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Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes
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Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 2016

Special Issue Editors

Dr. Ahmad Mahamid

E-Mail Website
Guest Editor
1. Technion Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa 3109601, Israel
2. Carmel Medical Center, Department of Surgery, Haifa 3436212, Israel
Interests: HPB surgery; minimal invasive approaches for HPB surgery; surgical oncology; abdominal organ transplantation
Dr. Riad Haddad

E-Mail Website
Guest Editor
1. Technion Israel Institute of Technology, Rappaport Faculty of Medicine, Haifa 3109601, Israel
2. Carmel Medical Center, Department of Surgery, Haifa 3436212, Israel
Interests: HPB surgery; minimal invasive approaches for HPB surgery; surgical oncology

Special Issue Information

Dear Colleagues,

This issue delves into the transformative advancements reshaping the landscape of hepatobiliary and pancreatic (HPB) surgery, focusing on the synergistic interplay between innovative surgical techniques, perioperative clinical care optimization, and refined prognostication methods. HPB surgery, a field characterized by its complexity and high-stakes nature, demands constant evolution to minimize morbidity and mortality while maximizing long-term survival rates. This necessitates a concerted effort to refine every aspect of patient care, from initial diagnosis and staging to the perioperative period and long-term follow-up.

This Special Issue will serve as a platform to showcase cutting-edge research and clinical experience across several key areas. First, we solicit contributions detailing advancements in minimally invasive surgical techniques, including but not limited to laparoscopy, robotics, and single-incision surgery. Studies comparing outcomes with traditional open techniques, emphasizing metrics such as reduced operative time, decreased blood loss, shorter hospital stays, and improved cosmetic results, are especially encouraged. A second key area of focus will be on optimizing perioperative clinical care. We welcome submissions detailing innovative strategies to expedite recovery and minimize postoperative complications. Finally, the issue will address the critical need for more precise prognostication in HPB surgery. We invite submissions presenting research on advanced prognostic biomarkers, novel risk stratification models, and the application of machine learning techniques to improve the prediction of treatment response, recurrence rates, and overall survival. Studies comparing the efficacy of different prognostic tools and their impact on treatment decisions will be particularly valuable.

Ultimately, this Special Issue aims to provide a comprehensive overview of the current state-of-the-art in HPB surgery, offering valuable insights for surgeons, clinicians, researchers, and healthcare professionals dedicated to improving patient care. By disseminating these crucial advancements, we aim to collectively advance the science and practice of HPB surgery and enhance the lives of patients worldwide.

Dr. Ahmad Mahamid
Dr. Riad Haddad
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver surgery
  • pancreas surgery
  • biliary surgery
  • robotic HPB surgery
  • single incision surgery
  • prognostic biomarkers
  • perioperative clinical care
  • postoperative complications

