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Multifunctional Biomaterials for Volumetric Muscle Loss
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Multifunctional Biomaterials for Volumetric Muscle Loss

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 1732

Special Issue Editors

Dr. Koyal Garg

E-Mail Website
Guest Editor
Biomedical Engineering School of Engineering, Saint Louis University School of Science and Engineering, St. Louis, MO 63103, USA
Interests: skeletal muscle; tissue engineering; biomaterials; extracellular matrix; regenerative medicine; angiogenesis; immunomodulation; volumetric muscle loss
Dr. Michael J. Mcclure

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 843068, USA
Interests: skeletal muscle; cell and tissue engineering; biomaterials; extracellular matrix; innervation; rehabilitation; volumetric muscle loss
Special Issues, Collections and Topics in MDPI journals
Dr. Jonathan Grasman

E-Mail Website
Guest Editor
Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA
Interests: tissue engineering; volumetric muscle loss; biopolymers; 3D tissue models; stem cells; tissue innervation; soft tissue regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Musculoskeletal trauma often disrupts intramuscular neural and vascular networks to denervate existing motor units and causes fibrosis and inflammation, hindering muscle mass, strength, and size recovery. While current scaffolds for muscle repair can enhance myogenesis and myofiber repair, they lack the ability to promote reinnervation alongside angiogenesis and often do not possess anti-inflammatory and antifibrotic properties. This call for papers seeks submissions on multifunctional scaffolds that can not only enhance muscle repair but also promote other processes critical for recovery, such as reinnervation, angiogenesis, and/or modulation of inflammation and fibrosis. We invite review articles and original research describing the design and application of such scaffolds for muscle recovery post-injury.

Dr. Koyal Garg
Dr. Michael J. Mcclure
Dr. Jonathan Grasman
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • muscle trauma
  • soft tissue regeneration
  • fibrosis
  • inflammation
  • neurovascular injury
  • biomaterials
  • biopolymers
  • tissue engineering

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Published Papers (1 paper)

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Research

19 pages, 3962 KiB  
Article
Extrusion-Based Printing of Myoblast-Loaded Fibrin Microthreads to Induce Myogenesis
by Hanson S. Lee, Bryanna L. Samolyk and George D. Pins
J. Funct. Biomater. 2025, 16(1), 21; https://doi.org/10.3390/jfb16010021 - 10 Jan 2025
Viewed by 1303
Abstract
Large skeletal muscle injuries such as volumetric muscle loss (VML) disrupt native tissue structures, including biophysical and biochemical signaling cues that promote the regeneration of functional skeletal muscle. Various biofabrication strategies have been developed to create engineered skeletal muscle constructs that mimic native [...] Read more.
Large skeletal muscle injuries such as volumetric muscle loss (VML) disrupt native tissue structures, including biophysical and biochemical signaling cues that promote the regeneration of functional skeletal muscle. Various biofabrication strategies have been developed to create engineered skeletal muscle constructs that mimic native matrix and cellular microenvironments to enhance muscle regeneration; however, there remains a need to create scalable engineered tissues that provide mechanical stability as well as structural and spatiotemporal signaling cues to promote cell-mediated regeneration of contractile skeletal muscle. We describe a novel strategy for bioprinting multifunctional myoblast-loaded fibrin microthreads (myothreads) that recapitulate the cellular microniches to drive myogenesis and aligned myotube formation. We characterized myoblast alignment, myotube formation, and tensile properties of myothreads as a function of cell-loading density and culture time. We showed that increasing myoblast loading densities enhances myotube formation. Additionally, alignment analyses indicate that the bioprinting process confers myoblast alignment in the constructs. Finally, tensile characterizations suggest that myothreads possess the structural stability to serve as a potential platform for developing scalable muscle scaffolds. We anticipate that our myothread biofabrication approach will enable us to strategically investigate biophysical and biochemical signaling cues and cellular mechanisms that enhance functional skeletal muscle regeneration for the treatment of VML. Full article
(This article belongs to the Special Issue Multifunctional Biomaterials for Volumetric Muscle Loss)
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