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JCM
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Application of Echocardiography in Clinical Practice
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Application of Echocardiography in Clinical Practice

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 479

Special Issue Editor

Dr. Shemy Carasso

E-Mail Website
Guest Editor
1. Division of Cardiovascular Medicine, B Padeh Medical Center, Poriya, Israel
2. The Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
Interests: digital cardiac imaging; echocardiography; CT; MRI; myocardial mechanics; valve diseases; heart failure; cardiomyopathies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Echocardiography is changing rapidly. Such changes include new methodologies of quantitative functional assessment of all chambers and valves, three-dimensional imaging and modeling, the coupling of ventricular–vascular assessments), artificial intelligence (AI) application (automation of measurements, reporting, and 3D modeling), and the new field of interventional echocardiography enabling complex transcatheter interventions. Access to echocardiography by AI-enhanced portable platforms, intended for non-echocardiographers, is also a major development that may improve patient care in the community.

The scope of this Special Issue of the Journal of Clinical Medicine is to present these new methodologies in echocardiography and assess the changes and their influence on clinical care, in the whole range from the community clinic to the interventional cath laboratory. We invite authors to submit papers on these clinical advances in terms of both diagnosis and treatment.

Dr. Shemy Carasso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • echocardiography
  • three-dimensional imaging
  • mechanical imaging
  • strain
  • artificial intelligence
  • interventional echocardiography
  • POCUS
  • hand-held echocardiography
  • cancer therapy and cardiotoxicity

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Published Papers (1 paper)

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Research

17 pages, 536 KB  
Article
Comprehensive Echocardiographic Assessment in Moderate Aortic Stenosis with Preserved Ejection Fraction Using Two-Dimensional Speckle-Tracking Echocardiography: Association with Functional Capacity
by Olga Petrovic, Dimitrije Zrnic, Stasa Vidanovic, Ivana Nedeljkovic, Olga Nedeljkovic-Arsenovic, Ana Petkovic, Ruzica Maksimovic, Sanja Stankovic, Marina Ostojic, Ivana Paunovic, Ivana Jovanovic, Milorad Tesic, Ana Uscumlic, Jelena Vratonjic, Goran Stankovic and Danijela Trifunovic-Zamaklar
J. Clin. Med. 2025, 14(22), 8065; https://doi.org/10.3390/jcm14228065 - 14 Nov 2025
Viewed by 294
Abstract
Background/Objectives: Moderate aortic stenosis (AS) with preserved ejection fraction (EF) is common, yet risk stratification remains challenging. Cardiopulmonary exercise testing (CPET) and myocardial mechanics analysis may identify subclinical dysfunction and impaired functional capacity. To evaluate the relationship between functional capacity (by % [...] Read more.
Background/Objectives: Moderate aortic stenosis (AS) with preserved ejection fraction (EF) is common, yet risk stratification remains challenging. Cardiopulmonary exercise testing (CPET) and myocardial mechanics analysis may identify subclinical dysfunction and impaired functional capacity. To evaluate the relationship between functional capacity (by % predicted peak VO2), ventilatory efficiency (VE/VCO2 slope), and myocardial mechanics (speckle tracking echocardiography—STE), and myocardial work (MW) indices) in moderate AS with preserved EF. Methods: We prospectively enrolled 107 patients with moderate AS (AVA 1.0–1.5 cm2; mean gradient 20–40 mmHg; EF ≥ 50%). Functional capacity was classified as preserved (≥83% predicted VO2) or reduced (<83%). Ventilatory efficiency was defined as good (<30) or poor (≥30) VE/VCO2 slope. STE assessed left ventricular (LV), left atrial (LA), and right ventricular (RV) strain, as well as myocardial work indices. Results: Patients with reduced % predicted VO2 had higher LV end-systolic volume (p = 0.035), lower stroke volume index (p = 0.020), and smaller indexed aortic valve area (p = 0.025), with trends toward lower GLS and myocardial work. In contrast, patients with poor ventilatory efficiency (VE/VCO2 ≥ 30) showed significant impairments in global longitudinal strain (GLS, p = 0.002), LA reservoir strain (PALS, p = 0.019) and LA conduit strain (LA Scd, p < 0.001), RV free wall strain (RW FWS, p = 0.029), and myocardial work indices (lower GWI and GCW, higher GWW, reduced GWE; all p < 0.05). LA Scd emerged as the strongest predictor of poor ventilatory efficiency. (receiver operating characteristic (ROC) area under the curve (AUC) 0.723, 95% confidence interval (CI) 0.623–0.823, p < 0.001). Conclusions: In moderate AS with preserved EF, impaired ventilatory efficiency is more strongly associated with subclinical LV, LA, and RV dysfunction than reduced % predicted VO2, highlighting the key role of RV impairment. Integrating CPET and STE improves phenotyping, identifying high-risk patients who may benefit from closer surveillance or early intervention. These findings are exploratory and hypothesis-generating; longitudinal data are needed to confirm prognostic implications. Full article
(This article belongs to the Special Issue Application of Echocardiography in Clinical Practice)
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