocompatibility by the indirect method using L929 mouse fibroblasts. The proposed bioink is a homogeneous blend with a shear thinning behavior, excellent printability, adequate mechanical stiffness, porosity, biodegradability, and water uptake, and it is in vitro biocompatible. The fibrinogen-based bioink was used for the 3D bioprinting of the dermal layer of the skin equivalent. Three different normal human dermal fibroblast (NHDF) densities were tested, and better results in terms of viability, spreading, and proliferation were obtained with 4 × 106 cell/mL. The skin equivalent was bioprinted, adding human keratinocytes (HaCaT) through bioprinting on the top surface of the dermal layer. A skin equivalent stained by live/dead and histological analysis immediately after printing and at days 7 and 14 of culture showed a tissuelike structure with two distinct layers characterized by the presence of viable and proliferating cells. This bioprinted skin equivalent showed a similar native skin architecture, paving the way for its use as a skin substitute for wound healing applications. Full article
(This article belongs to the Special Issue Recent Advances in Tissue Regeneration and Biomaterials Manufacturing)
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