Protein Kinases in Cardiovascular Pathophysiology
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 4363
Special Issue Editor
Special Issue Information
Dear Colleagues,
We want to draw your attention to a Special Issue focused on Kinases in Cardiovascular Pathophysiology. Kinases and pseudokinases organize a wide range of cellular processes and play integral roles in cardiovascular development, function, and disease, making them attractive therapeutic targets. Dysregulation of kinase signaling has been reported in virtually every cardiovascular pathology, ranging from heart failure with reduced ejection fraction, heart failure with preserved ejection, congenital heart defects, myocardial infarction, and inherited cardiomyopathies to atherosclerosis, hypertension, stroke, and drug cardiotoxicity.
Kinase activity in cardiomyocytes, but also in endothelial cells, fibroblasts, and immune cells, has been shown to play an active role in cardiovascular pathophysiology. A comprehensive understanding of kinases in cardiovascular health and disease requires studies on molecular, cellular, organismal, and populational levels, utilizing experimental models and clinical data.
Therefore, all the research and advances on kinases and pseudokinases in cardiac (patho)physiology are welcome in this Special Issue. Original articles, comprehensive and critical reviews, and even letters are of utmost interest, given the broad interest in this area.
Dr. Julius Bogomolovas
Guest Editor
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Keywords
- Protein kinase C superfamily
- Mechanosensing kinases
- Small GTPase activated kinases
- Cardiovascular inflammation and remodeling
- Cardiotoxicity of kinase inhibitors
- Pseudokinases
- Lipid kinases
- Kinases in heart development
- Kinase inhibitors as therapeutic agents
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