Application of Dentin Matrix in Tissue Regeneration

Dear Colleagues,

The idea of DDM was largely developed by Urist in 1965. Yeomans and Urist were the first to use extracted teeth as a graft material in 1967, where they discovered and verified that decalcified dentin matrix can induce bone formation.

Since 2010, many preclinical studies have reported that demineralized dentin matrix (DDM) is an “inductive substrate” because the bone inducer originating from the extracellular dentin matrix has similar osteoinductivity that transforms the mesenchymal fibroblasts into cartilage or bone cells. One of the transforming factors present in both the dentin and bone matrix is BMP. Consequently, clinical trials have shown promising results for the past decade.

This Special Issue will be a great opportunity to bring together all research related to dentin matrix that are scattered around various countries among researchers, clinicians, etc., because the historical background of dentin matrix is not so long. In order that we can discuss where we are and where we wish to go in the future with dentin matrix as a reliable, evidence-based biomaterial, we need to spread awareness of this novel approach in the dental field.

Dentin matrix, in the form of powder, block, and membrane, has evolved very quickly from a novel scaffold for tissue regeneration to a carrier of growth factors and composites with stem cells and drug delivery systems—from alveolar bone regeneration to dentin repair and viable pulp regeneration. 

We are looking for papers on case reports, case series, cohort studies, or randomized controlled clinical trials (RCT) on the topics of growth factors in dentin, dentin extracts, dentin regeneration, dentin as drug delivery system, and dentin as a carrier of growth factors and stem cells.

Dr. In-Woong Um
Prof. Dr. Masaru Murata
Guest Editors

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