Signaling Pathways in Organ Fibrosis

Dear Colleagues,

Fibroblasts, traditionally recognized as sentinel cells important for the architecture of the extracellular matrix, are more and more appreciated for their role in inflammation, angiogenesis, and electrophysiology. Particularly, their function as an inflammatory supporter cell, provoking chronic inflammation upon aberrant activation is gaining more attention in several fields, ranging from cardiology to pulmonology, nephrology, cancer, and autoimmune diseases. Fibroblasts differ from the anatomical site, the disease status, and even within the same tissue, and may have distinct cellular origins. Fibrosis, as such, is a complex dynamic process involving several cellular interactions and several signaling pathways. Further understanding of particularly the reciprocal link between inflammation and fibrosis is vital for establishing novel treatment strategies for diseases with fibrosis and inflammation.

Please join us in presenting this Special Issue on the state-of-the-art research currently being performed on organ fibrosis in different disciplines to gather our knowledge in view of gaining further common insights in this complex process.

Prof. Dr. med. Carsten Tschöpe
Dr. Sophie Van Linthout
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.