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 1017 KB  
Article
L-FABP as a Potential Biomolecular Marker of Liver Graft Injury
by Ana Kalamutova, Danaja Plevel, Mihajlo Djokic, Ales Jerin, Blaž Trotovšek and Miha Petric
J. Clin. Med. 2025, 14(20), 7404; https://doi.org/10.3390/jcm14207404 - 20 Oct 2025
Viewed by 501
Abstract
Background: In recent years, indications for liver transplantation have expanded, while the age of transplant recipients has significantly increased due to improvements in perioperative management. As clinical manifestations of posttransplant complications vary and are often nonspecific, the identification of appropriate biomarkers is [...] Read more.
Background: In recent years, indications for liver transplantation have expanded, while the age of transplant recipients has significantly increased due to improvements in perioperative management. As clinical manifestations of posttransplant complications vary and are often nonspecific, the identification of appropriate biomarkers is important for the assessment of graft quality and early recognition of potential complications following liver transplantation. Liver-type FABP (L-FABP) is a small cytoplasmic protein found abundantly in hepatocytes and is involved in the intracellular transport of long-chain fatty acids. Elevated serum levels have been detected in acute and chronic liver failure, kidney failure, and some malignancies. Materials and Methods: We conducted a prospective, single-center study from July 2023 to January 2025, including 29 adult patients who underwent deceased-donor transplantation. Three patients were excluded due to inadequate sample withdrawals. Serum L-FABP was measured preoperatively and on postoperative days 1, 3, 5, 7, and 14. Clinical, surgical, and biochemical data were collected and analyzed using non-parametric statistical tests. Results: L-FABP levels were significantly higher on POD 7 in recipients of grafts from donors ≥ 65 years (p = 0.035), with no corresponding changes in standard liver function markers. While no significant differences in L-FABP levels were found between patients with and without infectious biliary or vascular complications (all p > 0.05), we proved a strong negative correlation between intraoperative blood transfusion volume and L-FABP levels on POD 5 (ρ = −0.677, p < 0.001) and POD 7 (ρ = −0.455, p = 0.025). Conclusions: Our findings suggest that L-FABP holds promise as a biomarker for the early detection of subclinical hepatic graft cellular injury, which is not detected by means of conventional biomarkers for liver function. Full article
(This article belongs to the Special Issue Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes)
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16 pages, 486 KB  
Article
Higher Neutrophil-to-Lymphocyte Ratio and Systemic Immune–Inflammation Index Is Associated with Better Prognosis Following Pancreaticoduodenectomy for Pancreatic Adenocarcinoma
by Esther Kazlow, Elias Rinawi, Eden Gerszman, Samar Mattar, Nabih Essami, Mary Nasir, Aasem Abu Shtaya, Wisam Assaf, Riad Haddad and Ahmad Mahamid
J. Clin. Med. 2025, 14(11), 3762; https://doi.org/10.3390/jcm14113762 - 27 May 2025
Cited by 1 | Viewed by 1199
Abstract
Background: Pancreatic cancer has a high mortality rate worldwide. Most patients progress to advanced stages, often with metastasis, resulting in a low survival rate. Despite advancements in surgical and oncological treatments, early diagnosis and better risk stratification remain critical. Methods: This retrospective [...] Read more.
Background: Pancreatic cancer has a high mortality rate worldwide. Most patients progress to advanced stages, often with metastasis, resulting in a low survival rate. Despite advancements in surgical and oncological treatments, early diagnosis and better risk stratification remain critical. Methods: This retrospective cross-sectional study focused on analyzing data from patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, in order to determine whether the neutrophil-to-lymphocyte ratio (NLR) and other immune–inflammatory markers, such as the systemic immune–inflammation index (SII) and prognostic nutritional index (PNI), can predict postoperative complications and survival outcomes. Results: Analysis of 136 patients revealed that a higher NLR (≥2.5) was significantly associated with longer overall survival (39 months, IQR: 17–100 months; p = 0.004), compared to lower NLR (<2.5; 18 months, IQR: 9–39 months). Higher SII (≥600) was also associated with significantly improved survival (34 months, IQR: 17–114 months; p = 0.001) compared to lower SII (<600; 20 months, IQR: 9–45 months). No significant differences were observed in postoperative complications or other clinical outcomes between NLR groups, although a trend toward more complications in the higher NLR group was noted (p = 0.06). PNI showed no significant impact on survival (PNI < 38.8: 22 months, IQR: 14–60 months; PNI ≥ 38.8: 33 months, IQR: 14–115 months; p = 0.1) or complications (p = 0.8). Conclusions: Our study highlights the prognostic utility of NLR and SII in patients with adenocarcinoma of the head of the pancreas undergoing pancreaticoduodenectomy. Regarding complications, there were no significant differences across groups stratified by NLR, SII, or PNI, suggesting that while NLR and SII are valuable for predicting long-term oncological outcomes in patients undergoing pancreaticoduodenectomy for adenocarcinoma of the head of the pancreas, they may not be reliable indicators of immediate postoperative morbidity. Full article
(This article belongs to the Special Issue Advanced Hepato-Pancreato-Biliary Surgery: Clinical Innovations and Improved Outcomes)
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