Functional and Responsive Biomaterials for Tissue Engineering and Regenerative Medicine

Dear Colleagues,

In recent years, the paradigm of biomaterials in tissue engineering and regenerative medicine has shifted from passive scaffolds to dynamic, functional systems that actively communicate with the biological environment. This Special Issue will showcase cutting-edge advances in functional biomaterials, materials engineered not merely for structural support but to sense external cues, enhance vascularization, and modulate cellular responses. We welcome contributions focusing on stimuli-responsive materials (e.g., pH, enzymatic, thermal, and mechanical stimuli), materials functionalized with biologically active signals (e.g., peptides, growth factors, and nucleic acids), immunomodulatory scaffolds, vascularization strategies, biofabrication, organ-on-chip interfaces, and biomaterial-based disease models.

We are particularly interested in works that combine multidisciplinary approaches, for example, materials science, cell biology, mechanobiology, and computational modeling, to create responsive biomaterial systems for regenerative therapies or in vitro models. This Special Issue will showcase novel design principles, mechanistic understanding, translational potential, and challenges in scale-up and clinical translation. Ultimately, our aim is to chart a path toward "smart" regenerative materials that instruct, and adapt to, the host environment, bridging the gap between bench and bedside. 

Dr. Naghmeh Abbasi
Prof. Dr. Min Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.