Advances in Biomaterials for Oral and Dental Tissue Engineering

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Dental Biomaterials".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 2347

Special Issue Editors


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Guest Editor
Department of Conservative Dentistry, Medical University of Warsaw, 02-097 Warsaw, Poland
Interests: dentistry; tissue engineering; periodontology; periodontal regeneration

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Guest Editor
Department of Periodontology and Oral Mucosa Diseases, Medical University of Warsaw, 02-097 Warsaw, Poland
Interests: periodontology; periodontal regeneration; guided tissue regeneration; regenerative biomaterials; periodontal plastic surgery; gingival recession; oral surgery; oral implantology; oral microbiology; oral medicine
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Special Issue Information

Dear Colleagues,

This Special Issue, “Advances in Biomaterials for Oral and Dental Tissue Engineering”, examines the combined impact of materials, advanced techniques and engineered oral tissues.

Oral tissue engineering refers to the development of biomaterials for repair or regeneration utilizing tissue engineering technologies, and it is becoming a more prominent area of research. Currently, biologically inert materials are unable to fulfill clinical requirements; therefore, tissue-engineered biomaterials with bioactive properties are urgently needed.

In dental medicine, tissue reconstruction is of significant interest in oral surgery, periodontics, orthodontics, endodontics and daily clinical practice. Current clinical approaches involve various techniques, ranging from the traditional use of tissue grafts to more innovative regenerative procedures, such as tissue engineering.

This Special Issue explores the role of biomaterials used for oral tissue engineering, with particular emphasis being placed on hard and soft intraoral tissues. Further topics of interest include material characterization, modification, biocompatibility and biotoxicity.

Dr. Aniela Brodzikowska
Dr. Bartlomiej Gorski
Guest Editors

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Keywords

  • tissue engineering
  • biomaterials
  • growth factors
  • regenerative dentistry
  • regenerative medicine

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Published Papers (2 papers)

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Research

12 pages, 1836 KB  
Article
Influence of the Topography of Zirconium Treated with Laser Micropatterning on Periodontal Ligament Stem Cells: An In Vitro Study
by Ildefonso Serrano-Belmonte, Alba Rico-Molina, Juan Ignacio Rosales-Leal, Guillermo Lorite-Méndez, Miguel Ángel Rodríguez-Valverde, Clara Serna-Muñoz and Ascensión Martínez-Cánovas
J. Funct. Biomater. 2026, 17(3), 132; https://doi.org/10.3390/jfb17030132 - 9 Mar 2026
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Abstract
Zirconium is a widely used material in the field of dentistry, employed for implants and their components as well as for the creation of crowns and veneers. Given that its biocompatibility has been studied and demonstrated in various fields of application, it is [...] Read more.
Zirconium is a widely used material in the field of dentistry, employed for implants and their components as well as for the creation of crowns and veneers. Given that its biocompatibility has been studied and demonstrated in various fields of application, it is necessary to analyze how surface modification of this material influences its properties. The purpose of this study was to analyze the biocompatibility, initial adhesion (48 h), and morphology of periodontal ligament stem cells (PDLSCs) seeded on different zirconium surfaces treated with laser micropatterning, as well as plastic coverslips as a control. The Neubauer chamber was used to count the cells adhered to each of the sets, and confocal and scanning electron microscopy were employed to examine the adhesion and morphology of periodontal ligament stem cells on each of the zirconium surfaces studied. Results: Statistically significant differences were found in terms of primary cell adhesion, with sets 3 (grid topography) and 4 (channel topography) showing the most favorable characteristics for fibroblast adhesion. It was concluded that regular and moderately rough surfaces promoted better cell proliferation and development. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Oral and Dental Tissue Engineering)
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14 pages, 2807 KB  
Article
Effects of Caffeine on Dental Mesenchymal Stem Cells: Implications for Regenerative Applications
by Axel Alejandro Lugo-Sanchez, Patricia Alejandra Chavez-Granados, Carlos A. Jurado, Ziyad Allahem, Jorge Emmanuel Ramirez-Lopez, Christian Andrea Lopez-Ayuso, Benjamin Aranda-Herrera, Abdulrahman Alshabib and Rene Garcia-Contreras
J. Funct. Biomater. 2025, 16(9), 314; https://doi.org/10.3390/jfb16090314 - 29 Aug 2025
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Abstract
Periodontal therapy remains a complex task in dentistry as current methodologies often tend to induce tissue repair rather than regeneration. Caffeine is an alkaloid found in multiple natural sources, which has been reported to have multiple beneficial effects, such as promoting adipogenic differentiation, [...] Read more.
Periodontal therapy remains a complex task in dentistry as current methodologies often tend to induce tissue repair rather than regeneration. Caffeine is an alkaloid found in multiple natural sources, which has been reported to have multiple beneficial effects, such as promoting adipogenic differentiation, a key factor in tissue regeneration. Unfortunately, it has also been reported to decrease cell viability and reduce osteogenic and chondrogenic differentiation, both of which play an important role in regenerative medicine. In this study, we aimed to find a non-cytotoxic dose of purified caffeine over dental pulp stem cells (DPSCs) that could provide its beneficial effects over adipogenesis, while reducing the negative effect upon osteogenesis and chondrogenesis. Additional experiments were conducted to determine its impact upon the expression of pro-inflammatory enzymes, and antibacterial assays to assess a potential antibacterial effect. The results attested that purified caffeine at a dose of 8.03 μM holds no viability reduction effect, nor has any impact on the expression of pro-inflammatory enzymes, promotes adipogenic differentiation, and does not negatively affect osteogenic or chondrogenic differentiation, with any antibacterial effect against Streptococcus mutans, Escherichia coli, and Staphylococcus aureus. These findings suggest that purified caffeine at a dose of 8.03 μM has the potential to aid in the field of regenerative dentistry. Full article
(This article belongs to the Special Issue Advances in Biomaterials for Oral and Dental Tissue Engineering)
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