Special Issue "Update on Skin Cancers: Non-invasive Diagnostic Tools and Treatment"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 30 April 2023 | Viewed by 883

Special Issue Editor

Dr. Gianluca Nazzaro
E-Mail Website
Guest Editor
1. Department of Physiopathology and Transplantation, University of Milan, Milan, Italy
2. Dermatology Unit - IRCCS Ca' Granda Foundation Ospedale Maggiore Policlinico, Via Pace, 9-20122 Milan, Italy
Interests: dermoscopy; dermatopathology; tropical dermatology; ultrasonography; history of medicine
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Special Issue Information

Dear Colleagues,

The field of dermato-oncology is ever expanding, with substantial advances in non-invasive diagnostic tools, such as dermoscopy, ultrasonography, confocal microscopy and optical coherence tomography. In addition, the incidence of skin cancers, including melanoma and NMSC, is increasing, and the novel diagnostic techniques may enable skin cancers to be diagnosed at earlier stages.

Non-melanoma skin cancers (NMSC) comprise common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rare cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The majority of NMSCs can be successfully treated with surgery or radiotherapy; however, advanced and metastatic stages may require systemic approaches, such as immunotherapy with immune checkpoint inhibitors (ICIs).

Since immunotherapy is not effective in all patients, and can potentially lead to severe adverse effects, an important clinical question is how to properly identify those who could be suitable candidates for this therapeutic choice.

Here, we welcome reviews and original research pertaining to melanoma and NMSC diagnosis and management.

Dr. Gianluca Nazzaro
Guest Editor

Manuscript Submission Information

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Keywords

  • melanoma
  • basal cell carcinoma
  • dermoscopy
  • skin oncology
  • ultrasonography
  • immunotherapy
  • skin tumors
  • nevi

Published Papers (2 papers)

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Research

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Article
Texture Analysis in Diagnosing Skin Pigmented Lesions in Normal and Polarized Light—A Preliminary Report
J. Clin. Med. 2022, 11(9), 2505; https://doi.org/10.3390/jcm11092505 - 29 Apr 2022
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Abstract
The differential diagnosis of benign nevi (BN), dysplastic nevi (DN), and melanomas (MM) represents a considerable clinical problem. These lesions are similar in clinical examination but have different prognoses and therapeutic management techniques. A texture analysis (TA) is a mathematical and statistical analysis [...] Read more.
The differential diagnosis of benign nevi (BN), dysplastic nevi (DN), and melanomas (MM) represents a considerable clinical problem. These lesions are similar in clinical examination but have different prognoses and therapeutic management techniques. A texture analysis (TA) is a mathematical and statistical analysis of pixel patterns of a digital image. This study aims to demonstrate the relationship between the TA of digital images of pigmented lesions under polarized and non-polarized light and their histopathological diagnosis. Ninety pigmented lesions of 76 patients were included in this study. We obtained 166 regions of interest (ROI) images for MM, 166 for DN, and 166 for BN. The pictures were taken under polarized and non-polarized light. Selected image texture features (entropy and difference entropy and long-run emphasis) of ROIs were calculated. Those three equations were used to construct the texture index (TI) and bone index (BI). All of the presented features distinguish melanomas, benign and dysplastic lesions under polarized light very well. In non-polarized images, only the long-run emphasis moment and both indices effectively differentiated nevi from melanomas. TA is an objective method of assessing pigmented lesions and can be used in automatic diagnostic systems. Full article
(This article belongs to the Special Issue Update on Skin Cancers: Non-invasive Diagnostic Tools and Treatment)
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Review

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Review
Identifying Candidates for Immunotherapy among Patients with Non-Melanoma Skin Cancer: A Review of the Potential Predictors of Response
J. Clin. Med. 2022, 11(12), 3364; https://doi.org/10.3390/jcm11123364 - 11 Jun 2022
Viewed by 404
Abstract
Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rarer cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The [...] Read more.
Background: Non-melanoma skin cancer (NMSC) stands as an umbrella term for common cutaneous malignancies, including basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC), together with rarer cutaneous cancers, such as Merkel cell carcinoma (MCC) and other forms of adnexal cancers. The majority of NMSCs can be successfully treated with surgery or radiotherapy, but advanced and metastatic stages may require systemic approaches such as immunotherapy with immune checkpoint inhibitors (ICIs). Summary: Since immunotherapy is not effective in all patients and can potentially lead to severe adverse effects, an important clinical question is how to properly identify those who could be suitable candidates for this therapeutic choice. In this paper, we review the potential features and biomarkers used to predict the outcome of ICIs therapy for NMSCs. Moreover, we analyze the role of immunotherapy in special populations, such as the elderly, immunocompromised patients, organ transplant recipients, and subjects suffering from autoimmune conditions. Key messages: Many clinical, serum, histopathological, and genetic features have been investigated as potential predictors of response in NMSCs treated with ICIs. Although this field of research is very promising, definitive, cost-effective, and reproducible biomarkers are still lacking and further efforts are needed to validate the suggested predictors in larger cohorts. Full article
(This article belongs to the Special Issue Update on Skin Cancers: Non-invasive Diagnostic Tools and Treatment)
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