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Bladder Cancer: Diagnosis, Treatment and Future Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 956

Special Issue Editor


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Guest Editor
1. Department of Clincal Medicine, Arhus University, Aarhus, Denmark
2. Department of Surgery, Queen Ingrid’s Hospital, Nuuk, Greenland
Interests: urology; bladder cancer; nonmuscle invasive bladder cancer; muscle-invasive bladder cancer
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Special Issue Information

Dear Colleagues,

Bladder cancer is a frequent cancer type with a high degree of diversity regarding prognosis and treatment modalities. Its incidence has been almost unaltered over the past few decades despite a focus on smoking and work environment improvements. Thus, the reduction in these factors has been offset by an increasing life expectancy in the Western World.

During the last decade, previous stagnation in the development of new diagnostics and treatment modalities has changed into an explosion in both new local and systemic treatments and the introduction of promising prognostic biomarkers. Immunotherapy showed promising results when introduced, but the initial enthusiasm was quickly changed to a more realistic expectation of just a game-changer in the minority of patients. However, this fact has paved the way for more individualized, tailor-made treatment. We are on the verge of a new future for bladder cancer treatment.

With this Special Issue, “Bladder Cancer: Diagnosis, Treatment and Future Opportunities”, we hope to focus on an up-to-date mapping of the current status of bladder cancer and highlight new promising fields of diagnostics, treatment, and follow-up.

Prof. Dr. Jørgen Bjerggaard Jensen
Guest Editor

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Keywords

  • urology
  • bladder cancer
  • urothelial cancer
  • non-muscle invasive bladder cancer
  • muscle invasive bladder cancer

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Published Papers (1 paper)

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Research

13 pages, 847 KB  
Article
The GreenBladder Study: Early Detection of Bladder Cancer in Greenland Using a Urinary Biomarker
by Nathalie Demuth Fryd, Nadja Albertsen, Simon Bernth-Andersen, Andreas Ernst and Jørgen Bjerggaard Jensen
J. Clin. Med. 2026, 15(2), 761; https://doi.org/10.3390/jcm15020761 - 16 Jan 2026
Viewed by 630
Abstract
Background: Bladder cancer (BC) incidence in Greenland is lower than in other Nordic countries, yet mortality is disproportionately high, suggesting delayed detection. Cystoscopy is the diagnostic gold standard to detect BC, but access in Greenland is often limited by geographic and logistical challenges, [...] Read more.
Background: Bladder cancer (BC) incidence in Greenland is lower than in other Nordic countries, yet mortality is disproportionately high, suggesting delayed detection. Cystoscopy is the diagnostic gold standard to detect BC, but access in Greenland is often limited by geographic and logistical challenges, underscoring the need for more accessible diagnostic tools. Objectives: This study evaluated the performance of the urinary biomarker test Xpert® Bladder Cancer Detection (XBCD) among patients referred for cystoscopy within the Greenlandic healthcare system. Methods: In this prospective observational study, 198 patients referred for urological evaluation due to hematuria or other urologic symptoms were recruited from five Greenlandic towns. All participants provided a urine sample for XBCD testing prior to cystoscopy, which served as the reference standard. Results: Among 194 patients with valid test results, seven BC cases were detected. XBCD identified five true positives and 166 true negatives, yielding a sensitivity of 71.4%, specificity of 88.8%, and a negative predictive value of 98.8%. Conclusions: In this low-prevalence setting, XBCD demonstrated potential as a triage tool to reduce the number of procedures and support earlier BC detection, although findings are limited by the small number of cancer cases. Full article
(This article belongs to the Special Issue Bladder Cancer: Diagnosis, Treatment and Future Opportunities)
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